Shock-induced hyperalgesia: II. Role of the dorsolateral periaqueductal gray.


:Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explored whether shock-induced hyperalgesia depends on neurons within rostral or caudal portions of the dorsolateral periaqueductal gray (dlPAG). Experiment 1 examined the impact of dlPAG lesions on the acquisition of conditioned fear. Sham-operated rats demonstrated enhanced acquisition after shock exposure; both rostral and caudal lesions eliminated this effect. Experiment 2 showed that tailshock lowered vocalization thresholds to heat in sham-operated but not lesioned subjects. These results suggest that the dlPAG plays a critical role in the production of shock-induced hyperalgesia.


Behav Neurosci


Behavioral neuroscience


McLemore S,Crown ED,Meagher MW,Grau JW




Has Abstract


1999-06-01 00:00:00












  • Association of sleep parameters and memory in intact old rats and young rats with lesions in the nucleus basalis magnocellularis.

    abstract::Relations between sleep and memory were examined as a function of aging in rats. Sleep (24 hr), passive avoidance retention, and choline acetyltransferase (CAT) activity were assessed in 3 age-groups (6, 15, and 24 months old). Age-related alterations were evident in sleep, memory, and cortical and striatal CAT activi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Stone WS,Altman HJ,Berman RF,Caldwell DF,Kilbey MM

    更新日期:1989-08-01 00:00:00

  • Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function.

    abstract::This series of experiments investigated the role of a prefrontal cortical-dorsal striatal circuit in attention, using a continuous performance task of sustained and spatially divided visual attention. A unilateral excitotoxic lesion of the medial prefrontal cortex and a contralateral lesion of the medial caudate-putam...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Christakou A,Robbins TW,Everitt BJ

    更新日期:2001-08-01 00:00:00

  • Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster).

    abstract::Male prairie voles (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP V1a receptor antagonist in the lateral se...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Liu Y,Curtis JT,Wang Z

    更新日期:2001-08-01 00:00:00

  • Sex versus sweet: opposite effects of opioid drugs on the reward of sucrose and sexual pheromones.

    abstract::Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Agustín-Pavón C,Martínez-Ricós J,Martínez-García F,Lanuza E

    更新日期:2008-04-01 00:00:00

  • Effects of benzodiazepine receptor ligands on the ingestion of sucrose, intralipid, and maltodextrin: an investigation using a microstructural analysis of licking behavior in a brief contact test.

    abstract::Microstructural analysis of licking behavior in the rat was conducted (a) to describe in detail the characteristics of benzodiazepine-induced changes in ingestion and (b) to determine if the changes are consistent with an alteration in palatability. The effects of the benzodiazepine receptor (BZR) agonist midazolam (0...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Higgs S,Cooper SJ

    更新日期:1998-04-01 00:00:00

  • HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height.

    abstract::Rats with unilateral dopamine (DA) depletion (hemiParkinson analogue rats) are impaired in using the contralateral (bad) limbs for skilled movements and for postural adjustments and compensate by using their good limbs in novel ways. The present study consisted of a reaching task in which compensatory adjustments usin...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Miklyaeva EI,Whishaw IQ

    更新日期:1996-02-01 00:00:00

  • Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

    abstract::PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-behavioral deficits and whether these deficits occur before or after a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dodart JC,Meziane H,Mathis C,Bales KR,Paul SM,Ungerer A

    更新日期:1999-10-01 00:00:00

  • Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats.

    abstract::The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Steidl S,Li L,Yeomans JS

    更新日期:2001-06-01 00:00:00

  • Effect of social isolation on anxiety-related behaviors, cortisol, and monoamines in adult zebrafish.

    abstract::Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the authors examined behavior (social and ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Shams S,Seguin D,Facciol A,Chatterjee D,Gerlai R

    更新日期:2017-12-01 00:00:00

  • Preferential use of the landmark navigational system by head direction cells in rats.

    abstract::Previous studies have identified a population of cells recorded in the postsubiculum and the anterior thalamic nucleus (ATN) that discharge as a function of an animal's head direction (HD) in the horizontal plane. The present experiments monitored HD cell activity when rats were confronted with a situation in which di...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Goodridge JP,Taube JS

    更新日期:1995-02-01 00:00:00

  • Neural cell adhesion molecules, learning, and memory in the domestic chick.

    abstract::The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. The results reported here demonstrate that neural cell adhesion molecules (NCAMs) play a time-dependent role in this recognition memory. Dark-reared chicks were train...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Solomonia RO,McCabe BJ,Horn G

    更新日期:1998-06-01 00:00:00

  • Sensitization of ingestive responding in preweanling rats: time course and specificity.

    abstract::Two experiments measured the response-enhancing effects of oral stimulation in young rats with no feeding experience. In Experiment 1, pups were implanted with oral cannulas and deprived for 0, 6, or 24 hr. In nondeprived rats, sucrose exposure transiently sensitized oral responding to subsequent stimuli for several m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Myers KP,Arnold HM,Hall WG

    更新日期:1997-04-01 00:00:00

  • Cardiovascular mediation of clonidine-induced ultrasound production in infant rats.

    abstract::In infant rats, administration of the alpha2 adrenoceptor agonist clonidine simultaneously evokes ultrasound production and bradycardia. In this study the authors examined in 8-day-old rats whether these 2 responses to clonidine are causally related. In Experiment 1 pups were pretreated with saline or prenalterol (0.1...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Blumberg MS,Kreber LA,Sokoloff G,Kent KJ

    更新日期:2000-06-01 00:00:00

  • Receptor contributions to configural and elemental odor mixture perception.

    abstract::Odor mixture perception can be configural (the mixture is qualitatively different from the components) or elemental (the components are recognizable). Some have argued that configural properties are dependent on chemical similarity and possible overlap at the receptor level. The authors show that a binary mixture in w...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kay LM,Lowry CA,Jacobs HA

    更新日期:2003-10-01 00:00:00

  • Behavioral spectral sensitivities of different retinal areas in pigeons.

    abstract::The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Remy M,Emmerton J

    更新日期:1989-02-01 00:00:00

  • Role of instrumental learning in tolerance to cathinone hypophagia.

    abstract::The effects of dl-cathinone on milk intake and motor activity were investigated in bottle- and cannula-fed rats. Acute injections of cathinone produced dose-dependent increases in activity in both groups but only produced decreased intake in bottle-fed rats. With chronic injections, tolerance to the suppression of int...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wolgin DL,Munoz JR

    更新日期:2006-04-01 00:00:00

  • Emotion-modulated startle reflex during reappraisal: Probe timing and behavioral correlates.

    abstract::Down-regulation of negative emotions has been shown to reliably inhibit the emotion-modulated startle reflex, but it remains unclear whether the timing of the startle probe influences the quantification of emotion regulation with this measure. Moreover, it is not known whether the degree of startle inhibition correspo...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Zaehringer J,Schmahl C,Ende G,Paret C

    更新日期:2018-12-01 00:00:00

  • Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.

    abstract::This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intrac...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Takahashi LK,Kalin NH,Baker EW

    更新日期:1990-04-01 00:00:00

  • Effects of parturition and maternal experience on noradrenaline and acetylcholine release in the olfactory bulb of sheep.

    abstract::Acetylcholine (ACh) and noradrenaline (NA) release in the olfactory bulb (OB) of ewes was monitored using microdialysis. Both ACh and NA release increased at parturition in multiparous but not in primiparous ewes. However, vaginocervical stimulation performed 6 hr postpartum induced an increase of ACh and NA release i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lévy F,Guevara-Guzman R,Hinton MR,Kendrick KM,Keverne EB

    更新日期:1993-08-01 00:00:00

  • Hippocampal growth and maintenance depend on food-caching experience in juvenile mountain chickadees (Poecile gambeli).

    abstract::This experiment investigated the development of caching behavior and the hippocampus (HF) in postfledging mountain chickadees (Poecile gambeli). From Days 35 to 53, the number of seeds stored increased but the proportion recovered did not. Birds that stored and recovered during 3 or more trials had significantly enlar...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Clayton NS

    更新日期:2001-06-01 00:00:00

  • Adrenal responses to reinforcement and extinction: role of expectancy versus instrumental responding.

    abstract::Plasma corticosterone levels were evaluated during operant conditioning in order to determine the effect of reinforced and nonreinforced responding (extinction) on adrenal activation. The influence of instrumental responding was assessed by comparing trained rats with yoked subjects that received a matched reward sche...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Coe CL,Stanton ME,Levine S

    更新日期:1983-08-01 00:00:00

  • Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore.

    abstract::This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impa...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kleen JK,Sitomer MT,Killeen PR,Conrad CD

    更新日期:2006-08-01 00:00:00

  • The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference.

    abstract::There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Shen F,Wang N,Qi C,Li YJ,Cui CL

    更新日期:2014-08-01 00:00:00

  • Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach.

    abstract::Cost-benefit decision making is essential for organisms to adapt to their ever-changing environment. Most studies of cost-benefit decision making involve choice conditions in which effort and value are varied simultaneously. This prevents identification of the aspects of cost-benefit decision making that are affected ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Bailey MR,Chun E,Schipani E,Balsam PD,Simpson EH

    更新日期:2020-04-01 00:00:00

  • Chronic lithium chloride infusions: conditioned suppression of food intake and preference.

    abstract::A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acqu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Bernstein IL,Goehler LE

    更新日期:1983-04-01 00:00:00

  • Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia.

    abstract::Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: McGlinchey-Berroth R,Carrillo MC,Gabrieli JD,Brawn CM,Disterhoft JF

    更新日期:1997-10-01 00:00:00

  • Amygdalo-striatal interaction in the enhancement of stimulus salience in associative learning.

    abstract::Function of the central nucleus of the amygdala (CeA) is critical to 2 aspects of attention in associative learning: the conditioning of orienting responses (ORs) to cues paired with food, and the enhancement of cue salience by the surprising omission of expected events. Such salience enhancements have been found to d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Esber GR,Torres-Tristani K,Holland PC

    更新日期:2015-04-01 00:00:00

  • Consequences of serial cortical, hippocampal, and thalamic lesions and of different lengths of overtraining on the acquisition and retention of learning tasks.

    abstract::The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Markowitsch HJ,Kessler J,Streicher M

    更新日期:1985-04-01 00:00:00

  • Re-examination of amphetamine-induced conditioned suppression of tastant intake in rats: the task-dependent drug effects hypothesis.

    abstract::This study reexamined Grigson's reward comparison hypothesis (1997), which claimed to have resolved the paradox of addictive, rewarding drugs manifesting an aversive effect in the conditioned taste aversion (CTA) paradigm. Here, the authors compared the conditioned suppression effects of lithium chloride (LiCl) and am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Huang AC,Hsiao S

    更新日期:2008-12-01 00:00:00

  • Biophysical and behavioral correlates of memory storage, degradation, and reactivation.

    abstract::Neural correlates of associative memory and "forgetting" were observed 1, 6, and 14 days after acquisition of a conditioned response (CR) in the marine snail Hermissenda. Behavioral expression of a light-rotation association, as indexed by contraction of the animal's foot in response to light, dissipated throughout th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Matzel LD,Collin C,Alkon DL

    更新日期:1992-12-01 00:00:00