Association of sleep parameters and memory in intact old rats and young rats with lesions in the nucleus basalis magnocellularis.

Abstract:

:Relations between sleep and memory were examined as a function of aging in rats. Sleep (24 hr), passive avoidance retention, and choline acetyltransferase (CAT) activity were assessed in 3 age-groups (6, 15, and 24 months old). Age-related alterations were evident in sleep, memory, and cortical and striatal CAT activity. Retention deficits in old rats were significantly correlated with several measures of paradoxical sleep. Similar analyses in 6- and 15-month-old rats with ibotenic acid-induced lesions of the nucleus basalis magnocellularis (NBM) showed several alterations in sleep, memory, and cortical CAT activity comparable to those seen in the old rats. One measure of paradoxical sleep, bout duration, correlated significantly with retention scores in rats with lesions. Thus, fragmented paradoxical sleep accompanies memory impairments in old rats and in young rats with NBM lesions.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Stone WS,Altman HJ,Berman RF,Caldwell DF,Kilbey MM

doi

10.1037//0735-7044.103.4.755

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

755-64

issue

4

eissn

0735-7044

issn

1939-0084

journal_volume

103

pub_type

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