Abstract:
:Experiment 1 demonstrated that rats with caudate-putamen lesions show an impairment in the acquisition and reversal of a spatial maze task when compared with unoperated control subjects. Experiment 2 examined lever-press responding supported by a variable interval schedule in three groups of subjects: a group with caudate-putamen lesions, a group with lesions of the posterior cortex, and an unoperated control group. The presentation of a 0.5-s, response-contingent light correlated with reinforcement generated an elevated response rate in the two operated groups but tended to suppress responding in the control group, perhaps by overshadowing the response-reinforcer relation. Only the group with cortical lesions maintained the elevated rate when the light was uncorrelated with food delivery. Experiment 3 confirmed for these same subjects that caudate-putamen lesions produce a spatial learning deficit. No deficit was seen in the posterior cortex group. It is suggested that caudate-putamen lesions disrupt the mechanism underlying the response-reinforcer association upon which spatial maze learning and free operant responding in part depend.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Mitchell JA,Channell S,Hall Gdoi
10.1037//0735-7044.99.6.1074subject
Has Abstractpub_date
1985-12-01 00:00:00pages
1074-88issue
6eissn
0735-7044issn
1939-0084journal_volume
99pub_type
杂志文章abstract::The primate dorsolateral prefrontal cortex is implicated in diverse aspects of behavioral regulation, cognitive control, and memory. However, direct neuropsychological evidence supporting a requirement of this area in functions other than spatial working memory has been scarce. T. L. Moore, S. P. Schettler, R. J. Kill...
journal_title:Behavioral neuroscience
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更新日期:2011-08-01 00:00:00
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更新日期:1997-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1037/a0013511
更新日期:2008-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.1.117
更新日期:1996-02-01 00:00:00
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更新日期:2011-04-01 00:00:00
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doi:10.1037/a0016487
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1037/bne0000271
更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1037/bne0000064
更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1037//0735-7044.98.6.1094
更新日期:1984-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
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