Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.


:New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls consisted of time-matched sham-operated and neocortical aspirated rabbits. When retested on the trace paradigm, rabbits with hippocampal aspirations 1 day after learning were significantly and substantially impaired in the retention of trace conditioned responses. In contrast, rabbits that received hippocampal aspirations 1 month after training retained trace conditioned responses at a level comparable to that of the controls. Moreover, hippocampectomy had no effect on the retention of delay eyeblink conditioning. Thus, the hippocampus appears to be necessary for the retention of recently acquired, but not remotely acquired, trace conditioned responses.


Behav Neurosci


Behavioral neuroscience


Kim JJ,Clark RE,Thompson RF




Has Abstract


1995-04-01 00:00:00












  • Environmental enrichment as a therapy for autism: A clinical trial replication and extension.

    abstract::Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,随机对照试验


    authors: Woo CC,Donnelly JH,Steinberg-Epstein R,Leon M

    更新日期:2015-08-01 00:00:00

  • Odors can induce feeding motor responses in the terrestrial mollusc Limax maximus.

    abstract::Highly developed odor learning was shown in the terrestrial slug Limax maximus. In addition, several key cellular elements of the neural network that controls ingestive feeding have been identified. The results of 3 experiments demonstrate an interaction between odor input and ingestive feeding in that olfactory stimu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sahley CL,Martin KA,Gelperin A

    更新日期:1992-06-01 00:00:00

  • Hippocampal growth and maintenance depend on food-caching experience in juvenile mountain chickadees (Poecile gambeli).

    abstract::This experiment investigated the development of caching behavior and the hippocampus (HF) in postfledging mountain chickadees (Poecile gambeli). From Days 35 to 53, the number of seeds stored increased but the proportion recovered did not. Birds that stored and recovered during 3 or more trials had significantly enlar...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Clayton NS

    更新日期:2001-06-01 00:00:00

  • Visual asymmetries in Japanese quail (Coturnix japonica) retain a lifelong potential for plasticity.

    abstract::Adult Japanese quail display left-eye/right-hemisphere dominance in visually guided sexual tracking. In 2 experiments, the authors set out to answer if this functional cerebral asymmetry is modifiable by posthatch monocular deprivation. In Experiment 1, the left or the right eye of 2-day old quail were closed for 70 d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Gülbetekin E,Güntürkün O,Dural S,Cetinkaya H

    更新日期:2009-08-01 00:00:00

  • The "proactive" model of learning: Integrative framework for model-free and model-based reinforcement learning utilizing the associative learning-based proactive brain concept.

    abstract::Reinforcement learning (RL) is a powerful concept underlying forms of associative learning governed by the use of a scalar reward signal, with learning taking place if expectations are violated. RL may be assessed using model-based and model-free approaches. Model-based reinforcement learning involves the amygdala, th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Zsuga J,Biro K,Papp C,Tajti G,Gesztelyi R

    更新日期:2016-02-01 00:00:00

  • A comparison of the short- and long-term effects of corticosterone exposure on extinction in adolescence versus adulthood.

    abstract::Human and nonhuman adolescents have impaired retention of extinction of learned fear, relative to juveniles and adults. It is unknown whether exposure to stress affects extinction differently in adolescents versus adults. These experiments compared the short- and long-term effects of exposure to the stress-related hor...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Den ML,Altmann SR,Richardson R

    更新日期:2014-12-01 00:00:00

  • Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).

    abstract::Female songbirds use male songs as an important criterion for mate selection. Several studies have reported that female songbirds prefer complex songs to other song types. In a recent study, the authors found that song responsiveness in female zebra finches (Taeniopygia guttata) is strongly modulated by circulating es...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Vyas A,Harding C,McGowan J,Snare R,Bogdan D

    更新日期:2008-10-01 00:00:00

  • Bilateral nature of the conditioned eyeblink response in the rabbit: behavioral characteristics and potential mechanisms.

    abstract::In Pavlovian eyeblink conditioning, the conditioned response (CR) is highly lateralized to the eye to which the unconditioned stimulus (US) has been directed. However, the initial conditioning of one eye can facilitate subsequent conditioning of the other eye, a phenomenon known as the intereye transfer (IET) effect. ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lee T,Kim JJ,Wagner AR

    更新日期:2008-12-01 00:00:00

  • Effects of excitotoxic lesions of the central amygdaloid nucleus on the potentiation of reward-related stimuli by intra-accumbens amphetamine.

    abstract::The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 microg/microl). Rats were trained to associate a light-plus-noise ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robledo P,Robbins TW,Everitt BJ

    更新日期:1996-10-01 00:00:00

  • Response-reinforcer associations after caudate-putamen lesions in the rat: spatial discrimination and overshadowing-potentiation effects in instrumental learning.

    abstract::Experiment 1 demonstrated that rats with caudate-putamen lesions show an impairment in the acquisition and reversal of a spatial maze task when compared with unoperated control subjects. Experiment 2 examined lever-press responding supported by a variable interval schedule in three groups of subjects: a group with cau...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Mitchell JA,Channell S,Hall G

    更新日期:1985-12-01 00:00:00

  • Sexual behavior regulated (paced) by the female induces conditioned place preference.

    abstract::The possibility that female-paced coital behavior induces a reward state of sufficient intensity and duration to induce conditioning was evaluated by the conditioned-place-preference paradigm. Ovariectomized female rats, treated with estradiol benzoate and progesterone, regulated (paced) their coital interactions with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Paredes RG,Alonso A

    更新日期:1997-02-01 00:00:00

  • Cross-modal savings in the contralateral eyelid conditioned response.

    abstract::The present experiment monitored bilateral eyelid responses during eyeblink conditioning in rats trained with a unilateral unconditioned stimulus (US). Three groups of rats were used to determine if cross-modal savings occurs when the location of the US is switched from one eye to the other. Rats in each group first r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Campolattaro MM,Buss EW,Freeman JH

    更新日期:2015-12-01 00:00:00

  • Effects of hydrocortisone on false memory recognition in healthy men and women.

    abstract::Most of the studies focusing on the effect of stress on false memories by using psychosocial and physiological stressors yielded diverse results. In the present study, we systematically tested the effect of exogenous hydrocortisone using a false memory paradigm. In this placebo-controlled study, 37 healthy men and 38 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Duesenberg M,Weber J,Schaeuffele C,Fleischer J,Hellmann-Regen J,Roepke S,Moritz S,Otte C,Wingenfeld K

    更新日期:2016-12-01 00:00:00

  • The role of hippocampal subregions in detecting spatial novelty.

    abstract::Previous literature suggests that the hippocampus subserves processes associated with the encoding of novel information. To investigate the role of different subregions of the hippocampus, the authors made neurotoxic lesions in different subregions of the dorsal hippocampus (i.e., CA1, dentate gyrus [DG], or CA3) of r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lee I,Hunsaker MR,Kesner RP

    更新日期:2005-02-01 00:00:00

  • Medial dorsal thalamic lesions impair blocking and latent inhibition of the conditioned eyeblink response in rats.

    abstract::The effects of lesions of the medial dorsal thalamic nucleus (MD) on blocking and latent inhibition (LI) of the rat eyeblink response were examined in the present study. Previous work has demonstrated that the cingulate cortex and related thalamic areas are involved in processing conditioning stimuli throughout traini...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Nicholson DA,Freeman JH Jr

    更新日期:2002-04-01 00:00:00

  • Time-based prospective memory impairment in patients with thalamic stroke.

    abstract::The role of the thalamus in memory is potentially very complex. However, most studies on the memory impairments of thalamic lesions have focused on retrospective memory, rarely on prospective memory. To explore the effect of thalamic lesions on event-based prospective memory (EBPM) and time-based prospective memory (T...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Cheng H,Tian Y,Hu P,Wang J,Wang K

    更新日期:2010-02-01 00:00:00

  • Auditory streaming by phase relations between components of harmonic complexes: a comparative study of human subjects and bird forebrain neurons.

    abstract::Auditory streaming describes a percept in which a sequential series of sounds either is segregated into different streams or is integrated into one stream based on differences in their spectral or temporal characteristics. This phenomenon has been analyzed in human subjects (psychophysics) and European starlings (neur...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dolležal LV,Itatani N,Günther S,Klump GM

    更新日期:2012-12-01 00:00:00

  • Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

    abstract::Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Francis HM,Stevenson RJ

    更新日期:2011-12-01 00:00:00

  • Pelvic and pudendal nerves influence the display of paced mating behavior in response to estrogen and progesterone in the female rat.

    abstract::Two experiments examined whether the pudendal and pelvic autonomic nerves are important for pacing behavior shown by the female rat during mating. Ovariectomized female rats received bilateral transection of the pudendal (Pux), pelvic (Pex), or pudendal and pelvic (Pu + Pex) nerves or were sham-operated (Shx). Lordoti...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Erskine MS

    更新日期:1992-08-01 00:00:00

  • Click-evoked otoacoustic emissions: response amplitude is associated with circulating testosterone levels in men.

    abstract::In rhesus monkeys, the magnitude of the cochlear response to auditory stimuli (click-evoked otoacoustic emissions, [CEOAEs]) is correlated with seasonal changes in circulating testosterone levels. The present study investigated the association between circulating testosterone and CEOAE production in men. CEOAEs were m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Snihur AW,Hampson E

    更新日期:2012-04-01 00:00:00

  • Association of an odor with activation of olfactory bulb noradrenergic beta-receptors or locus coeruleus stimulation is sufficient to produce learned approach responses to that odor in neonatal rats.

    abstract::These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenergic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-recepto...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sullivan RM,Stackenwalt G,Nasr F,Lemon C,Wilson DA

    更新日期:2000-10-01 00:00:00

  • Fixation of spinal reflex alterations in spinal rats by sensory nerve stimulation.

    abstract::Two preparations in which sensory nerve stimulation was used to obtain peripherally induced spinal fixation in spinal rats are described. In the first preparation, proportionally greater amounts of persisting poststimulation flexor muscle contraction, as measured by a force displacement transducer, were produced as st...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Steinmetz JE,Patterson MM

    更新日期:1985-02-01 00:00:00

  • Perinatal stress effects on later anxiety and hormone secretion in male mandarin voles.

    abstract::The estradiol (E2), estrogen receptor-α (ERα), testosterone (T), and androgen receptor (AR) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. Here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: He FQ,Fang G,Wang B,Guo XJ,Guo CL

    更新日期:2015-12-01 00:00:00

  • Mnemonic theories of hippocampal function.

    abstract::Although mnemonic interpretations of hippocampal function in people have been readily accepted for many years, similar interpretations of hippocampal function in animals have received a number of challenges. This article reviews two of these challenges, shows how they were resolved in favor of some kind of mnemonic in...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Olton DS,Wible CG,Shapiro ML

    更新日期:1986-12-01 00:00:00

  • Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.

    abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robinson-Drummer PA,Dokovna LB,Heroux NA,Stanton ME

    更新日期:2016-04-01 00:00:00

  • Context-specific habituation of the freezing response in newborn chicks.

    abstract::Previous studies have found that in mature animals habituation is context-specific in some species but not in others. Given the mixed evidence present in the literature, we decided to explore whether habituation is context-specific in newborn chicks. The results showed that 3 days after hatching, chicks were capable o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Chiandetti C,Turatto M

    更新日期:2017-10-01 00:00:00

  • Interaction between recovery from behavioral asymmetries induced by hemivibrissotomy in the rat and the effects of apomorphine and amphetamine.

    abstract::Spontaneous and drug-induced turning behavior and thigmotactic scanning were tested either acutely (4-6 hr) or chronically (9 days) after unilateral removal of vibrissae in rats. Rats that were tested acutely scanned more with the intact vibrissae side. This asymmetry was reduced in rats that were tested chronically, ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Milani H,Schwarting RK,Kumpf S,Steiner H,Huston JP

    更新日期:1990-06-01 00:00:00

  • Role of instrumental learning in tolerance to cathinone hypophagia.

    abstract::The effects of dl-cathinone on milk intake and motor activity were investigated in bottle- and cannula-fed rats. Acute injections of cathinone produced dose-dependent increases in activity in both groups but only produced decreased intake in bottle-fed rats. With chronic injections, tolerance to the suppression of int...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wolgin DL,Munoz JR

    更新日期:2006-04-01 00:00:00

  • Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats.

    abstract::The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Steidl S,Li L,Yeomans JS

    更新日期:2001-06-01 00:00:00

  • Distinct roles for striatal subregions in mediating response processing revealed by focal excitotoxic lesions.

    abstract::This study examined the relative roles of distinct striatal areas in response processing. Rats were trained on a reaction time task that enabled performance on each side of the rat's body to be assessed independently. Rats then received unilateral lesions of the whole dorsal striatum or restricted medial or lateral le...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Brasted PJ,Robbins TW,Dunnett SB

    更新日期:1999-04-01 00:00:00