Medial dorsal thalamic lesions impair blocking and latent inhibition of the conditioned eyeblink response in rats.

Abstract:

:The effects of lesions of the medial dorsal thalamic nucleus (MD) on blocking and latent inhibition (LI) of the rat eyeblink response were examined in the present study. Previous work has demonstrated that the cingulate cortex and related thalamic areas are involved in processing conditioning stimuli throughout training. The experiments in the present study tested the hypothesis that disruption of cingulothalamic stimulus processing produced by lesions of the MD would impair 2 types of associative learning that involve decremental changes in attention. In Experiment 1, MD lesions severely impaired blocking. In Experiment 2, MD lesions severely impaired LI. The results indicate that lesions of the MD impair incremental, decremental, or both types of changes in stimulus processing during learning.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Nicholson DA,Freeman JH Jr

doi

10.1037//0735-7044.116.2.276

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

276-85

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

116

pub_type

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