Abstract:
:Previous studies on drug abuse have shown that response to drug-associated cues exist during prolonged abstinence. In succession to previous investigations in our laboratory on morphine dependence and our research on acquisition and expression phases of morphine-conditioned place preference (CPP), in this study we attempt to determine the effects of intraaccumbal administration of SCH-23390, as a D1-like receptor antagonist, and sulpiride, as a D2-like receptor antagonist, in the maintenance of morphine-induced CPP in rats. Seventy-nine adult male Wistar rats weighing 200-280 g were bilaterally implanted with cannulas into the nucleus accumbens. During the 3-day conditioning phase, the animals received daily subcutaneous administration of morphine (5 mg/kg). CPP score and locomotor activity of animals were recorded by Ethovision software. Different doses (0.25, 1, 4 μg per 0.5 μL vehicle) of D1- and D2-like antagonists were bilateral injected daily after the expression phase and during the extinction phase. Our findings revealed that intraaccumbal administration of D1-like and D2-like antagonists after the CPP test shortened the extinction phase in the rats. The results suggested that the existence of the dopamine receptors in the nucleus accumbens was important for the maintenance of morphine-rewarding properties during the extinction phase. Therefore, dopamine receptors may be considered as a promising therapeutic agent in preventing the maintenance of morphine-rewarding effects in dependent individuals. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Namvar P,Zarrabian S,Nazari-Serenjeh F,Sadeghzadeh F,Haghparast Adoi
10.1037/bne0000336subject
Has Abstractpub_date
2019-12-01 00:00:00pages
556-562issue
6eissn
0735-7044issn
1939-0084pii
2019-48252-001journal_volume
133pub_type
杂志文章abstract::In male rats with food and water freely available, the specific dopamine D2 antagonist YM-09151-2 had little effect on total food or water intake across a 24-hr period. However, it produced a substantial dose-related decrease in feeding rate during meals and an enhancement of both meal size and duration. The equivalen...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.2.272
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abstract::The acoustic startle response (ASR) of male rats was measured during several sessions over a 24-hr period in both a light-dark cycle and a constant-dark condition. Each session consisted of 10 trials each at 80, 90, 100, 110, and 120 dB white noise. The results indicate robust daily and circadian modulation of ASR amp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.5.846
更新日期:1992-10-01 00:00:00
abstract::Animals with sham operations, hippocampal formation, or small and large parietal cortex lesions were trained in a task that required memory for short or long lists of items (spatial locations). More specifically, on any one trial, a rat is presented with 2, 4, 6, 8, or 10 items (spatial locations) on a 12-arm radial m...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.1.84
更新日期:1989-02-01 00:00:00
abstract::Biological markers for acquisition and extinction of fear conditioning were studied in 40 individuals selected for displaying either good or poor acquisition of fear conditioning. as estimated by the skin conductance response. Participants with a short serotonin transporter (5-HTT) promoter allele or low monoamine oxi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Spatial judgment is impaired in Parkinson's disease (PD), with previous research suggesting that disruptions in attention and executive function are likely contributors. If judgment of center places demands on frontal systems, performance on tests of attention/executive function may correlate with extent of bias in PD...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
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abstract::The estradiol (E2), estrogen receptor-α (ERα), testosterone (T), and androgen receptor (AR) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. Here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short...
journal_title:Behavioral neuroscience
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abstract::Rhesus monkeys were trained on 2 versions of delayed nonmatching-to-sample, one with multiple pairs of objects and the other with a single pair, to evaluate their ability to remember objects. They then received either bilateral aspiration lesions of the anterior rhinal cortex or bilateral excitotoxic lesions of the am...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::In contrast to humans, sodium-replete rats prefer dilute saline to water and do not prefer salted food to plain food. Sodium depletion is known to enhance the intake of and preference for salt provided in water. Here, we examined whether the context of the delivery vehicle for salt could influence salt intake and pref...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.4.565
更新日期:1988-08-01 00:00:00
abstract::The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000332
更新日期:2019-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.1.256
更新日期:2005-02-01 00:00:00
abstract::The purpose of this study was to characterize the ontogeny of the acoustic startle response (ASR) and response sensitization to background noise in preweanling rats. Animals were tested daily from 11 to 21 days of age using one of four sets of background white noise levels [45-80 dB(A)]. With constant low-level (45 dB...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.5.706
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abstract::Preadolescent mice have been shown to be differentially susceptible to the effects of both acute and chronic nicotine exposure on contextual fear learning relative to adults. For this study, we tested the effects of chronic nicotine exposure in preadolescence on adulthood extinction and spontaneous recovery of fear me...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000247
更新日期:2018-08-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.6.1276
更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.114.4.713
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0018320
更新日期:2010-02-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.98.4.609
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.117.4.751
更新日期:2003-08-01 00:00:00
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journal_title:Behavioral neuroscience
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doi:10.1037//0735-7044.116.5.912
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更新日期:2019-08-01 00:00:00
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journal_title:Behavioral neuroscience
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journal_title:Behavioral neuroscience
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doi:
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doi:10.1037/0735-7044.118.4.845
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journal_title:Behavioral neuroscience
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journal_title:Behavioral neuroscience
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