Behavioral sensitization to cocaine, but not cocaine-conditioned behavior, is associated with increased dopamine occupation of its receptors in the nucleus accumbens.

Abstract:

:Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. Only the paired group exhibiting context-specific behavioral sensitization had more dopamine bound to both D1-like and D2-like receptors in the nucleus accumbens than did rats in the control group receiving cocaine on the test day. No effects on receptor occupation were found in rats showing a classical conditioned response to a context previously paired with cocaine. Thus, sensitization to cocaine, but not classical conditioning of cocaine's behavioral effects, was associated with greater dopaminergic neurotransmission selectively in the nucleus accumbens.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Burechailo L,Martin-Iverson MT

doi

10.1037//0735-7044.110.6.1388

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1388-96

issue

6

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

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