Response-reinforcer associations after caudate-putamen lesions in the rat: spatial discrimination and overshadowing-potentiation effects in instrumental learning.

Abstract:

:Experiment 1 demonstrated that rats with caudate-putamen lesions show an impairment in the acquisition and reversal of a spatial maze task when compared with unoperated control subjects. Experiment 2 examined lever-press responding supported by a variable interval schedule in three groups of subjects: a group with caudate-putamen lesions, a group with lesions of the posterior cortex, and an unoperated control group. The presentation of a 0.5-s, response-contingent light correlated with reinforcement generated an elevated response rate in the two operated groups but tended to suppress responding in the control group, perhaps by overshadowing the response-reinforcer relation. Only the group with cortical lesions maintained the elevated rate when the light was uncorrelated with food delivery. Experiment 3 confirmed for these same subjects that caudate-putamen lesions produce a spatial learning deficit. No deficit was seen in the posterior cortex group. It is suggested that caudate-putamen lesions disrupt the mechanism underlying the response-reinforcer association upon which spatial maze learning and free operant responding in part depend.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Mitchell JA,Channell S,Hall G

doi

10.1037//0735-7044.99.6.1074

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

1074-88

issue

6

eissn

0735-7044

issn

1939-0084

journal_volume

99

pub_type

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