Response characteristics of neurons in the medial component of the medial geniculate nucleus during Pavlovian differential fear conditioning in rabbits.

Abstract:

:Recent evidence suggests that the amygdaloid central nucleus (ACE) may contribute significantly to Pavlovian fear-conditioned bradycardic responses during the presentation of conditioned emotional stimuli. Because the medial component of the medial geniculate nucleus (MGm) is a major source of input to the region of the ACE, the extracellular single-unit responses of MGm neurons were examined during Pavlovian differentially conditioned bradycardic responding in rabbits. Conditioning involved pairing one tone (CS+) with paraorbital shock and presenting another tone (CS-) in the absence of shock. Two general classes of MGm neurons were identified based on their conditioned-response characteristics. Both groups responded differentially to the CSs. One group responded with greater increases in activity and at a shorter latency to the CS+ compared with the CS-, whereas the other group responded with greater increases in activity and at a shorter latency to the CS- compared with the CS+. Recordings from MGm neurons in naive rabbits prior to conditioning provided evidence that the acoustic stimuli used subsequently as the CS+ and CS- did not evoke differential responses. These results suggest that the MGm along with the ACE may be forebrain components of a neural circuit involved in the acquisition and/or expression of Pavlovian fear-conditioned bradycardic responses.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Supple WF Jr,Kapp BS

doi

10.1037//0735-7044.103.6.1276

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

1276-86

issue

6

eissn

0735-7044

issn

1939-0084

journal_volume

103

pub_type

杂志文章
  • Amygdala central nucleus lesions attenuate acoustic startle stimulus-evoked heart rate changes in rats.

    abstract::Amygdala central nucleus (CNA) lesions were used to test the hypothesis that stimulus-evoked heart rate changes can reflect the development of fear during acoustic startle testing. A 120-dB white noise startle stimulus produced freezing as well as phasic heart rate accelerations and decelerations, and an abrupt decrea...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.2.228

    authors: Young BJ,Leaton RN

    更新日期:1996-04-01 00:00:00

  • Opioid action on response level to a danger stimulus in the crab (Chasmagnathus granulatus).

    abstract::When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the response to a dang...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.5.1139

    authors: Maldonado H,Romano A,Lozada M

    更新日期:1989-10-01 00:00:00

  • Consequences of serial cortical, hippocampal, and thalamic lesions and of different lengths of overtraining on the acquisition and retention of learning tasks.

    abstract::The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Markowitsch HJ,Kessler J,Streicher M

    更新日期:1985-04-01 00:00:00

  • Chronic citalopram treatment ameliorates depressive behavior associated with light at night.

    abstract::Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether thi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0029699

    authors: Bedrosian TA,Weil ZM,Nelson RJ

    更新日期:2012-10-01 00:00:00

  • Involvement of nitric oxide in sexual learning via action in the medial preoptic area: theoretical comment on Lagoda et al. (2004).

    abstract::Repeated exposure to female-related stimuli causes functional alterations in the neural circuitry mediating male rat sexual behavior. In a study published in the current issue of this journal, G. M. Lagoda, J. W. Muschamp, A. Vigdorchik, and E. M. Hull (2004) provide interesting new evidence as to the mechanisms respo...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/0735-7044.118.6.1473

    authors: Coolen LM

    更新日期:2004-12-01 00:00:00

  • Interactive contributions of intracellular calcium and protein phosphatases to massed-trials learning deficits in Hermissenda.

    abstract::Using Hermissenda as subjects, massed-trials training deficits were examined. Associative pairings of light and rotation induced a progressively greater conditioned foot contraction in response to light as the intertrial interval (ITI) was extended (up to 8 min). In contrast, a short ITI (30 s) produced no evidence of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.1.103

    authors: Muzzio IA,Ramirez RR,Talk AC,Matzel LD

    更新日期:1999-02-01 00:00:00

  • Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.

    abstract::Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037/0735-7044.117.3.517

    authors: Buchanan TW,Karafin MS,Adolphs R

    更新日期:2003-06-01 00:00:00

  • Preferential use of the landmark navigational system by head direction cells in rats.

    abstract::Previous studies have identified a population of cells recorded in the postsubiculum and the anterior thalamic nucleus (ATN) that discharge as a function of an animal's head direction (HD) in the horizontal plane. The present experiments monitored HD cell activity when rats were confronted with a situation in which di...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.1.49

    authors: Goodridge JP,Taube JS

    更新日期:1995-02-01 00:00:00

  • Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala.

    abstract::The cAMP-responsive element binding protein (CREB) is a transcription factor that regulates synaptic plasticity and memory formation. Studies that have used conditioned fear models have established that CREB is important for the acquisition and consolidation of fear learning. The authors demonstrate that overexpressio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.4.1125

    authors: Jasnow AM,Shi C,Israel JE,Davis M,Huhman KL

    更新日期:2005-08-01 00:00:00

  • Hippocampal and amygdaloid involvement in nonspatial and spatial working memory in rats: effects of delay and interference.

    abstract::Parametric manipulations of the task demand were used to examine the role of the hippocampus and amygdala in nonspatial and spatial working memory in rats. Hippocampal lesions produced an immediate and long-lasting impairment of nonspatial working memory in an operant task. The memory deficits increased as the delay i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.5.866

    authors: Wan RQ,Pang K,Olton DS

    更新日期:1994-10-01 00:00:00

  • Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

    abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026461

    authors: Chisholm NC,Juraska JM

    更新日期:2012-02-01 00:00:00

  • Analysis of learning deficits in aged rats on the W-track continuous spatial alternation task.

    abstract::Young and aged animals were tested on a spatial alternation task that consisted of two interleaved components: (1) an "outbound" or alternation component (working memory) and (2) an "inbound" component, requiring the animal to remember to return to a central location in space (spatial memory). In the present study, ag...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000269

    authors: Kapellusch AJ,Lester AW,Schwartz BA,Smith AC,Barnes CA

    更新日期:2018-12-01 00:00:00

  • Repeated fluoxetine administration during adolescence stimulates aggressive behavior and alters serotonin and vasopressin neural development in hamsters.

    abstract::Fluoxetine is the only selective serotonin reuptake inhibitor registered for the treatment of major depressive disorder in pediatric populations, despite reports that it is disproportionately associated with an array of adverse side effects that include agitation, hostility, and overt acts of pathological aggression a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0029761

    authors: Ricci LA,Melloni RH Jr

    更新日期:2012-10-01 00:00:00

  • Influence of opioid peptides on learning and memory processes in the chick.

    abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.2.429

    authors: Patterson TA,Schulteis G,Alvarado MC,Martinez JL Jr,Bennett EL,Rosenzweig MR,Hruby VJ

    更新日期:1989-04-01 00:00:00

  • Muscarinic cholinergic neuromodulation reduces proactive interference between stored odor memories during associative learning in rats.

    abstract::Previous electrophysiological studies and computational modeling suggest the hypothesis that cholinergic neuromodulation may reduce olfactory associative interference during learning (M. E. Hasselmo, B. P. Anderson, & J. M. Bower, 1992; M. E. Hasselmo & J. M. Bower, 1993). These results provide behavioral evidence sup...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: De Rosa E,Hasselmo ME

    更新日期:2000-02-01 00:00:00

  • An accessory sex gland aggression-promoting chemosignal in male mice.

    abstract::The present study investigated male murine accessory sex glands as potential sources of a urinary aggression-promoting chemosignal. Experiments 1-4 were designed to determine whether the removal of the following glands would eliminate voided urine chemosignal activity: vesicular and coagulating glands, Cowper's gland,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.5.777

    authors: Ingersoll DW,Morley KT,Benvenga M,Hands C

    更新日期:1986-10-01 00:00:00

  • Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.

    abstract::The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.5.1006

    authors: Rhodes JS,van Praag H,Jeffrey S,Girard I,Mitchell GS,Garland T Jr,Gage FH

    更新日期:2003-10-01 00:00:00

  • The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience.

    abstract::Exposure to an acute stressful event enhances trace eyeblink conditioning in male rats, even when rats begin training days after the stressor (Shors, 2001). The authors examined whether the bed nucleus of the stria terminalis (BNST), an area involved in stress and anxiety, is critically involved in this effect and, if...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.6.1459

    authors: Bangasser DA,Santollo J,Shors TJ

    更新日期:2005-12-01 00:00:00

  • The "proactive" model of learning: Integrative framework for model-free and model-based reinforcement learning utilizing the associative learning-based proactive brain concept.

    abstract::Reinforcement learning (RL) is a powerful concept underlying forms of associative learning governed by the use of a scalar reward signal, with learning taking place if expectations are violated. RL may be assessed using model-based and model-free approaches. Model-based reinforcement learning involves the amygdala, th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000116

    authors: Zsuga J,Biro K,Papp C,Tajti G,Gesztelyi R

    更新日期:2016-02-01 00:00:00

  • Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.

    abstract::In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.4.489

    authors: Dunnett SB,Ryan CN,Levin PD,Reynolds M,Bunch ST

    更新日期:1987-08-01 00:00:00

  • Auditory streaming by phase relations between components of harmonic complexes: a comparative study of human subjects and bird forebrain neurons.

    abstract::Auditory streaming describes a percept in which a sequential series of sounds either is segregated into different streams or is integrated into one stream based on differences in their spectral or temporal characteristics. This phenomenon has been analyzed in human subjects (psychophysics) and European starlings (neur...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0030249

    authors: Dolležal LV,Itatani N,Günther S,Klump GM

    更新日期:2012-12-01 00:00:00

  • Sustained potential shifts in the toad tectum reflect prey-catching and avoidance behavior.

    abstract::Sustained potential shifts (SPS) were recorded for 10 s from the surface of the optic tectum of toads presented with live prey and moving artificial prey stimuli. On the anterior tectal surface, a negative SPS was followed by a positive wave; the converse was true for the posterior tectum. Some animals were immobilize...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.1.150

    authors: Laming PR,Ocherashvili IV,Nicol AU,Roughan JV,Laming BA

    更新日期:1995-02-01 00:00:00

  • Cardiovascular mediation of clonidine-induced ultrasound production in infant rats.

    abstract::In infant rats, administration of the alpha2 adrenoceptor agonist clonidine simultaneously evokes ultrasound production and bradycardia. In this study the authors examined in 8-day-old rats whether these 2 responses to clonidine are causally related. In Experiment 1 pups were pretreated with saline or prenalterol (0.1...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Blumberg MS,Kreber LA,Sokoloff G,Kent KJ

    更新日期:2000-06-01 00:00:00

  • Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice.

    abstract::Previous research emphasized the impact of traumatic brain injury on cholinergic systems and associated cognitive functions. Here we addressed the converse question: Because of the available evidence indicating cognitive and neuronal vulnerabilities in humans expressing low-capacity cholinergic systems or with declini...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000310

    authors: Koshy Cherian A,Tronson NC,Parikh V,Kucinski A,Blakely RD,Sarter M

    更新日期:2019-08-01 00:00:00

  • Time-based prospective memory impairment in patients with thalamic stroke.

    abstract::The role of the thalamus in memory is potentially very complex. However, most studies on the memory impairments of thalamic lesions have focused on retrospective memory, rarely on prospective memory. To explore the effect of thalamic lesions on event-based prospective memory (EBPM) and time-based prospective memory (T...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0018306

    authors: Cheng H,Tian Y,Hu P,Wang J,Wang K

    更新日期:2010-02-01 00:00:00

  • Correlation between head direction cell activity and spatial behavior on a radial arm maze.

    abstract::This study assessed the activity of head direction (HD) cells during performance of a spatial reference memory task on a radial arm maze. Rats were trained to select a maze arm located in a constant position in relation to a salient extramaze visual landmark. HD cell discharge properties remained relatively stable acr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.1.3

    authors: Dudchenko PA,Taube JS

    更新日期:1997-02-01 00:00:00

  • Female túngara frogs do not experience the continuity illusion.

    abstract::In humans and some nonhuman vertebrates, a sound containing brief silent gaps can be rendered perceptually continuous by inserting noise into the gaps. This so-called "continuity illusion" arises from a phenomenon known as "auditory induction" and results in the perception of complete auditory objects despite fragment...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000115

    authors: Baugh AT,Ryan MJ,Bernal XE,Rand AS,Bee MA

    更新日期:2016-02-01 00:00:00

  • Role of instrumental learning in tolerance to cathinone hypophagia.

    abstract::The effects of dl-cathinone on milk intake and motor activity were investigated in bottle- and cannula-fed rats. Acute injections of cathinone produced dose-dependent increases in activity in both groups but only produced decreased intake in bottle-fed rats. With chronic injections, tolerance to the suppression of int...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.2.362

    authors: Wolgin DL,Munoz JR

    更新日期:2006-04-01 00:00:00

  • Effects of benzodiazepine receptor ligands on the ingestion of sucrose, intralipid, and maltodextrin: an investigation using a microstructural analysis of licking behavior in a brief contact test.

    abstract::Microstructural analysis of licking behavior in the rat was conducted (a) to describe in detail the characteristics of benzodiazepine-induced changes in ingestion and (b) to determine if the changes are consistent with an alteration in palatability. The effects of the benzodiazepine receptor (BZR) agonist midazolam (0...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.2.447

    authors: Higgs S,Cooper SJ

    更新日期:1998-04-01 00:00:00

  • Dopaminergic activity modulation via aggression, status, and a visual social signal.

    abstract::Social interaction may elicit aggression, establish social rank, and be influenced by changes in central dopaminergic activity. In the lizard Anolis carolinensis, a sign stimulus (darkening of postorbital skin or eyespots) inhibits aggressive response from opponents, in part because it forms more rapidly in dominant m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.1.93

    authors: Korzan WJ,Forster GL,Watt MJ,Summers CH

    更新日期:2006-02-01 00:00:00