CS-US preexposure effects on trace eyeblink conditioning in young rats: potential implications for functional brain development.

Abstract:

:Recent studies of delay eyeblink conditioning (EBC) in young rats have demonstrated different effects of various conditioned and unconditioned stimulus (CS-US) preexposure conditions on learning at different ages. The present study extends this research to trace EBC. Subjects experienced 1 of 3 preexposure conditions (paired CS-US, unpaired CS-US, or no stimuli) at either 20 or 24 days of age. Four days later, they were conditioned using either trace (Experiment 1) or delay (Experiment 2) EBC parameters. Results were similar at both ages tested. Paired preexposure facilitated acquisition of delay but not trace relative to context preexposure. Unpaired preexposure impaired acquisition of both delay and trace. These behavioral findings provide a foundation for hypotheses about the functional maturation of cerebellar, hippocampal, and entorhinal learning circuits.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Claflin DI,Buffington ML

doi

10.1037/0735-7044.120.2.257

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

257-66

issue

2

eissn

0735-7044

issn

1939-0084

pii

2006-05348-004

journal_volume

120

pub_type

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