Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning.

Abstract:

:This study examined the role of the amygdala in mediating the effects of glucocorticoids on spatial memory in rats. Adrenalectomy (ADX) induced 4-5 days prior to training impaired memory in a water-maze spatial task. This effect was reversed by a posttraining injection of dexamethasone (0.3 mg/kg sc) but not by corticosterone (0.3 mg/kg). Lesions of the basolateral (BLA), but not the central (CEA) or the medial (MEA), amygdala blocked the effects of ADX and dexamethasone. ADX also impaired acquisition. CEA, MEA, and BLA lesions blocked the ADX effect on acquisition. In adrenally intact rats, intracerebroventricular posttraining injections of a specific glucocorticoid receptor (GR or Type-II) antagonist impaired retention, and BLA lesions blocked the effect of the GR antagonist. These findings provide evidence that the BLA is involved in mediating glucocorticoid influences on learning and memory.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Roozendaal B,Portillo-Marquez G,McGaugh JL

doi

10.1037//0735-7044.110.5.1074

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1074-83

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

110

pub_type

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