Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis.

Abstract:

:Rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) and sham-operated rats were trained in either a simple discrimination paradigm assessing simple association learning or a negative patterning paradigm assessing configural association learning. In the simple discrimination task, rats were reinforced for responding to a light but were not reinforced for responding to a tone. In the negative patterning discrimination task, rats were reinforced for responding to either a light or a tone presented alone but were not reinforced for responding to both stimuli presented simultaneously. Simple discrimination learning was not affected, whereas acquisition of negative patterning was impaired by NBM lesions. Impaired configural association learning may reflect a loss in the ability of rats with NBM lesions to attend to multiple sensory stimuli or to cope with conflicting response strategies.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Butt AE,Noble MM,Rogers JL,Rea TE

doi

10.1037//0735-7044.116.2.241

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

241-55

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

116

pub_type

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