Shock-induced hyperalgesia: II. Role of the dorsolateral periaqueductal gray.

Abstract:

:Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explored whether shock-induced hyperalgesia depends on neurons within rostral or caudal portions of the dorsolateral periaqueductal gray (dlPAG). Experiment 1 examined the impact of dlPAG lesions on the acquisition of conditioned fear. Sham-operated rats demonstrated enhanced acquisition after shock exposure; both rostral and caudal lesions eliminated this effect. Experiment 2 showed that tailshock lowered vocalization thresholds to heat in sham-operated but not lesioned subjects. These results suggest that the dlPAG plays a critical role in the production of shock-induced hyperalgesia.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

McLemore S,Crown ED,Meagher MW,Grau JW

doi

10.1037//0735-7044.113.3.539

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

539-49

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

113

pub_type

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