Anticipatory errors after unilateral lesions of the subthalamic nucleus in the rat: evidence for a failure of response inhibition.

Abstract:

:The nature of anticipatory responding in rats with unilateral subthalamic nucleus lesions was examined. Rats were trained to respond toward visual targets that were preceded by 1 of 4 different cues. For normal rats, a cue invokes an involuntary attentional orienting that enhances processing of the target at the location of attention. The cue is also a salient stimulus to which a response must be suppressed. Therefore, this task was used to investigate possible attentional impairments, as well as the ability of a lesioned rat to suppress competing motor programs. Responding under target control was not affected by the lesion. There was an increase in anticipatory responses before target onset, which could be accounted for by a failure to inhibit contralateral responses.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Phillips JM,Brown VJ

doi

10.1037//0735-7044.114.1.150

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

150-7

issue

1

eissn

0735-7044

issn

1939-0084

journal_volume

114

pub_type

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