Neonatal hind-paw injury disrupts acquisition of an instrumental response in adult spinal rats.

Abstract:

:The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only on PD 5. Subjects receiving a unilateral neonatal hind-paw injury showed decreased mechanical threshold (hyperalgesia) on the previously injured hind paw throughout development. This decrease in threshold survived spinal transection (at T2) at 12 weeks of age. Injured subjects also showed significant impairment in a spinal instrumental learning task performed by the previously injured hind paw. This disruption of learning indicates a disruption of spinal plasticity that may be due to induction of long-term changes in nociceptive processing within the spinal cord.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Young EE,Baumbauer KM,Elliot A,Joynes RL

doi

10.1037/0735-7044.121.5.1095

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1095-100

issue

5

eissn

0735-7044

issn

1939-0084

pii

2007-13974-027

journal_volume

121

pub_type

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