Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains.

Abstract:

:Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The present study identified the possible chromosomal loci regulating fear conditioning in BXD recombinant inbred strains using quantitative trait loci (QTL) analysis. Estimates of heritability for all 3 measures of conditioning were about .28. Correlational analyses between genetic markers and strain means identified multiple putative QTLs. The strongest associations were on Chromosomes 1 and 17 for freezing to the context, Chromosome 12 for freezing to an altered context, and Chromosome 1 for freezing to the auditory stimulus. Overlapping QTLs may indicate some common genes that underlie aspects of this learning task.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Owen EH,Christensen SC,Paylor R,Wehner JM

doi

10.1037//0735-7044.111.2.292

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

292-300

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

111

pub_type

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