Abstract:
:Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-month-old +/Lc mice to a delayed spontaneous alternation task to test their working and long-term spatial memories. Results show that wild type (+/+) mice alternated above chance even after a 1-hr delay between the forced and choice trials, whereas in +/Lc mice, long-term memory was impaired. Cerebellectomized +/+ mice behave as +/Lc mice (working memory was preserved but long-term memory was not), whereas in the cerebellectomized +/Lc mice, both working and long-term memories were altered. These results are discussed in terms of relationships between the cerebellum and the hippocampus.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Caston J,Vasseur F,Delhaye-Bouchaud N,Mariani Jdoi
10.1037//0735-7044.111.1.214subject
Has Abstractpub_date
1997-02-01 00:00:00pages
214-8issue
1eissn
0735-7044issn
1939-0084journal_volume
111pub_type
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