Abstract:
:Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Kehoe P,Shoemaker WJ,Triano L,Callahan M,Rappolt Gdoi
10.1037//0735-7044.112.1.116subject
Has Abstractpub_date
1998-02-01 00:00:00pages
116-25issue
1eissn
0735-7044issn
1939-0084journal_volume
112pub_type
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