Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.

Abstract:

:New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls consisted of time-matched sham-operated and neocortical aspirated rabbits. When retested on the trace paradigm, rabbits with hippocampal aspirations 1 day after learning were significantly and substantially impaired in the retention of trace conditioned responses. In contrast, rabbits that received hippocampal aspirations 1 month after training retained trace conditioned responses at a level comparable to that of the controls. Moreover, hippocampectomy had no effect on the retention of delay eyeblink conditioning. Thus, the hippocampus appears to be necessary for the retention of recently acquired, but not remotely acquired, trace conditioned responses.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Kim JJ,Clark RE,Thompson RF

doi

10.1037//0735-7044.109.2.195

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

195-203

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

109

pub_type

杂志文章
  • Strain differences in patterns of drug-intake during prolonged access to cocaine self-administration.

    abstract::The current study examined possible interactions between genetic factors and prolonged drug access by testing the Fischer (F344), Lewis (LEW), and Wistar rat strains in a prolonged access cocaine self-administration (SA) procedure. Before prolonged access, the strains did not differ in breakpoints for food or cocaine ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0013727

    authors: Freeman KB,Kearns DN,Kohut SJ,Riley AL

    更新日期:2009-02-01 00:00:00

  • dl-fenfluramine challenge to nutrient-specific textural preference conditioned by concurrent presentation of two diets.

    abstract::Effects of the ingestion of protein and carbohydrate conditioned a preference for one size of chow particle over another, which was triggered by need for a specific nutrient. This learned elicitation of nutrient-specific dietary selection was not changed by injection of dl-fenfluramine HCl (2.5 mg/kg). This indicates ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Booth DA,Baker BJ

    更新日期:1990-02-01 00:00:00

  • Anterior rhinal cortex and amygdala: dissociation of their contributions to memory and food preference in rhesus monkeys.

    abstract::Rhesus monkeys were trained on 2 versions of delayed nonmatching-to-sample, one with multiple pairs of objects and the other with a single pair, to evaluate their ability to remember objects. They then received either bilateral aspiration lesions of the anterior rhinal cortex or bilateral excitotoxic lesions of the am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Murray EA,Gaffan EA,Flint RW Jr

    更新日期:1996-02-01 00:00:00

  • Chronic citalopram treatment ameliorates depressive behavior associated with light at night.

    abstract::Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether thi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0029699

    authors: Bedrosian TA,Weil ZM,Nelson RJ

    更新日期:2012-10-01 00:00:00

  • Mapping the substrate for brain stimulation reward by means of current-number trade-off functions.

    abstract::In previous studies using moveable electrodes to map the substrate for brain stimulation reward, reward effectiveness was estimated by varying either the current or the number of pulses per train. The resulting relationship between reward effectiveness and stimulation site is independent of the fixed parameter only if...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.3.506

    authors: Forgie ML,Shizgal P

    更新日期:1993-06-01 00:00:00

  • Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.

    abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000134

    authors: Robinson-Drummer PA,Dokovna LB,Heroux NA,Stanton ME

    更新日期:2016-04-01 00:00:00

  • The hippocampal memory indexing theory.

    abstract::The hippocampal formation (comprising the hippocampus proper, the dentate gyrus, and the subiculum) has been repeatedly implicated in information storage models of the mammalian brain. The precise nature of the hippocampal role in the storage of information has, however, remained elusive. Here it is proposed that the ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.2.147

    authors: Teyler TJ,DiScenna P

    更新日期:1986-04-01 00:00:00

  • Neuronal correlates of conditioned inhibition of the eyeblink response in the anterior interpositus nucleus.

    abstract::Conditioned inhibition (CI) of the rat eyeblink response and the neuronal correlates of CI in the cerebellar interpositus nucleus were examined in the present study. In Experiment 1, CI was established with a novel, 3-group design. In Experiment 2, neuronal activity in the anterior interpositus nucleus was recorded du...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Nicholson DA,Freeman JH Jr

    更新日期:2002-02-01 00:00:00

  • HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height.

    abstract::Rats with unilateral dopamine (DA) depletion (hemiParkinson analogue rats) are impaired in using the contralateral (bad) limbs for skilled movements and for postural adjustments and compensate by using their good limbs in novel ways. The present study consisted of a reaching task in which compensatory adjustments usin...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.1.117

    authors: Miklyaeva EI,Whishaw IQ

    更新日期:1996-02-01 00:00:00

  • Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

    abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026461

    authors: Chisholm NC,Juraska JM

    更新日期:2012-02-01 00:00:00

  • Learning and retrieval of concurrently presented spatial discrimination tasks: role of the fornix.

    abstract::In macaque monkeys (Macaco mulatta), memory for scenes presented on touch screens is fornix dependent. However, scene learning is not a purely spatial task, and existing direct evidence for a fornix role in spatial memory comes exclusively from tasks involving learning about food-reward locations. Here the authors dem...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.1.138

    authors: Buckley MJ,Charles DP,Browning PG,Gaffan D

    更新日期:2004-02-01 00:00:00

  • The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta).

    abstract::Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less, within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.5.971

    authors: Bussey TJ,Wise SP,Murray EA

    更新日期:2001-10-01 00:00:00

  • Changes in goal selection induced by cue conflicts are in register with predictions from changes in place cell field locations.

    abstract::In the cognitive mapping theory of hippocampal function, currently active place cells represent a rat's spatial location (J. O'Keefe & L. Nadel, 1978). A systematic shift of firing field locations should therefore produce a similar shift in a rat's judgment of its location. A. A. Fenton, G. Csizmadia, and R. U. Muller...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.4.751

    authors: Kubie JL,Fenton A,Novikov N,Touretzky D,Muller RU

    更新日期:2007-08-01 00:00:00

  • Angiotensin and salt appetite: physiological amounts of angiotensin given peripherally increase salt appetite in the rat.

    abstract::Two experiments were conducted in which adrenalectomized male Sprague-Dawley rats were maintained ad lib on distilled water, 3% saline, and sodium-free food. In Experiment 1, 45 rats were given 100, 200, 400, 800, and 1,000 micrograms/kg/day desoxycorticosterone acetate (DOCA) im for 5 days to determine the dose of DO...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.4.597

    authors: Dalhouse AD,Langford HG,Walsh D,Barnes T

    更新日期:1986-08-01 00:00:00

  • Central dopamine turnover in guinea pig pups during separation from their mothers in a novel environment.

    abstract::Guinea pig pups that were separated from their mothers and placed into a novel environment for 90 min showed an increase in dopamine (DA) turnover (ratio of metabolites to DA) in the septum compared with undisturbed baseline controls. Pups placed into the novel environment with their mothers exhibited an intermediate ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.4.607

    authors: Tamborski A,Lucot JB,Hennessy MB

    更新日期:1990-08-01 00:00:00

  • A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preference.

    abstract::Previous work has demonstrated an important role for adrenergic receptors in memory processes in fear and drug conditioning paradigms. Recent studies have also demonstrated alterations in extinction in these paradigms using drug treatments targeting beta- and alpha2-adrenergic receptors, but little is known about the ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0018909

    authors: Bernardi RE,Lattal KM

    更新日期:2010-04-01 00:00:00

  • Drug discrimination training during chronic drug treatment affects the development of tolerance.

    abstract::The purpose of this experiment was to evaluate the extent to which continued drug discrimination training during chronic drug treatment affects the development of tolerance. Rats were trained to discriminate distilled water from 0.75 mg/kg amphetamine in a two-lever drug discrimination task. Two groups were then given...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.2.373

    authors: Caul WF,Burgin KL,Barrett RJ

    更新日期:1989-04-01 00:00:00

  • Behavioral spectral sensitivities of different retinal areas in pigeons.

    abstract::The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.1.170

    authors: Remy M,Emmerton J

    更新日期:1989-02-01 00:00:00

  • The union of the state: myoclonic twitching is coupled with nuchal muscle atonia in infant rats.

    abstract::Active sleep (AS), as measured by the occurrence of myoclonic twitching (MT), is the most prevalent behavioral state in newborn rats. Historically, AS has been considered a developmental precursor of REM sleep, but recently this idea has been questioned. In the present study, the authors assess, in 2-, 5-, and 8-day-o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.5.912

    authors: Karlsson KA,Blumberg MS

    更新日期:2002-10-01 00:00:00

  • Cortico-basal ganglia and cortico-cerebellar circuits in Parkinson's disease: pathophysiology or compensation?

    abstract::The basal ganglia and the cerebellum are anatomically and functionally linked to the cerebral cortex through a series of well-established circuits. The disruption of dopaminergic projections in Parkinson's disease (PD) leads to an imbalance within these circuits, leading to motor and cognitive symptoms. The cortico-ce...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037/a0031226

    authors: Martinu K,Monchi O

    更新日期:2013-04-01 00:00:00

  • Role of the hippocampus plus subjacent cortex but not amygdala in visuomotor conditional learning in rhesus monkeys.

    abstract::Rhesus monkeys were trained to learn a large series of visuomotor conditional associations, each involving the arbitrary coupling of a visual stimulus with 1 of 3 potentially correct forelimb movements. The monkeys then received bilateral aspiration lesions of either the amygdala plus subjacent cortex or the hippocamp...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.6.1261

    authors: Murray EA,Wise SP

    更新日期:1996-12-01 00:00:00

  • Rapid effects of 17β-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX.

    abstract::Estrogens have been shown to rapidly promote male copulatory behaviors with a time-course that suggests rapid signaling events are involved. The present study tested the hypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER). Thus, either estradiol (E2), STX (a diphenylacrylam...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0032950

    authors: Kaufman KR,Kelly MJ,Roselli CE

    更新日期:2013-08-01 00:00:00

  • Long-term memory facilitation in rats by posttraining epinephrine.

    abstract::Effects of posttraining epinephrine (EPI) on retention of a massed (1 session, 30 trials) 2-way active avoidance task in rats were studied. The rats received an injection (ip) of 0.05 mg/kg EPI, 0.01 mg/kg EPI, or distilled water immediately after the training session. EPI did not improve retention 24 hr after the tra...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.3.469

    authors: Costa-Miserachs D,Portell-Cortés I,Aldavert-Vera L,Torras-García M,Morgado-Bernal I

    更新日期:1994-06-01 00:00:00

  • Response-reinforcer associations after caudate-putamen lesions in the rat: spatial discrimination and overshadowing-potentiation effects in instrumental learning.

    abstract::Experiment 1 demonstrated that rats with caudate-putamen lesions show an impairment in the acquisition and reversal of a spatial maze task when compared with unoperated control subjects. Experiment 2 examined lever-press responding supported by a variable interval schedule in three groups of subjects: a group with cau...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.6.1074

    authors: Mitchell JA,Channell S,Hall G

    更新日期:1985-12-01 00:00:00

  • Context conditioning in habituation in the nematode Caenorhabditis elegans.

    abstract::Habituation has traditionally been considered a nonassociative form of learning. However, recent research suggests that retention of this nonassociative form of learning may be aided by associations formed during training. An example of this is context conditioning, in which animals that are trained and tested in the ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Rankin CH

    更新日期:2000-06-01 00:00:00

  • An association between granule cell density in the dentate gyrus and two-way avoidance conditioning in the house mouse.

    abstract::Mice with genetically associated variations in the number and density of granule cells in the dentate gyrus were tested for open-field activity, spatial maze learning, and two-way avoidance conditioning. The number of granule cells was not associated with any behavior measured. Only avoidance conditioning was related ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.6.844

    authors: Wimer C,Wimer RE,Wimer JS

    更新日期:1983-12-01 00:00:00

  • Dopaminergic activity modulation via aggression, status, and a visual social signal.

    abstract::Social interaction may elicit aggression, establish social rank, and be influenced by changes in central dopaminergic activity. In the lizard Anolis carolinensis, a sign stimulus (darkening of postorbital skin or eyespots) inhibits aggressive response from opponents, in part because it forms more rapidly in dominant m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.1.93

    authors: Korzan WJ,Forster GL,Watt MJ,Summers CH

    更新日期:2006-02-01 00:00:00

  • Impairing forgetting by preventing new learning and memory.

    abstract::Two causes of forgetting have been promulgated: memory trace decay and retroactive interference. The authors show that forgetting is an active process requiring both new learning and memory. In the present (1)Lymnaea model system, prevention of new learning of a conflicting association, inhibition of memory consolidat...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.3.787

    authors: Sangha S,Scheibenstock A,Martens K,Varshney N,Cooke R,Lukowiak K

    更新日期:2005-06-01 00:00:00

  • Repeated fluoxetine administration during adolescence stimulates aggressive behavior and alters serotonin and vasopressin neural development in hamsters.

    abstract::Fluoxetine is the only selective serotonin reuptake inhibitor registered for the treatment of major depressive disorder in pediatric populations, despite reports that it is disproportionately associated with an array of adverse side effects that include agitation, hostility, and overt acts of pathological aggression a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0029761

    authors: Ricci LA,Melloni RH Jr

    更新日期:2012-10-01 00:00:00

  • Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

    abstract::Norway rat pups were either handled (H) or undisturbed (nonhandled, NH) in the period between birth and weaning on Day 21. Following weaning, half of the animals in each group were housed socially (Soc), and half were housed in isolation (Isol). At 120-150 days of age, all animals were sacrificed, and the following re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.4.765

    authors: Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Tatarewicz JE,Sapolsky RM

    更新日期:1985-08-01 00:00:00