Role of the hippocampus plus subjacent cortex but not amygdala in visuomotor conditional learning in rhesus monkeys.

Abstract:

:Rhesus monkeys were trained to learn a large series of visuomotor conditional associations, each involving the arbitrary coupling of a visual stimulus with 1 of 3 potentially correct forelimb movements. The monkeys then received bilateral aspiration lesions of either the amygdala plus subjacent cortex or the hippocampus plus subjacent cortex. Hippocampal but not amygdala removals significantly retarded the learning of new visuomotor associations. Neither lesion affected retention. The findings argue against a general role for the amygdala in associating information across modalities, construed broadly to include motor information. By contrast, the finding that the hippocampal formation and its subjacent cortex play a role in learning new sensorimotor associations supports the view that this region participates in the long-term storage of associative information or in the recall of recently acquired information.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Murray EA,Wise SP

doi

10.1037//0735-7044.110.6.1261

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1261-70

issue

6

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

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