Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach.

Abstract:

:Cost-benefit decision making is essential for organisms to adapt to their ever-changing environment. Most studies of cost-benefit decision making involve choice conditions in which effort and value are varied simultaneously. This prevents identification of the aspects of cost-benefit decision making that are affected by experimental manipulations. We developed operant assays to isolate the individual impacts of effort and value manipulations on cost-benefit decision making. In the concurrent effort choice (CEC) task, mice choose between exerting two distinct types of effort: the number of responses and the duration of a response, to earn the same reward. By parametrically varying response cost, psychometric functions are obtained that reflect how the two types of effort scale against one another. Direct manipulations of effort shift the functions. Because reward value is held constant in this task, differences in scaling of the two response types must be related to the effort manipulations. In the concurrent value choice (CVC) task, mice make the same type of response to earn rewards of different value (e.g., pellets vs. sucrose solutions). Here the effort required to earn one reward type is parametrically varied to obtain the psychometric function that scales the value of the two rewards into the number of responses subjects will pay to earn one reward over the other. Direct value manipulations shift these functions. We tested the effect of the dopamine D2 receptor antagonist, haloperidol, on performance in the CEC and CVC assays and found that D2R signaling is important for effort-based, but not value-based decision making. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Bailey MR,Chun E,Schipani E,Balsam PD,Simpson EH

doi

10.1037/bne0000361

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

101-118

issue

2

eissn

0735-7044

issn

1939-0084

pii

2020-19101-002

journal_volume

134

pub_type

杂志文章
  • Amiloride sensitivity in the neonatal rat.

    abstract::Amiloride-sensitive sodium channels in taste buds appear to play a key role in the response to NaCl stimulation, at least in adult rats. The researchers examined whether neonatal rats, which display an exaggerated preference for hypertonic NaCl solutions, lack functional amiloride-sensitive sodium channels. NaCl intak...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.5.981

    authors: Sollars SI,Bernstein IL

    更新日期:1994-10-01 00:00:00

  • An accessory sex gland aggression-promoting chemosignal in male mice.

    abstract::The present study investigated male murine accessory sex glands as potential sources of a urinary aggression-promoting chemosignal. Experiments 1-4 were designed to determine whether the removal of the following glands would eliminate voided urine chemosignal activity: vesicular and coagulating glands, Cowper's gland,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.5.777

    authors: Ingersoll DW,Morley KT,Benvenga M,Hands C

    更新日期:1986-10-01 00:00:00

  • Pattern of [14C]2-deoxyglucose concentration associated with potentiation of reproductive behavior by prostaglandin E2.

    abstract::One indication of receptive behavior of the female leopard frog, Rana pipiens, is absence of a release call during tactile stimulation of the trunk. Prostaglandin E2 (PGE2) inhibits this call. This experiment demonstrates a different pattern of [14C]2-deoxyglucose concentration in brains of 5 receptive females silence...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.5.1028

    authors: Diakow C,Woicyk W,McEachron DL,Adler NT

    更新日期:1989-10-01 00:00:00

  • Ultrasonic vocalization, laryngeal braking, and thermogenesis in rat pups: a reappraisal.

    abstract::In these experiments we tested the hypothesis that the respiratory events underlying rat pup ultrasonic vocalization (USV) facilitate brown adipose tissue (BAT) thermogenesis, as proposed by Blumberg and Alberts (1990). Laryngeal denervation or tracheostomy were used to reduce or eliminate laryngeal braking and preven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.2.354

    authors: Hofer MA,Shair HN

    更新日期:1993-04-01 00:00:00

  • Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons.

    abstract::Withdrawal from an escalating-dose, bingelike regimen of cocaine administration in rats produced significantly depressed levels of locomotor activity during the nocturnal portion of the day-night cycle. This effect was observed during the first 48 hr of testing. Extracellular single-unit recordings of ventral tegmenta...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.4.860

    authors: Koeltzow TE,White FJ

    更新日期:2003-08-01 00:00:00

  • Prenatal development of intrafetal and maternal-fetal synchrony.

    abstract::Fetal and maternal data were monitored serially at 6 gestational ages from 20 to 38 weeks in 195 Peruvian fetuses. Digitized data included fetal heart rate and motor activity, as well as maternal heart rate and electrodermal conductance. Time series analysis evaluated the development of synchrony in 2 streams of fetal...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.3.687

    authors: DiPietro JA,Caulfield LE,Irizarry RA,Chen P,Merialdi M,Zavaleta N

    更新日期:2006-06-01 00:00:00

  • Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.

    abstract::Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little examination of the influences that serotonin receptors may play in modula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016882

    authors: Pratt WE,Blackstone K,Connolly ME,Skelly MJ

    更新日期:2009-10-01 00:00:00

  • Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster).

    abstract::Male prairie voles (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP V1a receptor antagonist in the lateral se...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.4.910

    authors: Liu Y,Curtis JT,Wang Z

    更新日期:2001-08-01 00:00:00

  • Visual asymmetries in Japanese quail (Coturnix japonica) retain a lifelong potential for plasticity.

    abstract::Adult Japanese quail display left-eye/right-hemisphere dominance in visually guided sexual tracking. In 2 experiments, the authors set out to answer if this functional cerebral asymmetry is modifiable by posthatch monocular deprivation. In Experiment 1, the left or the right eye of 2-day old quail were closed for 70 d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016406

    authors: Gülbetekin E,Güntürkün O,Dural S,Cetinkaya H

    更新日期:2009-08-01 00:00:00

  • Analysis of learning deficits in aged rats on the W-track continuous spatial alternation task.

    abstract::Young and aged animals were tested on a spatial alternation task that consisted of two interleaved components: (1) an "outbound" or alternation component (working memory) and (2) an "inbound" component, requiring the animal to remember to return to a central location in space (spatial memory). In the present study, ag...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000269

    authors: Kapellusch AJ,Lester AW,Schwartz BA,Smith AC,Barnes CA

    更新日期:2018-12-01 00:00:00

  • Long-term study of chronic oral aluminum exposure and spatial working memory in rats.

    abstract::The authors report an effort to advance animal models that mimic the cognitive decline of Alzheimer's disease. Rats were trained and repeatedly tested in a spatial delayed matching-to-position paradigm in the water maze, with the location of the submerged platform changing between, but not within, days. After Trial 1 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.2.351

    authors: von Linstow Roloff E,Platt B,Riedel G

    更新日期:2002-04-01 00:00:00

  • Prenatal binge ethanol exposure on gestation days 19-20, but not on days 17-18, increases postnatal ethanol acceptance in rats.

    abstract::Previous research shows that prenatal binge ethanol exposure during gestation days (GD) 17 to 20 of the rat, increases postnatal ethanol intake and enhances ethanol's palatability, both effects being mediated by the opioid system. The amniotic fluid of the last period of gestation (GD 20) of the rat has been found to ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0019482

    authors: Díaz-Cenzano E,Chotro MG

    更新日期:2010-06-01 00:00:00

  • The role of perirhinal cortex in visual discrimination learning for visual secondary reinforcement in rats.

    abstract::Perirhinal cortex in monkeys has been thought to be involved in visual associative learning. The authors examined rats' ability to make associations between visual stimuli in a visual secondary reinforcement task. Rats learned 2-choice visual discriminations for secondary visual reinforcement. They showed significant ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.6.1318

    authors: Eacott MJ,Norman G,Gaffan EA

    更新日期:2003-12-01 00:00:00

  • Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.

    abstract::Previous studies on drug abuse have shown that response to drug-associated cues exist during prolonged abstinence. In succession to previous investigations in our laboratory on morphine dependence and our research on acquisition and expression phases of morphine-conditioned place preference (CPP), in this study we att...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000336

    authors: Namvar P,Zarrabian S,Nazari-Serenjeh F,Sadeghzadeh F,Haghparast A

    更新日期:2019-12-01 00:00:00

  • Quantitative analysis of the relation between gill amplitude and siphon duration in the defensive withdrawal reflex of Aplysia.

    abstract::The defensive withdrawal reflex of the mantle organs (gill, siphon, and mantle shelf) of the marine mollusc Aplysia californica has been the subject of numerous studies investigating the cellular and molecular mechanisms of learning. In behavioral experiments, the reflex has been monitored by means of two different re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.2.292

    authors: Stopfer M,Carew TJ

    更新日期:1987-04-01 00:00:00

  • Influence of opioid peptides on learning and memory processes in the chick.

    abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.2.429

    authors: Patterson TA,Schulteis G,Alvarado MC,Martinez JL Jr,Bennett EL,Rosenzweig MR,Hruby VJ

    更新日期:1989-04-01 00:00:00

  • Cognitive gender differences in very young children parallel biologically based cognitive gender differences in monkeys.

    abstract::Infant humans were trained on 2 cognitive tests that have previously revealed, in infant monkeys, a double dissociation that was reversible by perinatal manipulations of androgens and ablations of specific brain sites. Children showed the same sex-linked behavior found with infant monkeys: young boys were superior on ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.4.673

    authors: Overman WH,Bachevalier J,Schuhmann E,Ryan P

    更新日期:1996-08-01 00:00:00

  • Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits.

    abstract::Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairings to early acquisition (consolidation) or well trained (over...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.5.935

    authors: Akase E,Alkon DL,Disterhoft JF

    更新日期:1989-10-01 00:00:00

  • Morphine influences on classical aversive conditioned heart rate in rats.

    abstract::The present series of three experiments was concerned with the effects of morphine and the morphine antagonist naloxone on the development of a classical aversive heart rate (HR) conditioned response (CR) to a tone conditioned stimulus (CS) paired with an electric shock unconditioned stimulus (US). In the first study,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.2.244

    authors: Mahalik T,Fitzgerald RD

    更新日期:1988-04-01 00:00:00

  • Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

    abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016328

    authors: Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

    更新日期:2009-08-01 00:00:00

  • Receptive field plasticity in the auditory cortex during frequency discrimination training: selective retuning independent of task difficulty.

    abstract::Classical conditioning is known to induce frequency-specific receptive field (RF) plasticity in the auditory cortex (ACx). This study determined the effects of discrimination training on RFs at two levels of task difficulty. Single unit and cluster discharges were recorded in the ACx of adult guinea pigs trained in a ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.1.82

    authors: Edeline JM,Weinberger NM

    更新日期:1993-02-01 00:00:00

  • Cognitive impairment in rats fed high-fat diets: a specific effect of saturated fatty-acid intake.

    abstract::One-month-old rats were fed 1 of 4 high-fat diets (20% fat) or chow (4.5% fat) for 3 months. Dietary saturated (SFA), monounsaturated (MUFA), or polyunsaturated (PUFA) fatty acids varied such that their independent effects on cognitive performance could be tested. Rats were tested on a variable-interval delayed-altern...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.3.451

    authors: Greenwood CE,Winocur G

    更新日期:1996-06-01 00:00:00

  • Nonlinear temporal integration of brain stimulation reward.

    abstract::A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, altho...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026180

    authors: Hawkins RD

    更新日期:2011-12-01 00:00:00

  • CS-US preexposure effects on trace eyeblink conditioning in young rats: potential implications for functional brain development.

    abstract::Recent studies of delay eyeblink conditioning (EBC) in young rats have demonstrated different effects of various conditioned and unconditioned stimulus (CS-US) preexposure conditions on learning at different ages. The present study extends this research to trace EBC. Subjects experienced 1 of 3 preexposure conditions ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.2.257

    authors: Claflin DI,Buffington ML

    更新日期:2006-04-01 00:00:00

  • Pelvic and pudendal nerves influence the display of paced mating behavior in response to estrogen and progesterone in the female rat.

    abstract::Two experiments examined whether the pudendal and pelvic autonomic nerves are important for pacing behavior shown by the female rat during mating. Ovariectomized female rats received bilateral transection of the pudendal (Pux), pelvic (Pex), or pudendal and pelvic (Pu + Pex) nerves or were sham-operated (Shx). Lordoti...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.4.690

    authors: Erskine MS

    更新日期:1992-08-01 00:00:00

  • Microlesions of the ventromedial nucleus of the hypothalamus: effects on sociosexual behaviors in male rats.

    abstract::Electrolytic microlesions aimed at the dorsomedial portion of the ventromedial nucleus (VMN) of the hypothalamus were generated, and effects on copulation, 50-kHz vocalizations, scent marking, and sexual motivation were measured. Male rats were tested before and after lesions, after castration, and after testosterone ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.5.1227

    authors: Harding SM,McGinnis MY

    更新日期:2005-10-01 00:00:00

  • Effects of parturition and maternal experience on noradrenaline and acetylcholine release in the olfactory bulb of sheep.

    abstract::Acetylcholine (ACh) and noradrenaline (NA) release in the olfactory bulb (OB) of ewes was monitored using microdialysis. Both ACh and NA release increased at parturition in multiparous but not in primiparous ewes. However, vaginocervical stimulation performed 6 hr postpartum induced an increase of ACh and NA release i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.4.662

    authors: Lévy F,Guevara-Guzman R,Hinton MR,Kendrick KM,Keverne EB

    更新日期:1993-08-01 00:00:00

  • Phantom auditory sensation in rats: an animal model for tinnitus.

    abstract::In order to measure tinnitus induced by sodium salicylate injections, 84 pigmented rats, distributed among 14 groups in five experiments, were used in a conditioned suppression paradigm. In Experiment 1, all groups were trained with a conditioned stimulus (CS) consisting of the offset of a continuous background noise....

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.6.811

    authors: Jastreboff PJ,Brennan JF,Coleman JK,Sasaki CT

    更新日期:1988-12-01 00:00:00

  • Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD).

    abstract::Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.6.1475

    authors: Szechtman H,Sulis W,Eilam D

    更新日期:1998-12-01 00:00:00

  • Modification of a weak learning experience by memory retrieval in the day-old chick.

    abstract::Activation of memory retrieval after weak learning (WL), during either the short- or intermediate-term stages of memory in day-old chickens, resulted in the strengthening of the memory to levels normally associated with strong learning. Administration of the calcium channel antagonist lanthanum chloride, the glutamate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.114.4.713

    authors: Summers MJ,Crowe SF,Ng KT

    更新日期:2000-08-01 00:00:00