Taste-potentiated odor conditioning: impairment produced by infusion of an N-methyl-D-aspartate antagonist into basolateral amygdala.

Abstract:

:Two experiments examined the effects of infusing an N-methyl-D-aspartate (NMDA) receptor antagonist, d-2-amino-5-phosphonovalerate(d-APV), on taste-potentiated odor conditioning: a form of learning that is dependent on information processing in 2 sensory modalities. In Experiment 1, rats infused with d-APV were impaired in their acquisition of the potentiated learning to an odor cue. Expression of this learning and acquisition of a simple taste aversion remained intact following drug treatment. In Experiment 2, dose dependence and stereoselectivity were demonstrated for the antagonist compound. These results are consistent with previous studies demonstrating that either basolateral amygdala lesions, or treatment with NMDA antagonists, by other routes (systemic or intraventricular) produce selective deficits in taste-potentiated odor conditioning.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Hatfield T,Gallagher M

doi

10.1037//0735-7044.109.4.663

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

663-8

issue

4

eissn

0735-7044

issn

1939-0084

journal_volume

109

pub_type

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