Abstract:
:Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explored whether shock-induced hyperalgesia depends on neurons within rostral or caudal portions of the dorsolateral periaqueductal gray (dlPAG). Experiment 1 examined the impact of dlPAG lesions on the acquisition of conditioned fear. Sham-operated rats demonstrated enhanced acquisition after shock exposure; both rostral and caudal lesions eliminated this effect. Experiment 2 showed that tailshock lowered vocalization thresholds to heat in sham-operated but not lesioned subjects. These results suggest that the dlPAG plays a critical role in the production of shock-induced hyperalgesia.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
McLemore S,Crown ED,Meagher MW,Grau JWdoi
10.1037//0735-7044.113.3.539subject
Has Abstractpub_date
1999-06-01 00:00:00pages
539-49issue
3eissn
0735-7044issn
1939-0084journal_volume
113pub_type
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