Abstract:
:Rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) and sham-operated rats were trained in either a simple discrimination paradigm assessing simple association learning or a negative patterning paradigm assessing configural association learning. In the simple discrimination task, rats were reinforced for responding to a light but were not reinforced for responding to a tone. In the negative patterning discrimination task, rats were reinforced for responding to either a light or a tone presented alone but were not reinforced for responding to both stimuli presented simultaneously. Simple discrimination learning was not affected, whereas acquisition of negative patterning was impaired by NBM lesions. Impaired configural association learning may reflect a loss in the ability of rats with NBM lesions to attend to multiple sensory stimuli or to cope with conflicting response strategies.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Butt AE,Noble MM,Rogers JL,Rea TEdoi
10.1037//0735-7044.116.2.241subject
Has Abstractpub_date
2002-04-01 00:00:00pages
241-55issue
2eissn
0735-7044issn
1939-0084journal_volume
116pub_type
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