Abstract:
:Gerbils aged 3 months and 24+ months were subjected to 5 min of global forebrain ischemia and tested in a radial arm maze (1 trial/day, 50 days). Compared with age-matched, sham-operated controls, ischemic animals were impaired on measures of both working and reference memory. Aged animals were impaired on working memory, but not on reference memory, compared with their younger counterparts. Hippocampal CA1 and CA2 regions were significantly and comparably damaged in the 2 ischemic groups but were unaffected by aging. The results suggest that aging and ischemia have functionally similar effects on working memory, but the 2 processes differentially impact reference memory.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Schwartz C,Wishart TB,Ijaz S,Shuaib Adoi
10.1037//0735-7044.112.4.937subject
Has Abstractpub_date
1998-08-01 00:00:00pages
937-41issue
4eissn
0735-7044issn
1939-0084journal_volume
112pub_type
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