Aging and ischemia in gerbils impair spatial memory performance.

Abstract:

:Gerbils aged 3 months and 24+ months were subjected to 5 min of global forebrain ischemia and tested in a radial arm maze (1 trial/day, 50 days). Compared with age-matched, sham-operated controls, ischemic animals were impaired on measures of both working and reference memory. Aged animals were impaired on working memory, but not on reference memory, compared with their younger counterparts. Hippocampal CA1 and CA2 regions were significantly and comparably damaged in the 2 ischemic groups but were unaffected by aging. The results suggest that aging and ischemia have functionally similar effects on working memory, but the 2 processes differentially impact reference memory.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Schwartz C,Wishart TB,Ijaz S,Shuaib A

doi

10.1037//0735-7044.112.4.937

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

937-41

issue

4

eissn

0735-7044

issn

1939-0084

journal_volume

112

pub_type

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