Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.

Abstract:

:Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental memory for emotional stimuli were assessed in 20 healthy volunteers (10 female). Triazolam reduced the normally facilitative effect of emotion on memory. The drug specifically affected memory for the gist of stimuli while leaving detail memory relatively unaffected. This pattern of performance is similar to that seen in patients with amygdala damage. Results suggest an effect of GABAergic neurotransmission at the level of the amygdala on memory modulation.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Buchanan TW,Karafin MS,Adolphs R

doi

10.1037/0735-7044.117.3.517

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

517-25

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

117

pub_type

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