Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.


:Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental memory for emotional stimuli were assessed in 20 healthy volunteers (10 female). Triazolam reduced the normally facilitative effect of emotion on memory. The drug specifically affected memory for the gist of stimuli while leaving detail memory relatively unaffected. This pattern of performance is similar to that seen in patients with amygdala damage. Results suggest an effect of GABAergic neurotransmission at the level of the amygdala on memory modulation.


Behav Neurosci


Behavioral neuroscience


Buchanan TW,Karafin MS,Adolphs R




Has Abstract


2003-06-01 00:00:00












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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Le Marec N,Lalonde R

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Godsil BP,Stefanacci L,Fanselow MS

    更新日期:2005-10-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Scheidler MG,Verbalis JG,Stricker EM

    更新日期:1994-02-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


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    更新日期:1997-12-01 00:00:00

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    abstract::Four experiments studied the opioid receptor subtype and signal transduction mechanisms mediating fear extinction in the ventrolateral quadrant of the midbrain periaqueductal gray (vlPAG). Microinjection of a mu- but not a delta- or kappa-opioid receptor antagonist into the vlPAG retarded extinction. Extinction was al...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: McNally GP,Lee BW,Chiem JY,Choi EA

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dana RC,Martinez JL Jr

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    abstract::The relative influence of morphine microinjected into the periaqueductal gray, ventral medulla (nucleus raphé magnus or nucleus reticularis gigantocellularis), or spinal subarachnoid space on the thresholds of responses organized at spinal (spinal motor reflexes, SMRs), medullary (vocalizations elicited during shock, ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Borszcz GS

    更新日期:1995-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Eacott MJ,Norman G,Gaffan EA

    更新日期:2003-12-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sahley CL,Martin KA,Gelperin A

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    authors: Martin LA,Goldowitz D,Mittleman G

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    pub_type: 杂志文章


    authors: Steidl S,Li L,Yeomans JS

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    pub_type: 杂志文章


    authors: Factor EM,Mayer AD,Rosenblatt JS

    更新日期:1993-02-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Agmo A,Gómez M

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    pub_type: 杂志文章


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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lett BT

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Duesenberg M,Weber J,Schaeuffele C,Fleischer J,Hellmann-Regen J,Roepke S,Moritz S,Otte C,Wingenfeld K

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Williams CL

    更新日期:1987-10-01 00:00:00

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    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kaplan JM,Seeley RJ,Grill HJ

    更新日期:1994-04-01 00:00:00