Prefrontal cortex and rule abstraction: where and whether? Theoretical comment on Moore et al. (2009).


:The primate dorsolateral prefrontal cortex is implicated in diverse aspects of behavioral regulation, cognitive control, and memory. However, direct neuropsychological evidence supporting a requirement of this area in functions other than spatial working memory has been scarce. T. L. Moore, S. P. Schettler, R. J. Killiany, D. L. Rosene, and M. B. Moss have shown, for the first time, that lesions of dorsolateral prefrontal cortex in the rhesus monkey (including areas 9 and 46) substantially impair performance in a test of executive function modeled on the Wisconsin Card Sorting Task. The pattern of impairment is consistent with a role for dorsolateral prefrontal areas in rule abstraction but may relate to a role for this area in rule maintenance as well. Interestingly, monkeys with dorsolateral prefrontal lesions do not appear to perseverate in their use of particular rules in the task, different from the common impairment associated with frontal lobe damage in humans. These findings indicate that dorsolateral prefrontal cortex is necessary for some aspects of rule-guided behavior in the primate brain and help illuminate the involvement of different prefrontal areas in different aspects of executive function and rule-guided behavior.


Behav Neurosci


Behavioral neuroscience


Baxter MG




Has Abstract


2009-04-01 00:00:00














  • Specificity of the cardiac response to conspecific vocalization in chimpanzees.

    abstract::Heart rate measures were used to examine the functional response of young chimpanzees and orangutans to acoustic stimuli, including white noise and chimpanzee vocalizations (threat, stress, and alarm). The initial response of the animals to all stimuli was characterized by a prominent cardiac deceleration and an incre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Berntson GG,Boysen ST

    更新日期:1989-04-01 00:00:00

  • Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function.

    abstract::This series of experiments investigated the role of a prefrontal cortical-dorsal striatal circuit in attention, using a continuous performance task of sustained and spatially divided visual attention. A unilateral excitotoxic lesion of the medial prefrontal cortex and a contralateral lesion of the medial caudate-putam...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Christakou A,Robbins TW,Everitt BJ

    更新日期:2001-08-01 00:00:00

  • Repeated fluoxetine administration during adolescence stimulates aggressive behavior and alters serotonin and vasopressin neural development in hamsters.

    abstract::Fluoxetine is the only selective serotonin reuptake inhibitor registered for the treatment of major depressive disorder in pediatric populations, despite reports that it is disproportionately associated with an array of adverse side effects that include agitation, hostility, and overt acts of pathological aggression a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Ricci LA,Melloni RH Jr

    更新日期:2012-10-01 00:00:00

  • Nonlinear temporal integration of brain stimulation reward.

    abstract::A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, altho...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Hawkins RD

    更新日期:2011-12-01 00:00:00

  • Hippocampal theta-band activity and trace eyeblink conditioning in rabbits.

    abstract::The authors examined the relationship between hippocampal theta activity and trace eyeblink conditioning. Hippocampal electrophysiological local field potentials were recorded before, during, and after conditioning or explicitly unpaired training sessions in adult male New Zealand White rabbits. As expected, a high re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Nokia MS,Penttonen M,Korhonen T,Wikgren J

    更新日期:2009-06-01 00:00:00

  • Perirhinal cortex contributions to performance in the Morris water maze.

    abstract::Rats with bilateral, electrolytic lesions of perirhinal cortex (PRC), lateral entorhinal cortex (LEC), or combined lesions (PRLE) were impaired relative to controls (sham) during initial acquisition in the Morris water maze, although all groups were eventually able to learn to locate the platform. A further deficit in...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Liu P,Bilkey DK

    更新日期:1998-04-01 00:00:00

  • Reinforcing properties of ejaculation in the male rat: role of opioids and dopamine.

    abstract::Ejaculation-induced reward in the male rat was evaluated by the conditioned place-preference paradigm. It was supposed that ejaculation induces a reward state such that it can be conditioned to environmental stimuli. Males were allowed to ejaculate once and were then immediately transferred to a place-preference cage....

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Agmo A,Berenfeld R

    更新日期:1990-02-01 00:00:00

  • Neuroethological studies of reflex plasticity in intact Aplysia.

    abstract::Multi-unit recording of siphon nerve activity in intact Aplysia california with chronically implanted cuff electrodes provided a monitor of activity in a central pattern generator, the Interneuron II (Int II) network, which produces large siphon and gill contractions both spontaneously and after tactile stimulation of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Eberly LB,Pinsker HM

    更新日期:1984-08-01 00:00:00

  • Anteromedial temporal lobe damage blocks startle modulation by fear and disgust.

    abstract::The acoustic startle reflex (ASR) is potentiated during negative emotion, but attenuated during positive emotional experience. The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilater...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Buchanan TW,Tranel D,Adolphs R

    更新日期:2004-04-01 00:00:00

  • Effects of passive-avoidance training on sleep-wake state-specific activity in the basolateral and central nuclei of the amygdala.

    abstract::This study examined the effects of intense emotional learning on the sleep-wake state-specific electroencephalographic (EEG) activities of the basolateral (BLA) and central (CeA) nuclei of the amygdala. Rats were trained on a passive-avoidance learning (PAL) protocol that was followed by 6 hr of undisturbed polygraphi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Mavanji V,Siwek DF,Patterson EH,Spoley EE,Datta S

    更新日期:2003-08-01 00:00:00

  • Hippocampal and amygdaloid involvement in nonspatial and spatial working memory in rats: effects of delay and interference.

    abstract::Parametric manipulations of the task demand were used to examine the role of the hippocampus and amygdala in nonspatial and spatial working memory in rats. Hippocampal lesions produced an immediate and long-lasting impairment of nonspatial working memory in an operant task. The memory deficits increased as the delay i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wan RQ,Pang K,Olton DS

    更新日期:1994-10-01 00:00:00

  • Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine.

    abstract::Large neocortical injuries can interfere with the initial performance of many previously learned behaviors. This dysfunction, however, may not be attributable to the loss of the memories of learned behaviors but to a failure to access memories that are spared. The results of this experiment support this hypothesis by ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: LeVere TE,Brugler T,Sandin M,Gray-Silva S

    更新日期:1989-06-01 00:00:00

  • Pineal transplantation to the brain of pinealectomized lizards: effects on circadian rhythms of locomotor activity.

    abstract::Pinealectomized lizards (Podarcis sicula) whose locomotor rhythms were recorded in constant temperature (29 degrees C) and darkness were subdivided into 2 groups of hosts: Each belonging to the 1st group (experimentals) received from a donor a pineal gland, and each belonging to the 2nd one (controls) received a piece...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Foà A,Bertolucci C,Marsanich A,Innocenti A

    更新日期:1997-10-01 00:00:00

  • Neuroticism and brain responses to anticipatory fear.

    abstract::Personality is known to influence cognitive and affective functioning as well as the risk of psychiatric disorders. Exploration of the neurobiological correlates of personality traits has the potential to enhance understanding of their significance in development of related psychopathological states. The authors exami...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kumari V,ffytche DH,Das M,Wilson GD,Goswami S,Sharma T

    更新日期:2007-08-01 00:00:00

  • Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.

    abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robinson-Drummer PA,Dokovna LB,Heroux NA,Stanton ME

    更新日期:2016-04-01 00:00:00

  • Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

    abstract::Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Francis HM,Stevenson RJ

    更新日期:2011-12-01 00:00:00

  • Reactivation of hippocampal ensemble activity patterns in the aging rat.

    abstract::In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Gerrard JL,Kudrimoti H,McNaughton BL,Barnes CA

    更新日期:2001-12-01 00:00:00

  • Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.

    abstract::The striatum is implicated in response selection and performance, the dorsal striatum in sensorimotor control and habit learning, and the ventral striatum in motivation and rewarded behaviors. Ventral striatal lesions produce performance changes on food-reinforced, progressive-ratio (PR) schedules, but the effects of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Eagle DM,Humby T,Dunnett SB,Robbins TW

    更新日期:1999-08-01 00:00:00

  • Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.

    abstract::This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intrac...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Takahashi LK,Kalin NH,Baker EW

    更新日期:1990-04-01 00:00:00

  • Influence of opioid peptides on learning and memory processes in the chick.

    abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Patterson TA,Schulteis G,Alvarado MC,Martinez JL Jr,Bennett EL,Rosenzweig MR,Hruby VJ

    更新日期:1989-04-01 00:00:00

  • Sensitivity to ethanol in inbred mice: genotypic correlations among several behavioral responses.

    abstract::The sensitivity of several inbred strains of mice was assessed for ethanol's effects on activity, body temperature, ataxia, balance, and the righting reflex. Genotypic correlations among the mean responses for the strains were estimated as indexes of pleiotropic influences of genes on drug responses. Three major group...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Crabbe JC

    更新日期:1983-04-01 00:00:00

  • Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.

    abstract::The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Rhodes JS,van Praag H,Jeffrey S,Girard I,Mitchell GS,Garland T Jr,Gage FH

    更新日期:2003-10-01 00:00:00

  • Olfactory associative learning in Caenorhabditis elegans is impaired in lrn-1 and lrn-2 mutants.

    abstract::The C. elegans mutants, lrn-1 and lrn-2, are impaired in associative learning using conditioned taste cues. Both mutants are defective in associative learning about appetitive and aversive events, indicating that lrn-1 and lrn-2 exert effects across motivational boundaries. In a new olfactory associative learning para...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Morrison GE,Wen JY,Runciman S,van der Kooy D

    更新日期:1999-04-01 00:00:00

  • Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring.

    abstract::Previous studies in Long-Evans rats demonstrated a significant relationship between variation in pup licking/grooming and arched-back nursing (LG-ABN) and offspring development. However, maternal care is dynamic and exhibits significant temporal variation. In the current study, we assessed temporal variation in LG and...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Jensen Peña C,Champagne FA

    更新日期:2013-02-01 00:00:00

  • Cross-modal savings in the contralateral eyelid conditioned response.

    abstract::The present experiment monitored bilateral eyelid responses during eyeblink conditioning in rats trained with a unilateral unconditioned stimulus (US). Three groups of rats were used to determine if cross-modal savings occurs when the location of the US is switched from one eye to the other. Rats in each group first r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Campolattaro MM,Buss EW,Freeman JH

    更新日期:2015-12-01 00:00:00

  • Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus).

    abstract::The authors measured the effects of centrally infused peptides on social approach behaviors in goldfish (Carassius auratus), a social teleost. Vasotocin (VT) inhibited approach responses toward the visual stimuli of conspecifics in the absence of aggressive or sexual olfactory contextual cues in males, and a V1 recept...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Thompson RR,Walton JC

    更新日期:2004-06-01 00:00:00

  • Developmental exposure to methimazole increases anxiety behavior in zebrafish.

    abstract::The role of thyroid hormones in vertebrate development has been well documented for several decades. As hypothyroidism during critical periods of development can cause defects to the development of every major organ system, including brain, eye, and general morphology, we hypothesized that hypothyroidism would affect ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Reider M,Connaughton VP

    更新日期:2015-10-01 00:00:00

  • The ontogeny of human learning in delay, long-delay, and trace eyeblink conditioning.

    abstract::The ontogeny of associative learning in delay (750-ms conditional stimulus [CS], 650-ms interstimulus interval [ISI]), long-delay (1,350-ms CS, 1,250-ms ISI), and trace (750-ms CS, 500-ms trace interval, 1,250-ms ISI) eyeblink conditioning was examined in 5-month-old human infants and adults. Infants and adults showed...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章


    authors: Herbert JS,Eckerman CO,Stanton ME

    更新日期:2003-12-01 00:00:00

  • Modulation of memory consolidation for olfactory learning by reversible inactivation of the basolateral amygdala.

    abstract::The role of the basolateral amygdala (BLA) in the consolidation of an association between an olfactory stimulus and footshock was investigated with a reversible lesion technique of post-training intra-BLA infusions of tetrodotoxin. Rats receiving tetrodotoxin infusions following paired odor-shock presentations spent m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kilpatrick L,Cahill L

    更新日期:2003-02-01 00:00:00

  • Perinatal stress effects on later anxiety and hormone secretion in male mandarin voles.

    abstract::The estradiol (E2), estrogen receptor-α (ERα), testosterone (T), and androgen receptor (AR) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. Here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: He FQ,Fang G,Wang B,Guo XJ,Guo CL

    更新日期:2015-12-01 00:00:00