Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.


:Previous studies on drug abuse have shown that response to drug-associated cues exist during prolonged abstinence. In succession to previous investigations in our laboratory on morphine dependence and our research on acquisition and expression phases of morphine-conditioned place preference (CPP), in this study we attempt to determine the effects of intraaccumbal administration of SCH-23390, as a D1-like receptor antagonist, and sulpiride, as a D2-like receptor antagonist, in the maintenance of morphine-induced CPP in rats. Seventy-nine adult male Wistar rats weighing 200-280 g were bilaterally implanted with cannulas into the nucleus accumbens. During the 3-day conditioning phase, the animals received daily subcutaneous administration of morphine (5 mg/kg). CPP score and locomotor activity of animals were recorded by Ethovision software. Different doses (0.25, 1, 4 μg per 0.5 μL vehicle) of D1- and D2-like antagonists were bilateral injected daily after the expression phase and during the extinction phase. Our findings revealed that intraaccumbal administration of D1-like and D2-like antagonists after the CPP test shortened the extinction phase in the rats. The results suggested that the existence of the dopamine receptors in the nucleus accumbens was important for the maintenance of morphine-rewarding properties during the extinction phase. Therefore, dopamine receptors may be considered as a promising therapeutic agent in preventing the maintenance of morphine-rewarding effects in dependent individuals. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Behav Neurosci


Behavioral neuroscience


Namvar P,Zarrabian S,Nazari-Serenjeh F,Sadeghzadeh F,Haghparast A




Has Abstract


2019-12-01 00:00:00














  • Local dopamine production in the dorsal striatum restores goal-directed behavior in dopamine-deficient mice.

    abstract::To determine whether dopamine signaling in the dorsal striatum is sufficient for performance of goal-directed behaviors, local dopamine production was restored in the dorsal striatum of dopamine-deficient (DD) mice through viral-mediated gene therapy. Virally rescued DD (vrDD) mice were tested for learning of an appet...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robinson S,Sotak BN,During MJ,Palmiter RD

    更新日期:2006-02-01 00:00:00

  • Working memory across nostrils.

    abstract::Whether olfactory working memory involves verbal representations or neural images of odor per se remains unclear. This study investigated whether verbal representation influences performance in an olfactory delayed-match-to-sample task and used monorhinal presentation to generate hypotheses as to the underlying anatom...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Yeshurun Y,Dudai Y,Sobel N

    更新日期:2008-10-01 00:00:00

  • Persistent effects of a serotonin depletor (p-chlorophenylalanine) in regenerated planaria (Dugesia dorotocephala).

    abstract::p-Chlorophenylalanine (pCPA) caused an increase in looping and locomotion speed in planaria (Dugesia dorotocephala). These effects dissipated quickly after treatment, except in animals that regenerated from worms surgically sectioned after treatment. Planaria that regenerated from head sections showed more looping 6 a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kimmel HD,Carlyon WD

    更新日期:1990-02-01 00:00:00

  • Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition.

    abstract::Rats with perirhinal cortex lesions were sequentially trained in a rectangular water tank on a series of 3 visual discriminations, each between mirror-imaged stimuli. When these same discriminations were tested concurrently, the rats were forced to use a configural strategy to solve the problems effectively. There was...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Aggleton JP,Albasser MM,Aggleton DJ,Poirier GL,Pearce JM

    更新日期:2010-02-01 00:00:00

  • Characteristics of spatiotemporal integration in the priming and rewarding effects of medial forebrain bundle stimulation.

    abstract::Only the function relating the required pulse frequency to the interburst interval discriminates between the priming effect and the rewarding effect: Separating two short bursts of pulses has no effect on their combined rewarding effect, but it enhances their priming effect. There are significant nonscalar differences...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sax L,Gallistel CR

    更新日期:1991-12-01 00:00:00

  • Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus).

    abstract::The authors measured the effects of centrally infused peptides on social approach behaviors in goldfish (Carassius auratus), a social teleost. Vasotocin (VT) inhibited approach responses toward the visual stimuli of conspecifics in the absence of aggressive or sexual olfactory contextual cues in males, and a V1 recept...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Thompson RR,Walton JC

    更新日期:2004-06-01 00:00:00

  • Visual asymmetries in Japanese quail (Coturnix japonica) retain a lifelong potential for plasticity.

    abstract::Adult Japanese quail display left-eye/right-hemisphere dominance in visually guided sexual tracking. In 2 experiments, the authors set out to answer if this functional cerebral asymmetry is modifiable by posthatch monocular deprivation. In Experiment 1, the left or the right eye of 2-day old quail were closed for 70 d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Gülbetekin E,Güntürkün O,Dural S,Cetinkaya H

    更新日期:2009-08-01 00:00:00

  • The impact of napping on memory for future-relevant stimuli: Prioritization among multiple salience cues.

    abstract::Prior research has demonstrated that sleep enhances memory for future-relevant information, including memory for information that is salient due to emotion, reward, or knowledge of a later memory test. Although sleep has been shown to prioritize information with any of these characteristics, the present study investig...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Bennion KA,Payne JD,Kensinger EA

    更新日期:2016-06-01 00:00:00

  • Dopamine modulates novelty seeking behavior during decision making.

    abstract::Novelty seeking refers to the tendency of humans and animals to explore novel and unfamiliar stimuli and environments. The idea that dopamine modulates novelty seeking is supported by evidence that novel stimuli excite dopamine neurons and activate brain regions receiving dopaminergic input. In addition, dopamine is s...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Costa VD,Tran VL,Turchi J,Averbeck BB

    更新日期:2014-10-01 00:00:00

  • Delayed spontaneous alternation in intact and cerebellectomized control and lurcher mutant mice: differential role of cerebellar cortex and deep cerebellar nuclei.

    abstract::Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Caston J,Vasseur F,Delhaye-Bouchaud N,Mariani J

    更新日期:1997-02-01 00:00:00

  • Deficits for representational memory induced by septal and cortical lesions (singly and combined) in rats.

    abstract::A differentiation was made between dispositional memory and representational memory. A delayed-nonmatching-to-sample task in a T-maze operationalized this distinction. Experimental brain lesions in posterior septum and in prelimbic cortex resulted in amnesia for representational memories. The amnesia ameliorated as a ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Thomas GJ,Spafford PS

    更新日期:1984-06-01 00:00:00

  • Prefrontal cortex and rule abstraction: where and whether? Theoretical comment on Moore et al. (2009).

    abstract::The primate dorsolateral prefrontal cortex is implicated in diverse aspects of behavioral regulation, cognitive control, and memory. However, direct neuropsychological evidence supporting a requirement of this area in functions other than spatial working memory has been scarce. T. L. Moore, S. P. Schettler, R. J. Kill...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Baxter MG

    更新日期:2009-04-01 00:00:00

  • Novel objects in a holeboard probe the role of the locus coeruleus in curiosity: support for two modes of attention in the rat.

    abstract::Idazoxan, an alpha 2 adrenoceptor antagonist (2 mg/kg), enhanced novel object investigation in a holeboard in rats as previously reported (V. Devauges & S. J. Sara, 1990). Two weeks of 10 min/day in 37 degrees C water increased dopamine-beta-hydroxylase staining density in the locus coeruleus but did not enhance novel...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Mansour AA,Babstock DM,Penney JH,Martin GM,McLean JH,Harley CW

    更新日期:2003-06-01 00:00:00

  • Operant conditioning of hippocampal theta: dissociating reward from performance deficits.

    abstract::Dopaminergic blocking agents have been known to suppress intracranial self-stimulation, but whether the suppression results from a reduction in the rewarding value of stimulation or from motor deficits has remained controversial. We have resolved this controversy by developing an operant technique minimally dependent ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Fantie BD,Nakajima S

    更新日期:1987-10-01 00:00:00

  • Age differences in prenatal testosterone's protective effects on disordered eating symptoms: developmental windows of expression?

    abstract::Prenatal testosterone exposure may be protective against disordered eating. However, prior studies have produced mixed results. Developmental differences in prenatal testosterone's protective effects on disordered eating may explain these discrepancies. Indeed, studies have differed in the age of participants assessed...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Culbert KM,Breedlove SM,Sisk CL,Keel PK,Neale MC,Boker SM,Burt SA,Klump KL

    更新日期:2015-02-01 00:00:00

  • Central administration of cocaine produces age-dependent effects on behavior in the fetal rat.

    abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Simonik DK,Robinson SR,Smotherman WP

    更新日期:1994-12-01 00:00:00

  • Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans.

    abstract::The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Epstein LH,Temple JL,Neaderhiser BJ,Salis RJ,Erbe RW,Leddy JJ

    更新日期:2007-10-01 00:00:00

  • Differential behavioral response to dopamine D2 agonists by sexually naive, sexually active, and sexually inactive male rats.

    abstract::This study was performed with male rats categorized as sexually naive (SN), sexually active (SA), or sexually inactive (SI). In a first experiment the effects of dopamine (DA) D2 agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA and SI rats were assessed. In a second experiment the DA D2 ago...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Giuliani D,Ferrari F

    更新日期:1996-08-01 00:00:00

  • Associative retuning in the thalamic source of input to the amygdala and auditory cortex: receptive field plasticity in the medial division of the medial geniculate body.

    abstract::The medial division of the medial geniculate body (MGm) projects to the lateral amygdala and the upper layer of auditory cortex and develops physiological plasticity rapidly during classical conditioning. The effects of learning on frequency receptive fields (RFs) in the MGm of the guinea pig have been determined. Cla...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Edeline JM,Weinberger NM

    更新日期:1992-02-01 00:00:00

  • Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats.

    abstract::A unilateral microinjection of morphine into the amygdala impaired fear conditioning to both a conditioned stimulus (CS) paired with shock and the context where shock occurred, whereas a microinjection of morphine into the nucleus accumbens (NA) spared fear conditioning to the CS but impaired, in a dose-dependent and ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Westbrook RF,Good AJ,Kiernan MJ

    更新日期:1997-10-01 00:00:00

  • One-trial odor-reward association: a form of event memory not dependent on hippocampal function.

    abstract::To examine whether the hippocampus is required for memory for unique experiences independent of their spatial or temporal context, the authors devised a novel task that requires rats to remember odor-reward associations formed within a single training trial. Unlike previous tests of 1-trial memory, in this task new as...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wood ER,Agster KM,Eichenbaum H

    更新日期:2004-06-01 00:00:00

  • Sexual reinforcement is blocked by infusion of naloxone into the medial preoptic area.

    abstract::The present experiment was designed to determine whether infusions of naloxone into specific brain sites can block sexual reinforcement as evaluated with the conditioned place preference procedure. Methylnaloxonium (5 micrograms/cannula) was infused bilaterally either into the medial preoptic area (MPOA) or into the n...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Agmo A,Gómez M

    更新日期:1993-10-01 00:00:00

  • Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats.

    abstract::Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Mongeau R,De Oca BM,Fanselow MS,Marsden CA

    更新日期:1998-10-01 00:00:00

  • Trigeminal lesions and maternal behavior in Norway rats: I. Effects of cutaneous rostral snout denervation on maintenance of nurturance and maternal aggression.

    abstract::Cutaneous desensitization of the upper, rostral snout by bilateral section of the infraorbital nerves in lactating Norway rat dams markedly, but transiently, disrupted retrieval and licking of pups, nursing behavior, and fighting with a strange male intruder. Removal of the mystacial vibrissae, which provide major inp...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Stern JM,Kolunie JM

    更新日期:1991-12-01 00:00:00

  • Prenatal binge ethanol exposure on gestation days 19-20, but not on days 17-18, increases postnatal ethanol acceptance in rats.

    abstract::Previous research shows that prenatal binge ethanol exposure during gestation days (GD) 17 to 20 of the rat, increases postnatal ethanol intake and enhances ethanol's palatability, both effects being mediated by the opioid system. The amniotic fluid of the last period of gestation (GD 20) of the rat has been found to ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Díaz-Cenzano E,Chotro MG

    更新日期:2010-06-01 00:00:00

  • Hippocampal cells have behavioral correlates during the performance of an auditory working memory task in the rat.

    abstract::Single unit activity was recorded from the rat hippocampal CA1 and CA3 subfields, dentate gyrus (DG), entorhinal cortex (EC), subicular complex (SB), motor cortex (MC), prefrontal cortex (PFC), and dorsomedial thalamus (DMT) during performance of a continuous non-matching-to-sample task. The rats made go and no-go res...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sakurai Y

    更新日期:1990-04-01 00:00:00

  • Cross-modal savings in the contralateral eyelid conditioned response.

    abstract::The present experiment monitored bilateral eyelid responses during eyeblink conditioning in rats trained with a unilateral unconditioned stimulus (US). Three groups of rats were used to determine if cross-modal savings occurs when the location of the US is switched from one eye to the other. Rats in each group first r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Campolattaro MM,Buss EW,Freeman JH

    更新日期:2015-12-01 00:00:00

  • The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of morphine.

    abstract::Bilateral ibotenic acid lesions of the lateral, but not the medial, parabrachial nucleus (PBN) blocked conditioned taste aversion (CTA) induced by morphine but not conditioned place preference induced by morphine. The same lateral PBN lesions also blocked conditioned place aversion produced by low intraperitoneal dose...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Bechara A,Martin GM,Pridgar A,van der Kooy D

    更新日期:1993-02-01 00:00:00

  • Preferential use of the landmark navigational system by head direction cells in rats.

    abstract::Previous studies have identified a population of cells recorded in the postsubiculum and the anterior thalamic nucleus (ATN) that discharge as a function of an animal's head direction (HD) in the horizontal plane. The present experiments monitored HD cell activity when rats were confronted with a situation in which di...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Goodridge JP,Taube JS

    更新日期:1995-02-01 00:00:00

  • Angiotensin and salt appetite: physiological amounts of angiotensin given peripherally increase salt appetite in the rat.

    abstract::Two experiments were conducted in which adrenalectomized male Sprague-Dawley rats were maintained ad lib on distilled water, 3% saline, and sodium-free food. In Experiment 1, 45 rats were given 100, 200, 400, 800, and 1,000 micrograms/kg/day desoxycorticosterone acetate (DOCA) im for 5 days to determine the dose of DO...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dalhouse AD,Langford HG,Walsh D,Barnes T

    更新日期:1986-08-01 00:00:00