The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of morphine.

Abstract:

:Bilateral ibotenic acid lesions of the lateral, but not the medial, parabrachial nucleus (PBN) blocked conditioned taste aversion (CTA) induced by morphine but not conditioned place preference induced by morphine. The same lateral PBN lesions also blocked conditioned place aversion produced by low intraperitoneal doses of morphine (shown to produce aversion, instead of preference, due to a restricted action on gut opiate receptors). Lateral PBN lesions did not block CTA produced by LiCl. Cerebral peduncle lesions that destroyed the direct descending projections from the visceral cortex to the PBN did not block CTA induced by morphine, nor did ibotenic acid lesions of the tegmental pedunculopontine nuclei (shown to block place preference produced by even high morphine doses). It is suggested that the lateral PBN is a critical link in the neural pathway carrying the aversive motivational effects of opiates from the gut into the central nervous system, independent of the neural pathway carrying the rewarding motivational effects of morphine.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Bechara A,Martin GM,Pridgar A,van der Kooy D

doi

10.1037//0735-7044.107.1.147

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

147-60

issue

1

eissn

0735-7044

issn

1939-0084

journal_volume

107

pub_type

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