Abstract：
:The sensitivity of several inbred strains of mice was assessed for ethanol's effects on activity, body temperature, ataxia, balance, and the righting reflex. Genotypic correlations among the mean responses for the strains were estimated as indexes of pleiotropic influences of genes on drug responses. Three major groups of genetic influence were detected: (a) hypothermic sensitivity to ethanol, (b) activity change (increase after ethanol), and (c) high basal activity. In the first group of variables, strains that had large reductions in body temperature after being given ethanol had high baseline temperatures, pronounced ataxic response to ethanol, and a long-lasting loss of righting reflex. Home cage baseline activity was negatively correlated with body temperature variables. The second group of variables was composed largely of ethanol-induced increases and decreases in activity, which were negatively intercorrelated. Strains with larger increases in activity showed more rapid loss of balance after ethanol. The third group of variables indicated that high levels of basal activity in an open field and in the home cage were determined by the action of common genes. Strains with higher basal activity levels had reduced sensitivity to ambulatory ataxia following ethanol. Thus, there were substantial pleiotropic effects of common genes on several behavioral responses to ethanol in inbred mice. Conversely, the three major groups were not systematically correlated with one another to a major extent. This suggests the influence of three reasonably distinct sets of genes on these responses to ethanol.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Crabbe JCdoi
10.1037//0735-7044.97.2.280subject
Has Abstractpub_date
1983-04-01 00:00:00pages
280-9issue
2eissn
0735-7044issn
1939-0084journal_volume
97pub_type
杂志文章abstract：:Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.103.2.429
更新日期：1989-04-01 00:00:00
abstract：:The authors have previously demonstrated that Purkinje cell-degeneration (pcd) mutant mice are impaired in eyeblink conditioning (L. Chen et al., 1996a). The present study addresses the following 3 questions: (a) whether pcd mice perceive the conditioned and unconditioned stimuli as well as the wild-type mice, (b) whe...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.113.1.204
更新日期：1999-02-01 00:00:00
abstract：:The aim of this study was to investigate the effects of postnatal choline supplementation on neurochemical and behavioral parameters in preweanling BALB/cByJ mice. Mouse pups were injected daily subcutaneously with choline chloride (0.85 mM/g body weight) from Postnatal Day (PND) 1 to PND 16. Pups performed a passive ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:In previous studies the cerebellar interpositus (IP) nucleus, but not the hippocampus, was shown to be necessary both for initial learning and retention and for long-term retention of the standard delay eyeblink conditioned response (CR). However, in the trace eyeblink CR procedure, the hippocampus is also necessary f...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0014263
更新日期：2009-02-01 00:00:00
abstract：:Many studies have pointed to vulnerability to stress and stress-related pathologies at different timepoints during an individual's life span. These sensitive windows are usually during periods of neural development, such as embryogenesis, infancy, and adolescence. It is critical to understand how neural circuitry may ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0033602
更新日期：2013-10-01 00:00:00
abstract：:Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/0735-7044.122.2.416
更新日期：2008-04-01 00:00:00
abstract：:Pinealectomized lizards (Podarcis sicula) whose locomotor rhythms were recorded in constant temperature (29 degrees C) and darkness were subdivided into 2 groups of hosts: Each belonging to the 1st group (experimentals) received from a donor a pineal gland, and each belonging to the 2nd one (controls) received a piece...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.111.5.1123
更新日期：1997-10-01 00:00:00
abstract：:Neonatal handling induces long-lasting effects on behaviors and stress responses. The objective of the present study was to analyze the effects of neonatal handling (from the 1st to the 10th day after delivery) on the number of cells and volume of locus coeruleus (LC) nucleus in male and female rats at 4 different age...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/0735-7044.117.5.894
更新日期：2003-10-01 00:00:00
abstract：:Prader-Willi syndrome (PWS) is caused by lack of paternally derived gene expression from the imprinted gene cluster on human chromosome 15q11-q13. PWS is characterized by severe hypotonia, a failure to thrive in infancy and, on emerging from infancy, evidence of learning disabilities and overeating behavior due to an ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0028155
更新日期：2012-06-01 00:00:00
abstract：:Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0016328
更新日期：2009-08-01 00:00:00
abstract：:This study was conducted to investigate the effects of instruction types on hemispheric activation and accurate selection of spatial stimuli that had been previously presented at a subliminal level. Right-handed females randomly received either an "analytic" or a "holistic" instruction. Both groups first saw a series ...
journal_title：Behavioral neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1037//0735-7044.100.3.343
更新日期：1986-06-01 00:00:00
abstract：:Neuromuscular impairment by ethanol likely involves complex effects on balance, gait, muscle strength, and other features of motor coordination. The present experiments showed that relative sensitivity to ethanol-induced motor impairment in serotonin 1B (5-HT(1B)) null mutant and control mice was task dependent. We fo...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.103.3.504
更新日期：1989-06-01 00:00:00
abstract：:Theories of habituation have included an increase in postsynaptic inhibition as one possible mechanism underlying response decrement following repetitive stimulus presentation. In this study, the glycine antagonist strychnine (1.0 mg/kg, ip, 10 min pretreatment) was used to investigate the involvement of glycinergic n...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.98.6.955
更新日期：1984-12-01 00:00:00
abstract：:Rhesus monkeys were trained on 2 versions of delayed nonmatching-to-sample, one with multiple pairs of objects and the other with a single pair, to evaluate their ability to remember objects. They then received either bilateral aspiration lesions of the anterior rhinal cortex or bilateral excitotoxic lesions of the am...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Two experiments examined the effects of infusing an N-methyl-D-aspartate (NMDA) receptor antagonist, d-2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impair...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.109.4.663
更新日期：1995-08-01 00:00:00
abstract：:It is widely believed that male mammals have better spatial ability than females. A large number of evolutionary hypotheses have been proposed to explain these differences, but few species have been tested. The authors critically review the proposed evolutionary explanations for sex differences in spatial cognition an...
journal_title：Behavioral neuroscience
pub_type： 杂志文章,评审
doi：10.1037/0735-7044.117.3.403
更新日期：2003-06-01 00:00:00
abstract：:Rats with unilateral dopamine (DA) depletion (hemiParkinson analogue rats) are impaired in using the contralateral (bad) limbs for skilled movements and for postural adjustments and compensate by using their good limbs in novel ways. The present study consisted of a reaching task in which compensatory adjustments usin...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.110.1.117
更新日期：1996-02-01 00:00:00
abstract：:Previous studies on drug abuse have shown that response to drug-associated cues exist during prolonged abstinence. In succession to previous investigations in our laboratory on morphine dependence and our research on acquisition and expression phases of morphine-conditioned place preference (CPP), in this study we att...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/bne0000336
更新日期：2019-12-01 00:00:00
abstract：:This study reexamined Grigson's reward comparison hypothesis (1997), which claimed to have resolved the paradox of addictive, rewarding drugs manifesting an aversive effect in the conditioned taste aversion (CTA) paradigm. Here, the authors compared the conditioned suppression effects of lithium chloride (LiCl) and am...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0013511
更新日期：2008-12-01 00:00:00
abstract：:The rat's willingness to ingest glucose after an initial intraoral intake test was probed by beginning a 2nd intraoral intake test at variable durations (1-120 min). In Experiment 1, after an initial meal of 12.5% glucose solution averaging 26.9 +/- 1.7 ml (SEM, n = 10), the size of the 2nd (probe) meal of the same st...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Amygdala central nucleus (CNA) lesions were used to test the hypothesis that stimulus-evoked heart rate changes can reflect the development of fear during acoustic startle testing. A 120-dB white noise startle stimulus produced freezing as well as phasic heart rate accelerations and decelerations, and an abrupt decrea...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.110.2.228
更新日期：1996-04-01 00:00:00
abstract：:Vasopressin-immunoreactive (AVP-ir) cells in the bed nucleus of the stria terminalis (BST) and medial amygdaloid nucleus (MA) and their AVP-ir projections to the lateral septum were studied in monogamous prairie voles (Microtus ochrogaster) and promiscuous meadow voles (M. pennsylvanicus). A sexually dimorphic AVP-ir ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.109.2.305
更新日期：1995-04-01 00:00:00
abstract：:Rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) and sham-operated rats were trained in either a simple discrimination paradigm assessing simple association learning or a negative patterning paradigm assessing configural association learning. In the simple discrimination task, rats were r...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.116.2.241
更新日期：2002-04-01 00:00:00
abstract：:Female rats exhibit a conditioned place preference (CPP) for a context paired with mating. The present experiment tested the hypothesis that the activation of the pelvic nerve mediates the reinforcing effects of mating for female rats. Rats underwent bilateral pelvic nerve or sham transection and then received paced m...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0015267
更新日期：2009-06-01 00:00:00
abstract：:Fear reactions of rats given bilateral lesions to the septum, hippocampus, or amygdala were compared with those of rats given sham lesions, in 2 animal models of anxiety: the shock-probe burying test and the elevated plus-maze test. Septal lesions produced anxiolytic effects in both tests (i.e., an increase in open-ar...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.111.3.653
更新日期：1997-06-01 00:00:00
abstract：:The experiments addressed the question of whether certain modalities of stimulation are more effective in eliciting immobility-related, atropine-sensitive neocortical low-voltage fast activity and hippocampal rhythmical slow activity from the rabbit. More pronounced activation and less pronounced habituation followed ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.98.2.333
更新日期：1984-04-01 00:00:00
abstract：:Habituation has traditionally been considered a nonassociative form of learning. However, recent research suggests that retention of this nonassociative form of learning may be aided by associations formed during training. An example of this is context conditioning, in which animals that are trained and tested in the ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Two experiments used an associative blocking design to study the role of dopamine receptors in the nucleus accumbens shell (AcbSh) and core (AcbC) in fear prediction error. Rats in the experimental groups were trained to a visual fear-conditioned stimulus (conditional stimulus [CS]) A in Stage I, whereas rats in the c...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/bne0000071
更新日期：2015-08-01 00:00:00
abstract：:Estrogens have been shown to rapidly promote male copulatory behaviors with a time-course that suggests rapid signaling events are involved. The present study tested the hypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER). Thus, either estradiol (E2), STX (a diphenylacrylam...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0032950
更新日期：2013-08-01 00:00:00
