Adult rats stressed as neonates show exaggerated behavioral responses to both pharmacological and environmental challenges.

Abstract:

:Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Kehoe P,Shoemaker WJ,Triano L,Callahan M,Rappolt G

doi

10.1037//0735-7044.112.1.116

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

116-25

issue

1

eissn

0735-7044

issn

1939-0084

journal_volume

112

pub_type

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