Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.

Abstract:

:This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intracerebroventricular injections of either vehicle or 20 micrograms of alpha-helical CRF(9-41), a CRF receptor antagonist. After 20 min, rats were reexposed to the open field, which now contained odors of urine and feces from a stressed conspecific. In the reexposure test, vehicle- and antagonist-treated rats withdrew rapidly into the chamber. Antagonist-treated rats, however, emerged subsequently from the chamber to explore the open field as indicated by a significant increase in the number of passages made between the chamber and the open field. Results suggest that central injection of alpha-helical CRF(9-41) reduces the level of fear induced by odors associated with threat. In addition, CRF receptors are implicated in mediating the species-typical display of defensive-withdrawal behavior.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Takahashi LK,Kalin NH,Baker EW

doi

10.1037//0735-7044.104.2.386

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

386-9

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

104

pub_type

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