Thyroxine treatment reduces the anorectic effect of estradiol in rats.

Abstract:

:In order to examine a possible interaction between thyroxine and estradiol in the control of feeding, 14 ovariectomized adult female rats were given daily injections of 9.8 micrograms/100 g of body weight of 1-thyroxine (T). Another 14 rats received 0.15 ml of saline (S) subcutaneously each day, and food intake was measured for both groups daily. After 15 days of treatment, 8 rats from each group were also given a single injection of 6 micrograms of estradiol benzoate (EB), and the remaining 6 rats of each group received peanut oil vehicle. It was found that T-treated rats showed a significantly smaller drop in food intake after EB than did S-treated rats. This thyroxine-induced decrease in responsiveness to EB did not appear due to any changes in body weight per se but may be related to effects of thyroxine on general metabolism.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Young JK

doi

10.1037//0735-7044.100.2.284

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

284-7

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

100

pub_type

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