Abstract:
:Recent studies of delay eyeblink conditioning (EBC) in young rats have demonstrated different effects of various conditioned and unconditioned stimulus (CS-US) preexposure conditions on learning at different ages. The present study extends this research to trace EBC. Subjects experienced 1 of 3 preexposure conditions (paired CS-US, unpaired CS-US, or no stimuli) at either 20 or 24 days of age. Four days later, they were conditioned using either trace (Experiment 1) or delay (Experiment 2) EBC parameters. Results were similar at both ages tested. Paired preexposure facilitated acquisition of delay but not trace relative to context preexposure. Unpaired preexposure impaired acquisition of both delay and trace. These behavioral findings provide a foundation for hypotheses about the functional maturation of cerebellar, hippocampal, and entorhinal learning circuits.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Claflin DI,Buffington MLdoi
10.1037/0735-7044.120.2.257subject
Has Abstractpub_date
2006-04-01 00:00:00pages
257-66issue
2eissn
0735-7044issn
1939-0084pii
2006-05348-004journal_volume
120pub_type
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