Abstract:
:Two experiments examined the effects of infusing an N-methyl-D-aspartate (NMDA) receptor antagonist, d-2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Hatfield T,Gallagher Mdoi
10.1037//0735-7044.109.4.663subject
Has Abstractpub_date
1995-08-01 00:00:00pages
663-8issue
4eissn
0735-7044issn
1939-0084journal_volume
109pub_type
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