Abstract:
:Two experiments were conducted to determine the effectiveness of strychnine sulfate in attenuating the amnesia induced in mice by small doses of cycloheximide (CYC). Previously, reversal of CYC-induced amnesia catecholamine agonists has been taken as evidence that protein synthesis inhibitors induce amnesia via an inhibition of catecholamine synthesis. The results of Experiment 1 suggested that strychnine sulfate could attenuate an amnesia induced by 30 mg/kg CYC, and the results of Experiment 2 revealed that even the robust amnesia induced by 75 mg/kg CYC could be attenuated by strychnine sulfate. The results of these experiments support the results of previous experiments which showed that agents having little or no effect on the catecholamines can nonetheless attenuate amnesia induced by the protein synthesis inhibitors. Thus, some method other than attenuation of the retention deficit by catecholamine agonists must be used to test the hypothesis that protein synthesis inhibitors induce amnesia via an inhibition of catecholamine synthesis.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Leccese AP,Quinton EEdoi
10.1037//0735-7044.97.2.323subject
Has Abstractpub_date
1983-04-01 00:00:00pages
323-6issue
2eissn
0735-7044issn
1939-0084journal_volume
97pub_type
杂志文章abstract::Multi-unit recording of siphon nerve activity in intact Aplysia california with chronically implanted cuff electrodes provided a monitor of activity in a central pattern generator, the Interneuron II (Int II) network, which produces large siphon and gill contractions both spontaneously and after tactile stimulation of...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.98.4.609
更新日期:1984-08-01 00:00:00
abstract::Similar to elderly humans, aged Long-Evans rats exhibit individual differences in performance on tasks that critically depend on the medial temporal lobe memory system. Although reduced memory performance is common, close to half of aged rats in this outbred rodent population perform within the range of young subjects...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000332
更新日期:2019-10-01 00:00:00
abstract::In these experiments we tested the hypothesis that the respiratory events underlying rat pup ultrasonic vocalization (USV) facilitate brown adipose tissue (BAT) thermogenesis, as proposed by Blumberg and Alberts (1990). Laryngeal denervation or tracheostomy were used to reduce or eliminate laryngeal braking and preven...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.2.354
更新日期:1993-04-01 00:00:00
abstract::Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether thi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0029699
更新日期:2012-10-01 00:00:00
abstract::Available evidence indicates that common genes influence alcohol and tobacco abuse in humans. The studies reported here used mouse models to evaluate the hypothesis that genetically determined variability in the alpha4beta2* nicotinic receptor modulates genetically determined variability in the intake of both nicotine...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.1.26
更新日期:2005-02-01 00:00:00
abstract::Effects of the ingestion of protein and carbohydrate conditioned a preference for one size of chow particle over another, which was triggered by need for a specific nutrient. This learned elicitation of nutrient-specific dietary selection was not changed by injection of dl-fenfluramine HCl (2.5 mg/kg). This indicates ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::In different experiments, pairings of a drug (pentobarbital or morphine) or place as the conditioned stimulus (CS) with lithium-induced sickness as the unconditioned stimulus (US) were given to rats to produce Pavlovian conditioning. Control rats received unpaired exposures. In the test, each rat was exposed to the CS...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.1.106
更新日期:1992-02-01 00:00:00
abstract::Classical conditioning is known to induce frequency-specific receptive field (RF) plasticity in the auditory cortex (ACx). This study determined the effects of discrimination training on RFs at two levels of task difficulty. Single unit and cluster discharges were recorded in the ACx of adult guinea pigs trained in a ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.1.82
更新日期:1993-02-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.111.5.1123
更新日期:1997-10-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.99.3.436
更新日期:1985-06-01 00:00:00
abstract::Young and aged animals were tested on a spatial alternation task that consisted of two interleaved components: (1) an "outbound" or alternation component (working memory) and (2) an "inbound" component, requiring the animal to remember to return to a central location in space (spatial memory). In the present study, ag...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000269
更新日期:2018-12-01 00:00:00
abstract::Microstructural analysis of licking behavior in the rat was conducted (a) to describe in detail the characteristics of benzodiazepine-induced changes in ingestion and (b) to determine if the changes are consistent with an alteration in palatability. The effects of the benzodiazepine receptor (BZR) agonist midazolam (0...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.2.447
更新日期:1998-04-01 00:00:00
abstract::The gustatory rejection response of the cabbage looper, Trichoplusia ni (Lepidoptera: Noctuidae), habituates to antifeedant compounds, allowing for the consumption of deterrent yet nontoxic plant materials. In the present study, we demonstrate that habituation to an antifeedant compound (quinine) persists through the ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0020741
更新日期:2010-10-01 00:00:00
abstract::Four experiments studied the opioid receptor subtype and signal transduction mechanisms mediating fear extinction in the ventrolateral quadrant of the midbrain periaqueductal gray (vlPAG). Microinjection of a mu- but not a delta- or kappa-opioid receptor antagonist into the vlPAG retarded extinction. Extinction was al...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.4.1023
更新日期:2005-08-01 00:00:00
abstract::Personality is known to influence cognitive and affective functioning as well as the risk of psychiatric disorders. Exploration of the neurobiological correlates of personality traits has the potential to enhance understanding of their significance in development of related psychopathological states. The authors exami...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.121.4.643
更新日期:2007-08-01 00:00:00
abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0026461
更新日期:2012-02-01 00:00:00
abstract::The immature gustatory system of the neonatal rat is characterized by sensitivity to disruption by early interventions such as receptor or nerve damage. The present studies examined the effect of chorda tympani transection (neoCTX) of neonates on adult preference for salt and nonsalt stimuli. NeoCTX at 10 days of age ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.3.551
更新日期:1996-06-01 00:00:00
abstract::This study assessed the activity of head direction (HD) cells during performance of a spatial reference memory task on a radial arm maze. Rats were trained to select a maze arm located in a constant position in relation to a salient extramaze visual landmark. HD cell discharge properties remained relatively stable acr...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.111.1.3
更新日期:1997-02-01 00:00:00
abstract::This study investigated the role of the endogenous opioid system in maternal and affiliative behavior of group-living rhesus macaque (Macaca mulatta) mothers with a history of abusive parenting. Eighteen mothers received an injection of the opioid antagonist naltrexone or saline for 5 days per week for the first 4 wee...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.116.3.489
更新日期:2002-06-01 00:00:00
abstract::Bilateral ibotenic acid lesions of the lateral, but not the medial, parabrachial nucleus (PBN) blocked conditioned taste aversion (CTA) induced by morphine but not conditioned place preference induced by morphine. The same lateral PBN lesions also blocked conditioned place aversion produced by low intraperitoneal dose...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.107.1.147
更新日期:1993-02-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.4.730
更新日期:2004-08-01 00:00:00
abstract::Neuromuscular impairment by ethanol likely involves complex effects on balance, gait, muscle strength, and other features of motor coordination. The present experiments showed that relative sensitivity to ethanol-induced motor impairment in serotonin 1B (5-HT(1B)) null mutant and control mice was task dependent. We fo...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::The ontogeny of associative learning in delay (750-ms conditional stimulus [CS], 650-ms interstimulus interval [ISI]), long-delay (1,350-ms CS, 1,250-ms ISI), and trace (750-ms CS, 500-ms trace interval, 1,250-ms ISI) eyeblink conditioning was examined in 5-month-old human infants and adults. Infants and adults showed...
journal_title:Behavioral neuroscience
pub_type: 临床试验,杂志文章
doi:10.1037/0735-7044.117.6.1196
更新日期:2003-12-01 00:00:00
abstract::The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. The results reported here demonstrate that neural cell adhesion molecules (NCAMs) play a time-dependent role in this recognition memory. Dark-reared chicks were train...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.3.646
更新日期:1998-06-01 00:00:00
abstract::The estradiol (E2), estrogen receptor-α (ERα), testosterone (T), and androgen receptor (AR) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. Here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000094
更新日期:2015-12-01 00:00:00
abstract::Methylphenidate (MPD) is widely prescribed for attention-deficit/hyperactivity disorder in the United States. Patients, mostly school-age children, are taking the drug orally. To simulate the human condition, the authors used a cracker to administer methylphenidate orally (without the stress of handling) from Postnata...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.121.6.1272
更新日期:2007-12-01 00:00:00
abstract::The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 microg/microl). Rats were trained to associate a light-plus-noise ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.5.981
更新日期:1996-10-01 00:00:00
abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.108.6.1179
更新日期:1994-12-01 00:00:00
abstract::Nondemented Parkinson's disease (PD) patients report problems on nonmotor tasks that depend on visual or visuospatial abilities. In PD, foveal vision is impaired. Experimental studies in humans and monkeys established that foveal processing and visuospatial attention may be linked through saccadic eye movements. Sacca...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.1037/a0031225
更新日期:2013-04-01 00:00:00
abstract::Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.100.4.483
更新日期:1986-08-01 00:00:00