Anterograde amnesia induced by hyperthermia in rats.

Abstract:

:Anterograde amnesia (AA), forgetting of events that occur following a traumatic episode, has recently been demonstrated by using a mild decrease in temperature (hypothermia) as the amnestic agent. However, no data currently exist to indicate if an increase in body temperature (hyperthermia) might affect memory processing in a similar manner. Experiments 1 and 2 demonstrated that increasing the colonic body temperature of the rat to 3-4 degrees C or more above normal during avoidance training produced a significant retention loss when the test occurred 24 hr after training. Slight hyperthermia to 1-2 degrees C above normal did not impair retention. In Experiment 3, AA resulting from an elevation in temperature was reversed by reheating "amnestic" subjects just prior to the 24-hr test. By rapidly reversing hyperthermia immediately after the training trial with a cooling procedure, Experiment 4 demonstrated that hyperthermia-induced AA was not the result of retrograde influences of the heating treatment. Implications of these results are discussed in terms of possible retention deficits which could conceivably follow environmental heat stress or fever hyperthermia resulting from bacterial infection.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Ahlers ST,Riccio DC

doi

10.1037//0735-7044.101.3.333

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

333-40

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

101

pub_type

杂志文章
  • The role of the medial prefrontal cortex in the play fighting of rats.

    abstract::Although decorticated rats are able to engage in play, their play is abnormal in three ways. First, decorticates do not display the normal, age-related shifts in defensive strategies during development. Second, decorticates do not modify their defensive tactics in response to the social identity of their partners. Thi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0017617

    authors: Bell HC,McCaffrey DR,Forgie ML,Kolb B,Pellis SM

    更新日期:2009-12-01 00:00:00

  • Central administration of cocaine produces age-dependent effects on behavior in the fetal rat.

    abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.6.1179

    authors: Simonik DK,Robinson SR,Smotherman WP

    更新日期:1994-12-01 00:00:00

  • Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

    abstract::Norway rat pups were either handled (H) or undisturbed (nonhandled, NH) in the period between birth and weaning on Day 21. Following weaning, half of the animals in each group were housed socially (Soc), and half were housed in isolation (Isol). At 120-150 days of age, all animals were sacrificed, and the following re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.99.4.765

    authors: Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Tatarewicz JE,Sapolsky RM

    更新日期:1985-08-01 00:00:00

  • 17beta-estradiol modifies stress-induced and age-related changes in hippocampal synaptic plasticity.

    abstract::The female steroid hormone 17beta-estradiol enhances synaptic transmission and the magnitude of longterm potentiation (LTP) in adult rodent hippocampal slices. Long-term depression (LTD), another form of synaptic plasticity, occurs more prominently in hippocampal slices from aged rodents. A decrease in LTP has been re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.2.301

    authors: Foy MR,Baudry M,Foy JG,Thompson RF

    更新日期:2008-04-01 00:00:00

  • Fat substitutes promote weight gain in rats consuming high-fat diets.

    abstract::The use of food products designed to mimic the sensory properties of sweet and fat while providing fewer calories has been promoted as a method for reducing food intake and body weight. However, such products may interfere with a learned relationship between the sensory properties of food and the caloric consequences ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0024404

    authors: Swithers SE,Ogden SB,Davidson TL

    更新日期:2011-08-01 00:00:00

  • Pedunculopontine tegmental nucleus lesions impair stimulus--reward learning in autoshaping and conditioned reinforcement paradigms.

    abstract::The role of the pedunculopontine tegmental nucleus (PPTg) in stimulus-reward learning was assessed by testing the effects of PPTg lesions on performance in visual autoshaping and conditioned reinforcement (CRf) paradigms. Rats with PPTg lesions were unable to learn an association between a conditioned stimulus (CS) an...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.114.2.285

    authors: Inglis WL,Olmstead MC,Robbins TW

    更新日期:2000-04-01 00:00:00

  • Attenuation of cycloheximide-induced amnesia in mice with strychnine sulfate.

    abstract::Two experiments were conducted to determine the effectiveness of strychnine sulfate in attenuating the amnesia induced in mice by small doses of cycloheximide (CYC). Previously, reversal of CYC-induced amnesia catecholamine agonists has been taken as evidence that protein synthesis inhibitors induce amnesia via an inh...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.2.323

    authors: Leccese AP,Quinton EE

    更新日期:1983-04-01 00:00:00

  • Chronic lithium chloride infusions: conditioned suppression of food intake and preference.

    abstract::A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acqu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.2.290

    authors: Bernstein IL,Goehler LE

    更新日期:1983-04-01 00:00:00

  • Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats.

    abstract::The influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and perforant path LTP were assessed in pentobarbital-anesthetized rats. Water deprivation did not affect baseline cell excitabi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.1.44

    authors: Maren S,DeCola JP,Swain RA,Fanselow MS,Thompson RF

    更新日期:1994-02-01 00:00:00

  • Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice.

    abstract::Previous research emphasized the impact of traumatic brain injury on cholinergic systems and associated cognitive functions. Here we addressed the converse question: Because of the available evidence indicating cognitive and neuronal vulnerabilities in humans expressing low-capacity cholinergic systems or with declini...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000310

    authors: Koshy Cherian A,Tronson NC,Parikh V,Kucinski A,Blakely RD,Sarter M

    更新日期:2019-08-01 00:00:00

  • Enhancement of excessive lever-pressing after post-training signal attenuation in rats by repeated administration of the D1 antagonist SCH 23390 or the D2 agonist quinpirole, but not the D1 agonist SKF 38393 or the D2 antagonist haloperidol.

    abstract::The authors have recently shown that attenuation of an external response feedback leads to excessive lever-pressing that is not associated with attempts to collect reward, and they have suggested that this may be an analogue to "unreasonable" excessive behavior characteristic of obsessive-compulsive disorder. The pres...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.6.1291

    authors: Joel D,Avisar A,Doljansky J

    更新日期:2001-12-01 00:00:00

  • Amygdala inactivation blocks expression of conditioned memory modulation and the promotion of avoidance and freezing.

    abstract::Rats were exposed to shock-paired cues immediately after training on an appetitive preference task. Elevated levels of freezing in and active avoidance of the shock-paired compartment were observed, and memory for the appetitive task was improved when tested 24 hr later. Intra-amygdala muscimol injected before the pos...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.1.24

    authors: Holahan MR,White NM

    更新日期:2004-02-01 00:00:00

  • Microlesions of the ventromedial nucleus of the hypothalamus: effects on sociosexual behaviors in male rats.

    abstract::Electrolytic microlesions aimed at the dorsomedial portion of the ventromedial nucleus (VMN) of the hypothalamus were generated, and effects on copulation, 50-kHz vocalizations, scent marking, and sexual motivation were measured. Male rats were tested before and after lesions, after castration, and after testosterone ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.5.1227

    authors: Harding SM,McGinnis MY

    更新日期:2005-10-01 00:00:00

  • Postischemic hyperactivity in the Mongolian gerbil correlates with loss of hippocampal neurons.

    abstract::Gerbils show a postischemic increase in locomotor activity that correlates to the extent of neuron loss in the hippocampal CA1 subfield. It has been suggested that this hyperactivity is predictive of neuron loss in the CA1. In this study the correlation between postischemic hyperactivity and neuron loss in several hip...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.6.1205

    authors: Andersen MB,Zimmer J,Sams-Dodd F

    更新日期:1997-12-01 00:00:00

  • Effects of excitotoxic lesions of the central amygdaloid nucleus on the potentiation of reward-related stimuli by intra-accumbens amphetamine.

    abstract::The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 microg/microl). Rats were trained to associate a light-plus-noise ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.5.981

    authors: Robledo P,Robbins TW,Everitt BJ

    更新日期:1996-10-01 00:00:00

  • Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity.

    abstract::Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to noc...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.6.1418

    authors: Crown ED,Grau JW,Meagher MW

    更新日期:2004-12-01 00:00:00

  • Female túngara frogs do not experience the continuity illusion.

    abstract::In humans and some nonhuman vertebrates, a sound containing brief silent gaps can be rendered perceptually continuous by inserting noise into the gaps. This so-called "continuity illusion" arises from a phenomenon known as "auditory induction" and results in the perception of complete auditory objects despite fragment...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000115

    authors: Baugh AT,Ryan MJ,Bernal XE,Rand AS,Bee MA

    更新日期:2016-02-01 00:00:00

  • Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.

    abstract::Among young adults, 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is a popular drug of abuse, and anecdotal evidence indicates that repeated use of MDMA may result in impairments in sexual function and decreased sex drive in human users. There has been little investigation of the effects of MDMA on sexual functi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.3.586

    authors: Straiko MM,Gudelsky GA,Coolen LM

    更新日期:2007-06-01 00:00:00

  • Abnormal topography and altered acquisition of conditioned eyeblink responses in a rodent model of attention-deficit/hyperactivity disorder.

    abstract::The spontaneously hypertensive rat (SHR) has been suggested as a possible animal model of attention-deficit/hyperactivity disorder (ADHD). Reductions in the volume of the cerebellum and impairments in cerebellar-dependent eyeblink conditioning have been observed in ADHD, prompting investigation into whether SHRs also ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.1.63

    authors: Chess AC,Green JT

    更新日期:2008-02-01 00:00:00

  • Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

    abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016328

    authors: Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

    更新日期:2009-08-01 00:00:00

  • Different neural responses to stranger and personally familiar faces in shy and bold adults.

    abstract::The shy-bold continuum is a fundamental behavioral trait conserved across human and nonhuman animals. Individual differences along the shy-bold continuum are presumed to arise from, and are maintained by, differences in the excitability of forebrain limbic areas involved in the evaluation of stimulus saliency. To test...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.3.704

    authors: Beaton EA,Schmidt LA,Schulkin J,Antony MM,Swinson RP,Hall GB

    更新日期:2008-06-01 00:00:00

  • The midbrain periaqueductal gray and fear extinction: opioid receptor subtype and roles of cyclic AMP, protein kinase A, and mitogen-activated protein kinase.

    abstract::Four experiments studied the opioid receptor subtype and signal transduction mechanisms mediating fear extinction in the ventrolateral quadrant of the midbrain periaqueductal gray (vlPAG). Microinjection of a mu- but not a delta- or kappa-opioid receptor antagonist into the vlPAG retarded extinction. Extinction was al...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.4.1023

    authors: McNally GP,Lee BW,Chiem JY,Choi EA

    更新日期:2005-08-01 00:00:00

  • CS-US preexposure effects on trace eyeblink conditioning in young rats: potential implications for functional brain development.

    abstract::Recent studies of delay eyeblink conditioning (EBC) in young rats have demonstrated different effects of various conditioned and unconditioned stimulus (CS-US) preexposure conditions on learning at different ages. The present study extends this research to trace EBC. Subjects experienced 1 of 3 preexposure conditions ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.2.257

    authors: Claflin DI,Buffington ML

    更新日期:2006-04-01 00:00:00

  • Sex versus sweet: opposite effects of opioid drugs on the reward of sucrose and sexual pheromones.

    abstract::Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.2.416

    authors: Agustín-Pavón C,Martínez-Ricós J,Martínez-García F,Lanuza E

    更新日期:2008-04-01 00:00:00

  • Fixation of spinal reflex alterations in spinal rats by sensory nerve stimulation.

    abstract::Two preparations in which sensory nerve stimulation was used to obtain peripherally induced spinal fixation in spinal rats are described. In the first preparation, proportionally greater amounts of persisting poststimulation flexor muscle contraction, as measured by a force displacement transducer, were produced as st...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/h0092460

    authors: Steinmetz JE,Patterson MM

    更新日期:1985-02-01 00:00:00

  • Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.

    abstract::Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta-agonist, isoproterenol, or the alpha1-agonist, phen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.115.1.165

    authors: Berridge CW,O'Neill J

    更新日期:2001-02-01 00:00:00

  • Dietary self-selection in intact, ovariectomized, and estradiol-treated female rats.

    abstract::The effects of estrogenic stimulation on diet selection were examined in intact, estrous cycling rats, ovariectomized (OVX) rats, and OVX rats given estradiol benzoate (EB) hormone replacement therapy. In Experiment 1, OVX was associated with the nearly exclusive choice of the more calorically dense diet of a pair of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.1.125

    authors: Bartness TJ,Waldbillig RJ

    更新日期:1984-02-01 00:00:00

  • The ontogeny of human learning in delay, long-delay, and trace eyeblink conditioning.

    abstract::The ontogeny of associative learning in delay (750-ms conditional stimulus [CS], 650-ms interstimulus interval [ISI]), long-delay (1,350-ms CS, 1,250-ms ISI), and trace (750-ms CS, 500-ms trace interval, 1,250-ms ISI) eyeblink conditioning was examined in 5-month-old human infants and adults. Infants and adults showed...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1037/0735-7044.117.6.1196

    authors: Herbert JS,Eckerman CO,Stanton ME

    更新日期:2003-12-01 00:00:00

  • Shock-induced hyperalgesia: II. Role of the dorsolateral periaqueductal gray.

    abstract::Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explore...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.3.539

    authors: McLemore S,Crown ED,Meagher MW,Grau JW

    更新日期:1999-06-01 00:00:00

  • Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.

    abstract::The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mount...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.3.439

    authors: Packard MG,McGaugh JL

    更新日期:1992-06-01 00:00:00