Delayed development of place navigation compared to directional responding in young rats.

Abstract:

:Recent work from our laboratory demonstrates that both young and adult rats show a preference for directional responding over place navigation in the Morris water task. Based on these findings, previous studies on the postnatal development of spatial learning have most likely assessed the ontogeny of directional responding instead of true place navigation. Here, we examined the development of directional responding and place navigation among young male and female rats using two variants of the Morris water task that specifically require directional and place responses. In the place variant, the hidden platform remained in the same absolute spatial location regardless of pool position. In the direction variant, the platform remained in the same direction in the room regardless of pool position. We found that ability to solve the direction task emerged around 20 to 21 days of age, whereas ability to solve the place task did not emerge until 26 to 27 days of age. These findings indicate that directional responding and place navigation exhibit different developmental trajectories and suggest that the 2 forms of navigation have different neurobiological bases.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Akers KG,Candelaria-Cook FT,Rice JP,Johnson TE,Hamilton DA

doi

10.1037/a0014594

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

267-75

issue

2

eissn

0735-7044

issn

1939-0084

pii

2009-04037-005

journal_volume

123

pub_type

杂志文章
  • Reversible lesions of the nucleus of the solitary tract attenuate the memory-modulating effects of posttraining epinephrine.

    abstract::Rats implanted with cannula tips placed above the nucleus of the solitary tract (NTS) were trained to obtain food pellets placed in 2 arms of a Y maze and then given a footshock in 1 arm of the maze. The rats then received bilateral injections of lidocaine or buffer into the NTS and peripheral injections of saline or ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Williams CL,McGaugh JL

    更新日期:1993-12-01 00:00:00

  • Behavioral thermoregulation, core temperature, and motor activity: simultaneous quantitative assessment in rats after dopamine and prostaglandin E1.

    abstract::These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.5.858

    authors: Marques PR,Spencer RL,Burks TF,McDougal JN

    更新日期:1984-10-01 00:00:00

  • Amphetamine-induced sensitization and reward uncertainty similarly enhance incentive salience for conditioned cues.

    abstract::Amphetamine and stress can sensitize mesolimbic dopamine-related systems. In Pavlovian autoshaping, repeated exposure to uncertainty of reward prediction can enhance motivated sign-tracking or attraction to a discrete reward-predicting cue (lever-conditioned stimulus; CS+), as well as produce cross-sensitization to am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000064

    authors: Robinson MJ,Anselme P,Suchomel K,Berridge KC

    更新日期:2015-08-01 00:00:00

  • Behavioral spectral sensitivities of different retinal areas in pigeons.

    abstract::The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.1.170

    authors: Remy M,Emmerton J

    更新日期:1989-02-01 00:00:00

  • Medial prefrontal lesions impair performance in an operant delayed nonmatch to sample working memory task.

    abstract::Cognitive functions, such as working memory, are disrupted in most psychiatric disorders. Many of these processes are believed to depend on the medial prefrontal cortex (mPFC). Traditionally, maze-based behavioral tasks, which have a strong exploratory component, have been used to study the role of the mPFC in working...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000357

    authors: Benoit LJ,Holt ES,Teboul E,Taliaferro JP,Kellendonk C,Canetta S

    更新日期:2020-06-01 00:00:00

  • Contingency learning and causal detection in Hermissenda: I. Behavior.

    abstract::The addition of extra light-alone or rotation-alone presentations to sequences of light-rotation pairings reduced the associative suppression of phototaxic behavior for the nudibranch Hermissenda. Training-induced changes in Type B photoreceptor light responses were found to parallel the training-induced behavioral ch...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.1.13

    authors: Farley J

    更新日期:1987-02-01 00:00:00

  • Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task.

    abstract::Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993). The results presented here provide evidence in humans supporting these hypo...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.1.223

    authors: Atri A,Sherman S,Norman KA,Kirchhoff BA,Nicolas MM,Greicius MD,Cramer SC,Breiter HC,Hasselmo ME,Stern CE

    更新日期:2004-02-01 00:00:00

  • Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats.

    abstract::The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Steidl S,Li L,Yeomans JS

    更新日期:2001-06-01 00:00:00

  • Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity.

    abstract::Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to noc...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.6.1418

    authors: Crown ED,Grau JW,Meagher MW

    更新日期:2004-12-01 00:00:00

  • Drug discrimination training during chronic drug treatment affects the development of tolerance.

    abstract::The purpose of this experiment was to evaluate the extent to which continued drug discrimination training during chronic drug treatment affects the development of tolerance. Rats were trained to discriminate distilled water from 0.75 mg/kg amphetamine in a two-lever drug discrimination task. Two groups were then given...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.2.373

    authors: Caul WF,Burgin KL,Barrett RJ

    更新日期:1989-04-01 00:00:00

  • The effects of long-term ovariectomy and estrogen replacement therapy on learning and memory in monkeys (Macaca fascicularis).

    abstract::This study determined the effects of estrogen loss and replacement therapy on learning and memory function in monkeys (Macaca fascicularis). The ability to learn, remember, and perform reversals of object discriminations and the accuracy on a spatial delayed response task were found to be comparable in young adult sur...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Voytko ML

    更新日期:2000-12-01 00:00:00

  • Dissociation between peripheral and central heat loss mechanisms induced by neonatal capsaicin.

    abstract::Fifty-eight 4-day-old male rats were studied. Peripheral desensitization was induced in 36 rats by sc administration of capsaicin in increasing doses (350, 700, 1,400, 2,100, and 2,800 micrograms) on 5 consecutive days. When adult, 9 treated and 5 control rats were chronically implanted with a lateral intracerebrovent...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.5.822

    authors: Dib B

    更新日期:1983-10-01 00:00:00

  • Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia.

    abstract::Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.5.873

    authors: McGlinchey-Berroth R,Carrillo MC,Gabrieli JD,Brawn CM,Disterhoft JF

    更新日期:1997-10-01 00:00:00

  • Selective effects of the delta-opioid receptor agonist DPDPE on consummatory successive negative contrast.

    abstract::Two experiments explored the role of the opioid system in a situation involving a surprising reduction in reward magnitude: consummatory successive negative contrast. Rats received access to 32% sucrose solution (preshift Trials 1-10) followed by 4% solution (postshift Trials 11-15). Independent groups received an inj...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.2.446

    authors: Wood M,Daniel AM,Papini MR

    更新日期:2005-04-01 00:00:00

  • Operant conditioning of hippocampal theta: dissociating reward from performance deficits.

    abstract::Dopaminergic blocking agents have been known to suppress intracranial self-stimulation, but whether the suppression results from a reduction in the rewarding value of stimulation or from motor deficits has remained controversial. We have resolved this controversy by developing an operant technique minimally dependent ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.5.626

    authors: Fantie BD,Nakajima S

    更新日期:1987-10-01 00:00:00

  • Ultrasonic vocalization, laryngeal braking, and thermogenesis in rat pups: a reappraisal.

    abstract::In these experiments we tested the hypothesis that the respiratory events underlying rat pup ultrasonic vocalization (USV) facilitate brown adipose tissue (BAT) thermogenesis, as proposed by Blumberg and Alberts (1990). Laryngeal denervation or tracheostomy were used to reduce or eliminate laryngeal braking and preven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.2.354

    authors: Hofer MA,Shair HN

    更新日期:1993-04-01 00:00:00

  • Developmental exposure to methimazole increases anxiety behavior in zebrafish.

    abstract::The role of thyroid hormones in vertebrate development has been well documented for several decades. As hypothyroidism during critical periods of development can cause defects to the development of every major organ system, including brain, eye, and general morphology, we hypothesized that hypothyroidism would affect ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000087

    authors: Reider M,Connaughton VP

    更新日期:2015-10-01 00:00:00

  • The "proactive" model of learning: Integrative framework for model-free and model-based reinforcement learning utilizing the associative learning-based proactive brain concept.

    abstract::Reinforcement learning (RL) is a powerful concept underlying forms of associative learning governed by the use of a scalar reward signal, with learning taking place if expectations are violated. RL may be assessed using model-based and model-free approaches. Model-based reinforcement learning involves the amygdala, th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000116

    authors: Zsuga J,Biro K,Papp C,Tajti G,Gesztelyi R

    更新日期:2016-02-01 00:00:00

  • Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.

    abstract::The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.5.1006

    authors: Rhodes JS,van Praag H,Jeffrey S,Girard I,Mitchell GS,Garland T Jr,Gage FH

    更新日期:2003-10-01 00:00:00

  • Reactivation of hippocampal ensemble activity patterns in the aging rat.

    abstract::In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Gerrard JL,Kudrimoti H,McNaughton BL,Barnes CA

    更新日期:2001-12-01 00:00:00

  • Environmental enrichment as a therapy for autism: A clinical trial replication and extension.

    abstract::Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/bne0000068

    authors: Woo CC,Donnelly JH,Steinberg-Epstein R,Leon M

    更新日期:2015-08-01 00:00:00

  • Association of an odor with activation of olfactory bulb noradrenergic beta-receptors or locus coeruleus stimulation is sufficient to produce learned approach responses to that odor in neonatal rats.

    abstract::These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenergic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-recepto...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.114.5.957

    authors: Sullivan RM,Stackenwalt G,Nasr F,Lemon C,Wilson DA

    更新日期:2000-10-01 00:00:00

  • Implications of temporal variation in maternal care for the prediction of neurobiological and behavioral outcomes in offspring.

    abstract::Previous studies in Long-Evans rats demonstrated a significant relationship between variation in pup licking/grooming and arched-back nursing (LG-ABN) and offspring development. However, maternal care is dynamic and exhibits significant temporal variation. In the current study, we assessed temporal variation in LG and...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0031219

    authors: Jensen Peña C,Champagne FA

    更新日期:2013-02-01 00:00:00

  • Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

    abstract::PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-behavioral deficits and whether these deficits occur before or after a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.5.982

    authors: Dodart JC,Meziane H,Mathis C,Bales KR,Paul SM,Ungerer A

    更新日期:1999-10-01 00:00:00

  • A small amount of wheel running facilitates eating in nondeprived rats.

    abstract::A high level of dopaminergic activation such as that produced by a high dose of amphetamine suppresses eating, whereas a low level such as that produced by a low dose can have the opposite effect. Like a high dose of amphetamine, a high level of wheel running also suppresses eating. It was hypothesized that this suppr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.6.1492

    authors: Lett BT,Grant VL,Gaborko LL

    更新日期:1996-12-01 00:00:00

  • Fimbria-fornix transections disrupt the ontogeny of delayed alternation but not position discrimination in the rat.

    abstract::In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the P...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.3.386

    authors: Freeman JH Jr,Stanton ME

    更新日期:1991-06-01 00:00:00

  • Pelvic and pudendal nerves influence the display of paced mating behavior in response to estrogen and progesterone in the female rat.

    abstract::Two experiments examined whether the pudendal and pelvic autonomic nerves are important for pacing behavior shown by the female rat during mating. Ovariectomized female rats received bilateral transection of the pudendal (Pux), pelvic (Pex), or pudendal and pelvic (Pu + Pex) nerves or were sham-operated (Shx). Lordoti...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.4.690

    authors: Erskine MS

    更新日期:1992-08-01 00:00:00

  • DREADDS: Use and application in behavioral neuroscience.

    abstract::Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such transformative tool in behavioral neuroscience research, chemogenetics (or Designer Receptors Exclusively Activated by Designer Drugs, DREADDS). As transformative tec...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037/bne0000135

    authors: Smith KS,Bucci DJ,Luikart BW,Mahler SV

    更新日期:2016-04-01 00:00:00

  • Transient inactivation of the thalamic nucleus reuniens and rhomboid nucleus produces deficits of a working-memory dependent tactile-visual conditional discrimination task.

    abstract::Working memory depends on communication between the hippocampus and the prefrontal cortex (PFC); however, the neural circuitry that mediates interactions between these brain areas has not been well characterized. Two candidate structures are the thalamic reuniens (RE) and rhomboid (Rh) nuclei, which are reciprocally c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0034653

    authors: Hallock HL,Wang A,Shaw CL,Griffin AL

    更新日期:2013-12-01 00:00:00

  • Effects of hydrocortisone on false memory recognition in healthy men and women.

    abstract::Most of the studies focusing on the effect of stress on false memories by using psychosocial and physiological stressors yielded diverse results. In the present study, we systematically tested the effect of exogenous hydrocortisone using a false memory paradigm. In this placebo-controlled study, 37 healthy men and 38 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000170

    authors: Duesenberg M,Weber J,Schaeuffele C,Fleischer J,Hellmann-Regen J,Roepke S,Moritz S,Otte C,Wingenfeld K

    更新日期:2016-12-01 00:00:00