Differential behavioral response to dopamine D2 agonists by sexually naive, sexually active, and sexually inactive male rats.

Abstract:

:This study was performed with male rats categorized as sexually naive (SN), sexually active (SA), or sexually inactive (SI). In a first experiment the effects of dopamine (DA) D2 agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA and SI rats were assessed. In a second experiment the DA D2 agonist B-HT 920 (0.2 mg/kg) was used, and examination was limited to SN and SA rats. The effects exerted on stretching-yawning, penile erection, and sedation by the same compounds at the same doses in these three rat categories were also investigated. The main findings were that SND 919 and B-HT 920 facilitated ejaculation in SA rats, and that the rats that were different as regards level of sexual activity exhibited different behavioral responses to the two DA agonists.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Giuliani D,Ferrari F

doi

10.1037//0735-7044.110.4.802

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

802-8

issue

4

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

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