Abstract：
:Preadolescent mice have been shown to be differentially susceptible to the effects of both acute and chronic nicotine exposure on contextual fear learning relative to adults. For this study, we tested the effects of chronic nicotine exposure in preadolescence on adulthood extinction and spontaneous recovery of fear memory in a model in which contextual fear acquisition occurred prior to nicotine exposure. Preadolescent (postnatal day 23) and adult (postnatal day 53) male C57BL/6J mice underwent contextual fear conditioning and were then exposed to chronic nicotine at 12.6 mg/kg/day for 12 days via osmotic minipump. Eighteen days following the removal of nicotine, both groups of mice underwent fear extinction, followed by a spontaneous recovery session a week later. History of chronic nicotine did not affect later extinction of fear memory in adult-trained mice, whereas adolescent-trained mice exhibited a global impairment in retention of fear memory that precluded detection of effects of early nicotine on later fear extinction. However, it was found that adult spontaneous recovery of fear memory was impaired in mice exposed to nicotine as adults and enhanced in mice exposed to nicotine as preadolescents. These results may indicate greater vulnerability to recurrence of traumatic memory as well as compromised inhibitory control in young smokers. (PsycINFO Database Record
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Zeid D,Gould TJdoi
10.1037/bne0000247subject
Has Abstractpub_date
2018-08-01 00:00:00pages
240-246issue
4eissn
0735-7044issn
1939-0084pii
2018-31260-001journal_volume
132pub_type
杂志文章abstract：:Two preparations in which sensory nerve stimulation was used to obtain peripherally induced spinal fixation in spinal rats are described. In the first preparation, proportionally greater amounts of persisting poststimulation flexor muscle contraction, as measured by a force displacement transducer, were produced as st...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/h0092460
更新日期：1985-02-01 00:00:00
abstract：:One-month-old rats were fed 1 of 4 high-fat diets (20% fat) or chow (4.5% fat) for 3 months. Dietary saturated (SFA), monounsaturated (MUFA), or polyunsaturated (PUFA) fatty acids varied such that their independent effects on cognitive performance could be tested. Rats were tested on a variable-interval delayed-altern...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.110.3.451
更新日期：1996-06-01 00:00:00
abstract：:Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such transformative tool in behavioral neuroscience research, chemogenetics (or Designer Receptors Exclusively Activated by Designer Drugs, DREADDS). As transformative tec...
journal_title：Behavioral neuroscience
pub_type： 杂志文章,评审
doi：10.1037/bne0000135
更新日期：2016-04-01 00:00:00
abstract：:Galanin is a 29-amino-acid neuropeptide that is overexpressed in Alzheimer's disease (AD) and impairs performance on rodent learning and memory tasks. M40, a peptidergic galanin receptor ligand, blocks galanin-induced impairments on delayed non-matching-to-position (DNMTP). The present experiments used the 192IgG-sapo...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.111.3.552
更新日期：1997-06-01 00:00:00
abstract：:This experiment was conducted to determine whether the amount of preoperative training influences the effects, on retention, of amygdala lesions induced 30 days after escape training. Rats received 1 or 10 footshock-motivated escape training trials; 30 days later, sham or neurotoxic amygdala lesions were induced. Resu...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.108.6.1080
更新日期：1994-12-01 00:00:00
abstract：:Bilateral peripeduncular (PPN) lesions made on the seventh postpartum day (L7) with either radiofrequency (RF) current or N-methyl-d,l-aspartic acid (NMDA)/phosphate buffered saline (PBS) reduced maternal aggression (MA) and partially inhibited lactation without producing significant deficits in other items of materna...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.107.1.166
更新日期：1993-02-01 00:00:00
abstract：:Classical conditioning is known to induce frequency-specific receptive field (RF) plasticity in the auditory cortex (ACx). This study determined the effects of discrimination training on RFs at two levels of task difficulty. Single unit and cluster discharges were recorded in the ACx of adult guinea pigs trained in a ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.107.1.82
更新日期：1993-02-01 00:00:00
abstract：:To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/0735-7044.120.2.477
更新日期：2006-04-01 00:00:00
abstract：:New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls con...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.109.2.195
更新日期：1995-04-01 00:00:00
abstract：:Female rats drink more 3% NaCl solution than do males, both when they need sodium (need-induced sodium intake or sodium appetite) and when they do not (need-free sodium intake). The sexual dimorphism of sodium intake is a secondary sexual characteristic because after castration at 1 day of age male rats drank 3% NaCl ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.106.1.172
更新日期：1992-02-01 00:00:00
abstract：:Acetylcholine (ACh) and noradrenaline (NA) release in the olfactory bulb (OB) of ewes was monitored using microdialysis. Both ACh and NA release increased at parturition in multiparous but not in primiparous ewes. However, vaginocervical stimulation performed 6 hr postpartum induced an increase of ACh and NA release i...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.107.4.662
更新日期：1993-08-01 00:00:00
abstract：:Neuropeptide Y (NPY) is a potent endogenous stimulator of food intake. In addition to stimulating increased food intake, when paired with a novel-flavored solution, NPY produces an aversion to that flavor. Hence, exogenous NPY elicits 2 seemingly opposing behaviors, increased feeding and the formation of a conditioned...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：:Environmental cues associated with drug administration elicit neural activation in circuits involved in cognitive processes and emotional regulation. An important question is whether the neural activation observed is specific to the drug-paired environment or is due to a generalized activation induced by previous drug...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.116.4.727
更新日期：2002-08-01 00:00:00
abstract：:The role of the pedunculopontine tegmental nucleus (PPTg) in stimulus-reward learning was assessed by testing the effects of PPTg lesions on performance in visual autoshaping and conditioned reinforcement (CRf) paradigms. Rats with PPTg lesions were unable to learn an association between a conditioned stimulus (CS) an...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.114.2.285
更新日期：2000-04-01 00:00:00
abstract：:A microstructural analysis of the licking behavior of the rat was used to investigate the effects of total abdominal vagotomy on ingestive behavior. Vagotomy decreased the meal size of milk and 3 concentrations of sucrose. The decrease was due to an increase in the decline in the rate of licking during the meal, sugge...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Cardiac patterns of startle and orienting in response to auditory and vibrotactile stimuli were investigated in the infant chimpanzee and gorilla. Results revealed a notable cardiac acceleration in response to the initial presentations of stimuli of either modality. This acceleratory response appeared to reflect the c...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.98.5.914
更新日期：1984-10-01 00:00:00
abstract：:This study determined the effects of estrogen loss and replacement therapy on learning and memory function in monkeys (Macaca fascicularis). The ability to learn, remember, and perform reversals of object discriminations and the accuracy on a spatial delayed response task were found to be comparable in young adult sur...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.103.1.170
更新日期：1989-02-01 00:00:00
abstract：:Sexually experienced female rats return to the male more quickly after intromissions, exhibit shorter interintromission intervals, and spend more time with the male rat during a test of paced mating behavior in comparison to naïve rats. The present study tested whether these changes reflect heightened sexual motivatio...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/bne0000163
更新日期：2016-10-01 00:00:00
abstract：:Rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) and sham-operated rats were trained in either a simple discrimination paradigm assessing simple association learning or a negative patterning paradigm assessing configural association learning. In the simple discrimination task, rats were r...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.116.2.241
更新日期：2002-04-01 00:00:00
abstract：:Conditioned inhibition (CI) of the rat eyeblink response and the neuronal correlates of CI in the cerebellar interpositus nucleus were examined in the present study. In Experiment 1, CI was established with a novel, 3-group design. In Experiment 2, neuronal activity in the anterior interpositus nucleus was recorded du...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：:Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.111.1.214
更新日期：1997-02-01 00:00:00
abstract：:Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether thi...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0029699
更新日期：2012-10-01 00:00:00
abstract：:In order to examine the development of tolerance to opioids, eight cynomolgus and two rhesus monkeys were trained to press a lever for food reinforcement and then were catheterized so that drugs could be infused. Three doses of hydromorphone and six different interdose intervals were studied. Hydromorphone infusions i...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.97.2.327
更新日期：1983-04-01 00:00:00
abstract：:The current study examined possible interactions between genetic factors and prolonged drug access by testing the Fischer (F344), Lewis (LEW), and Wistar rat strains in a prolonged access cocaine self-administration (SA) procedure. Before prolonged access, the strains did not differ in breakpoints for food or cocaine ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/a0013727
更新日期：2009-02-01 00:00:00
abstract：:In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037//0735-7044.101.4.489
更新日期：1987-08-01 00:00:00
abstract：:The aim of this study was to investigate the effects of postnatal choline supplementation on neurochemical and behavioral parameters in preweanling BALB/cByJ mice. Mouse pups were injected daily subcutaneously with choline chloride (0.85 mM/g body weight) from Postnatal Day (PND) 1 to PND 16. Pups performed a passive ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The retrosplenial cortex is strongly connected with brain regions involved in spatial signaling. To test whether it also codes space, single cells were recorded while rats navigated in an open field. As in earlier work (L. L. Chen, L. H. Lin, C. A. Barnes, & B. L. McNaughton, 1994; L. L. Chen, L. H. Lin, E. J. Green, ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：10.1037/0735-7044.115.1.3
更新日期：2001-02-01 00:00:00
abstract：:The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:A differentiation was made between dispositional memory and representational memory. A delayed-nonmatching-to-sample task in a T-maze operationalized this distinction. Experimental brain lesions in posterior septum and in prelimbic cortex resulted in amnesia for representational memories. The amnesia ameliorated as a ...
journal_title：Behavioral neuroscience
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
