Abstract:
:This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intracerebroventricular injections of either vehicle or 20 micrograms of alpha-helical CRF(9-41), a CRF receptor antagonist. After 20 min, rats were reexposed to the open field, which now contained odors of urine and feces from a stressed conspecific. In the reexposure test, vehicle- and antagonist-treated rats withdrew rapidly into the chamber. Antagonist-treated rats, however, emerged subsequently from the chamber to explore the open field as indicated by a significant increase in the number of passages made between the chamber and the open field. Results suggest that central injection of alpha-helical CRF(9-41) reduces the level of fear induced by odors associated with threat. In addition, CRF receptors are implicated in mediating the species-typical display of defensive-withdrawal behavior.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Takahashi LK,Kalin NH,Baker EWdoi
10.1037//0735-7044.104.2.386subject
Has Abstractpub_date
1990-04-01 00:00:00pages
386-9issue
2eissn
0735-7044issn
1939-0084journal_volume
104pub_type
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