Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task.

Abstract:

:Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993). The results presented here provide evidence in humans supporting these hypotheses. Young healthy subjects first learned baseline word pairs (A-B) and, after a delay, learned additional overlapping (A-C) and nonoverlapping (D-E) word pairs. As predicted, when compared with subjects who received the active placebo glycopyrrolate (4 microg/kg) and subjects who were not injected, those who received scopolamine (8 microg/kg) showed (a) overall impairment in new word paired-associate learning, but no impairment in cued recall of previously learned associates; and (b) greater impairment in learning overlapping (A-C) compared with nonoverlapping (D-E) paired associates.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Atri A,Sherman S,Norman KA,Kirchhoff BA,Nicolas MM,Greicius MD,Cramer SC,Breiter HC,Hasselmo ME,Stern CE

doi

10.1037/0735-7044.118.1.223

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

223-36

issue

1

eissn

0735-7044

issn

1939-0084

pii

2004-10963-023

journal_volume

118

pub_type

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