Abstract:
:Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral inactivity was increased by GR73632 injected into the caudodorsal PAG or the dorsal raphe. Flight behavior induced by stimulation of the dorsal PAG or by a footshock was decreased after injection of GR73632 into the dorsal PAG. Rats that had 6 pairings of a tone with a footshock after injection of GR73632 into the dorsal PAG displayed more freezing behavior than controls at the beginning of the session. However, there was no change in the shock- or the tone-induced freezing because some GR73632-treated rats, but no controls, froze during the baseline period. It is concluded that NK-1 receptors in the dorsal PAG modulate the unconditional but not the mnemonic aspects of fear behaviors.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Mongeau R,De Oca BM,Fanselow MS,Marsden CAdoi
10.1037//0735-7044.112.5.1125subject
Has Abstractpub_date
1998-10-01 00:00:00pages
1125-35issue
5eissn
0735-7044issn
1939-0084journal_volume
112pub_type
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