Abstract:
:Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The present study identified the possible chromosomal loci regulating fear conditioning in BXD recombinant inbred strains using quantitative trait loci (QTL) analysis. Estimates of heritability for all 3 measures of conditioning were about .28. Correlational analyses between genetic markers and strain means identified multiple putative QTLs. The strongest associations were on Chromosomes 1 and 17 for freezing to the context, Chromosome 12 for freezing to an altered context, and Chromosome 1 for freezing to the auditory stimulus. Overlapping QTLs may indicate some common genes that underlie aspects of this learning task.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Owen EH,Christensen SC,Paylor R,Wehner JMdoi
10.1037//0735-7044.111.2.292subject
Has Abstractpub_date
1997-04-01 00:00:00pages
292-300issue
2eissn
0735-7044issn
1939-0084journal_volume
111pub_type
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