Fimbria-fornix transections disrupt the ontogeny of delayed alternation but not position discrimination in the rat.

Abstract:

:In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the PD task within five 12-trial blocks of training. However, only sham-operated pups learned the DA task. In Experiment 2, performance of DA emerged between PND19 and PND27 in sham-operated pups but failed entirely to develop in pups with early lesions. In Experiment 3, fornix-transected pups that were given extended DA training (132 trials) on PND23-PND24 showed some improvement in performance but remained impaired in relation to sham-operated controls. These findings implicate the limbic system in the postnatal development of DA but not PD and suggest that dual-process theories of memory may be relevant to the psychobiology of cognitive development.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Freeman JH Jr,Stanton ME

doi

10.1037//0735-7044.105.3.386

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

386-95

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

105

pub_type

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