17beta-estradiol modifies stress-induced and age-related changes in hippocampal synaptic plasticity.


:The female steroid hormone 17beta-estradiol enhances synaptic transmission and the magnitude of longterm potentiation (LTP) in adult rodent hippocampal slices. Long-term depression (LTD), another form of synaptic plasticity, occurs more prominently in hippocampal slices from aged rodents. A decrease in LTP has been recorded in hippocampal slices from adult rodents behaviorally stressed just before tissue preparation and electrophysiological recording. Here, the authors test the hypothesis that estrogen modifies synaptic plasticity in both adult and aged rodents, whether behaviorally stressed or not. Our results indicate that estrogen enhances LTP and attenuates LTD, thus producing a protective effect against both aging and stress. These results also provide new approaches that can be used to reverse age and stress-related learning and memory dysfunction.


Behav Neurosci


Behavioral neuroscience


Foy MR,Baudry M,Foy JG,Thompson RF




Has Abstract


2008-04-01 00:00:00














  • Facilitation of fear extinction by midbrain periaqueductal gray infusions of RB101(S), an inhibitor of enkephalin-degrading enzymes.

    abstract::Mu-opioid receptors in the ventrolateral quadrant midbrain periaqueductal gray (vIPAG) contribute to extinction of conditioned fear. The present experiment studied whether fear extinction could be facilitated by infusions of a peptidase inhibitor that reduces catabolism of vIPAG enkephalins. Rats were trained to fear ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: McNally GP

    更新日期:2005-12-01 00:00:00

  • Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice.

    abstract::Previous research emphasized the impact of traumatic brain injury on cholinergic systems and associated cognitive functions. Here we addressed the converse question: Because of the available evidence indicating cognitive and neuronal vulnerabilities in humans expressing low-capacity cholinergic systems or with declini...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Koshy Cherian A,Tronson NC,Parikh V,Kucinski A,Blakely RD,Sarter M

    更新日期:2019-08-01 00:00:00

  • Central administration of cocaine produces age-dependent effects on behavior in the fetal rat.

    abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Simonik DK,Robinson SR,Smotherman WP

    更新日期:1994-12-01 00:00:00

  • Involvement of serotonin and oxytocin in neural mechanism regulating amicable social signal in male mice: Implication for impaired recognition of amicable cues in BALB/c strain.

    abstract::Social signals play a primary role in regulating social relationships among male mice. The present series of experiments investigated the neural mechanisms underlying an induction of amicable cues that facilitate social approach in male mice of the C57BL/6 (B6) and BALB/c (BALB) strains. Male mice exhibit approach beh...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Arakawa H

    更新日期:2017-04-01 00:00:00

  • Differential behavioral response to dopamine D2 agonists by sexually naive, sexually active, and sexually inactive male rats.

    abstract::This study was performed with male rats categorized as sexually naive (SN), sexually active (SA), or sexually inactive (SI). In a first experiment the effects of dopamine (DA) D2 agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA and SI rats were assessed. In a second experiment the DA D2 ago...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Giuliani D,Ferrari F

    更新日期:1996-08-01 00:00:00

  • Effects of naltrexone and signaling inescapable electric shock on nociception and gastric lesions in rats.

    abstract::The antinociceptive effects of signaled shock and its physiological underpinnings were examined in two experiments. In Experiment 1, rats were exposed to one of three shock conditions: no shock, unsignaled shock, and signaled (by a 10-s, 1000-Hz tone) shock. In each condition the rats were tested hourly in the absence...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Guile MN,McCutcheon NB

    更新日期:1984-08-01 00:00:00

  • Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.

    abstract::The striatum is implicated in response selection and performance, the dorsal striatum in sensorimotor control and habit learning, and the ventral striatum in motivation and rewarded behaviors. Ventral striatal lesions produce performance changes on food-reinforced, progressive-ratio (PR) schedules, but the effects of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Eagle DM,Humby T,Dunnett SB,Robbins TW

    更新日期:1999-08-01 00:00:00

  • Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.

    abstract::This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intrac...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Takahashi LK,Kalin NH,Baker EW

    更新日期:1990-04-01 00:00:00

  • Opioids and attachment in rhesus macaque (Macaca mulatta) abusive mothers.

    abstract::This study investigated the role of the endogenous opioid system in maternal and affiliative behavior of group-living rhesus macaque (Macaca mulatta) mothers with a history of abusive parenting. Eighteen mothers received an injection of the opioid antagonist naltrexone or saline for 5 days per week for the first 4 wee...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Graves FC,Wallen K,Maestripieri D

    更新日期:2002-06-01 00:00:00

  • Consequences of serial cortical, hippocampal, and thalamic lesions and of different lengths of overtraining on the acquisition and retention of learning tasks.

    abstract::The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Markowitsch HJ,Kessler J,Streicher M

    更新日期:1985-04-01 00:00:00

  • Hippocampal lesions impair contextual fear conditioning in two strains of mice.

    abstract::Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioni...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Chen C,Kim JJ,Thompson RF,Tonegawa S

    更新日期:1996-10-01 00:00:00

  • Mnemonic theories of hippocampal function.

    abstract::Although mnemonic interpretations of hippocampal function in people have been readily accepted for many years, similar interpretations of hippocampal function in animals have received a number of challenges. This article reviews two of these challenges, shows how they were resolved in favor of some kind of mnemonic in...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Olton DS,Wible CG,Shapiro ML

    更新日期:1986-12-01 00:00:00

  • Prefrontal cortex and rule abstraction: where and whether? Theoretical comment on Moore et al. (2009).

    abstract::The primate dorsolateral prefrontal cortex is implicated in diverse aspects of behavioral regulation, cognitive control, and memory. However, direct neuropsychological evidence supporting a requirement of this area in functions other than spatial working memory has been scarce. T. L. Moore, S. P. Schettler, R. J. Kill...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Baxter MG

    更新日期:2009-04-01 00:00:00

  • Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats.

    abstract::The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Steidl S,Li L,Yeomans JS

    更新日期:2001-06-01 00:00:00

  • Specificity of the cardiac response to conspecific vocalization in chimpanzees.

    abstract::Heart rate measures were used to examine the functional response of young chimpanzees and orangutans to acoustic stimuli, including white noise and chimpanzee vocalizations (threat, stress, and alarm). The initial response of the animals to all stimuli was characterized by a prominent cardiac deceleration and an incre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Berntson GG,Boysen ST

    更新日期:1989-04-01 00:00:00

  • Bilateral nature of the conditioned eyeblink response in the rabbit: behavioral characteristics and potential mechanisms.

    abstract::In Pavlovian eyeblink conditioning, the conditioned response (CR) is highly lateralized to the eye to which the unconditioned stimulus (US) has been directed. However, the initial conditioning of one eye can facilitate subsequent conditioning of the other eye, a phenomenon known as the intereye transfer (IET) effect. ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lee T,Kim JJ,Wagner AR

    更新日期:2008-12-01 00:00:00

  • Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine.

    abstract::Large neocortical injuries can interfere with the initial performance of many previously learned behaviors. This dysfunction, however, may not be attributable to the loss of the memories of learned behaviors but to a failure to access memories that are spared. The results of this experiment support this hypothesis by ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: LeVere TE,Brugler T,Sandin M,Gray-Silva S

    更新日期:1989-06-01 00:00:00

  • Neural cell adhesion molecules, learning, and memory in the domestic chick.

    abstract::The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. The results reported here demonstrate that neural cell adhesion molecules (NCAMs) play a time-dependent role in this recognition memory. Dark-reared chicks were train...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Solomonia RO,McCabe BJ,Horn G

    更新日期:1998-06-01 00:00:00

  • Selective effects of triazolam on memory for emotional, relative to neutral, stimuli: differential effects on gist versus detail.

    abstract::Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Buchanan TW,Karafin MS,Adolphs R

    更新日期:2003-06-01 00:00:00

  • Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat.

    abstract::Previous research conducted in monkeys and rats has established that the perirhinal cortex is critically involved in object- or stimulus-recognition memory, whereas other research suggests this region may contribute to memory for object discriminations. These findings do not rule out the possibility that the perirhina...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wiig KA,Burwell RD

    更新日期:1998-08-01 00:00:00

  • Dissociations between appetitive and consummatory responses by pharmacological manipulations of reward-relevant brain regions.

    abstract::Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Ikemoto S,Panksepp J

    更新日期:1996-04-01 00:00:00

  • Postischemic hyperactivity in the Mongolian gerbil correlates with loss of hippocampal neurons.

    abstract::Gerbils show a postischemic increase in locomotor activity that correlates to the extent of neuron loss in the hippocampal CA1 subfield. It has been suggested that this hyperactivity is predictive of neuron loss in the CA1. In this study the correlation between postischemic hyperactivity and neuron loss in several hip...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Andersen MB,Zimmer J,Sams-Dodd F

    更新日期:1997-12-01 00:00:00

  • Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia.

    abstract::The catechol-O-methyltransferase (COMT) val158met polymorphism has received attention in schizophrenia due to its role in prefrontal dopamine catabolism. Given the rich dopaminergic innervations of the olfactory bulb and the influence of dopamine on the transmission of olfactory signals, the authors examined the influ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kamath V,Moberg PJ,Gur RE,Doty RL,Turetsky BI

    更新日期:2012-02-01 00:00:00

  • Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice.

    abstract::Neuromuscular impairment by ethanol likely involves complex effects on balance, gait, muscle strength, and other features of motor coordination. The present experiments showed that relative sensitivity to ethanol-induced motor impairment in serotonin 1B (5-HT(1B)) null mutant and control mice was task dependent. We fo...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Boehm SL 2nd,Schafer GL,Phillips TJ,Browman KE,Crabbe JC

    更新日期:2000-04-01 00:00:00

  • Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus).

    abstract::The authors measured the effects of centrally infused peptides on social approach behaviors in goldfish (Carassius auratus), a social teleost. Vasotocin (VT) inhibited approach responses toward the visual stimuli of conspecifics in the absence of aggressive or sexual olfactory contextual cues in males, and a V1 recept...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Thompson RR,Walton JC

    更新日期:2004-06-01 00:00:00

  • Increases in vocalization and motor reflex thresholds are influenced by the site of morphine microinjection: comparisons following administration into the periaqueductal gray, ventral medulla, and spinal subarachnoid space.

    abstract::The relative influence of morphine microinjected into the periaqueductal gray, ventral medulla (nucleus raphé magnus or nucleus reticularis gigantocellularis), or spinal subarachnoid space on the thresholds of responses organized at spinal (spinal motor reflexes, SMRs), medullary (vocalizations elicited during shock, ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Borszcz GS

    更新日期:1995-06-01 00:00:00

  • Time-based prospective memory impairment in patients with thalamic stroke.

    abstract::The role of the thalamus in memory is potentially very complex. However, most studies on the memory impairments of thalamic lesions have focused on retrospective memory, rarely on prospective memory. To explore the effect of thalamic lesions on event-based prospective memory (EBPM) and time-based prospective memory (T...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Cheng H,Tian Y,Hu P,Wang J,Wang K

    更新日期:2010-02-01 00:00:00

  • Species differences in the vasopressin-immunoreactive pathways in the bed nucleus of the stria terminalis and medial amygdaloid nucleus in prairie voles (Microtus ochrogaster) and meadow voles (Microtus pennsylvanicus).

    abstract::Vasopressin-immunoreactive (AVP-ir) cells in the bed nucleus of the stria terminalis (BST) and medial amygdaloid nucleus (MA) and their AVP-ir projections to the lateral septum were studied in monogamous prairie voles (Microtus ochrogaster) and promiscuous meadow voles (M. pennsylvanicus). A sexually dimorphic AVP-ir ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wang Z

    更新日期:1995-04-01 00:00:00

  • Selective immunotoxic lesions of basal forebrain cholinergic neurons: twenty years of research and new directions.

    abstract::The advent of the selective cholinergic toxin, 192 IgG-saporin, dramatically shaped subsequent research on the role of the basal forebrain in learning and memory. In particular, several articles (including the authors' 1995 Behavioral Neuroscience paper; M. G. Baxter, D. J. Bucci, L. K., Gorman, R. G. Wiley, & M. Gall...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Baxter MG,Bucci DJ

    更新日期:2013-10-01 00:00:00

  • Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

    abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

    更新日期:2009-08-01 00:00:00