Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans.

Abstract:

:The effects of various doses (40 microg/kg/hr, 300 microg/kg/hr, 600 microg/kg/hr or placebo) of hydrocortisone on tasks assessing working and declarative memory function were measured in 4 groups of 10 young men. During the infusion, participants were given an item-recognition working memory task, a paired-associate declarative memory task, and a continuous performance task used to control possible concomitant effects of corticosteroids on vigilance. The results revealed significant acute effects of the highest dose of hydrocortisone on working memory function, without any significant effect on declarative memory function or arousal-vigilance performance. These results suggest that working memory is more sensitive than declarative memory to the acute elevations of corticosteroids, which could explain the detrimental effects of corticosteroids on acquisition and consolidation of information, as reported in the literature.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Lupien SJ,Gillin CJ,Hauger RL

doi

10.1037//0735-7044.113.3.420

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

420-30

issue

3

eissn

0735-7044

issn

1939-0084

journal_volume

113

pub_type

临床试验,杂志文章,随机对照试验
  • Are individual differences in fatigue vulnerability related to baseline differences in cortical activation?

    abstract::Recent evidence suggests that underlying patterns of cortical activation may partially account for individual differences in susceptibility to the effects of sleep deprivation. Here, functional magnetic resonance imaging (fMRI) was used to examine the activation of military pilots whose sleep-deprivation vulnerability...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.3.694

    authors: Caldwell JA,Mu Q,Smith JK,Mishory A,Caldwell JL,Peters G,Brown DL,George MS

    更新日期:2005-06-01 00:00:00

  • Cognitive impairment in rats fed high-fat diets: a specific effect of saturated fatty-acid intake.

    abstract::One-month-old rats were fed 1 of 4 high-fat diets (20% fat) or chow (4.5% fat) for 3 months. Dietary saturated (SFA), monounsaturated (MUFA), or polyunsaturated (PUFA) fatty acids varied such that their independent effects on cognitive performance could be tested. Rats were tested on a variable-interval delayed-altern...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.3.451

    authors: Greenwood CE,Winocur G

    更新日期:1996-06-01 00:00:00

  • Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.

    abstract::Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta-agonist, isoproterenol, or the alpha1-agonist, phen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.115.1.165

    authors: Berridge CW,O'Neill J

    更新日期:2001-02-01 00:00:00

  • Postnatal choline supplementation in preweanling mice: sexually dimorphic behavioral and neurochemical effects.

    abstract::The aim of this study was to investigate the effects of postnatal choline supplementation on neurochemical and behavioral parameters in preweanling BALB/cByJ mice. Mouse pups were injected daily subcutaneously with choline chloride (0.85 mM/g body weight) from Postnatal Day (PND) 1 to PND 16. Pups performed a passive ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Ricceri L,Berger-Sweeney J

    更新日期:1998-12-01 00:00:00

  • The relation of feeding and activity following septal lesions in rats.

    abstract::The patterns of intake of liquid diet and water were recorded in diet-deprived rats with septal lesions and neurologically intact controls during the first hour of diet access. The occurrences of grooming, resting/sleeping, and exploring were also recorded. Both groups of rats consumed similar amounts of diet in one m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.3.416

    authors: Flynn FW,Evey LA,Steele TL,Mitchell JC

    更新日期:1986-06-01 00:00:00

  • Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape.

    abstract::Exercise can reduce symptoms of depression and anxiety in humans, but therapeutic effects of exercise in an animal model of stress-related mood disorders have yet to be demonstrated. In the current study, the authors investigated the ability of wheel running to reverse a long-lasting interference with shuttle box esca...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.5.992

    authors: Greenwood BN,Strong PV,Dorey AA,Fleshner M

    更新日期:2007-10-01 00:00:00

  • Sustained attention in the mouse: a study of the relationship with the cerebellum.

    abstract::To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.2.477

    authors: Martin LA,Goldowitz D,Mittleman G

    更新日期:2006-04-01 00:00:00

  • Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits.

    abstract::Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairings to early acquisition (consolidation) or well trained (over...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.5.935

    authors: Akase E,Alkon DL,Disterhoft JF

    更新日期:1989-10-01 00:00:00

  • The role of hippocampal regions CA3 and CA1 in matching entorhinal input with retrieval of associations between objects and context: theoretical comment on Lee et al. (2005).

    abstract::Models of hippocampal function have proposed different functions for hippocampal regions CA3 and CA1, commonly proposing that CA1 performs a match-mismatch comparison of memory retrieval with sensory input. The study by I. Lee, M. R. Hunsaker, and R. P. Kesner (2005) tested these models using selective lesions of hipp...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/0735-7044.119.1.342

    authors: Hasselmo ME

    更新日期:2005-02-01 00:00:00

  • Neuroethological studies of reflex plasticity in intact Aplysia.

    abstract::Multi-unit recording of siphon nerve activity in intact Aplysia california with chronically implanted cuff electrodes provided a monitor of activity in a central pattern generator, the Interneuron II (Int II) network, which produces large siphon and gill contractions both spontaneously and after tactile stimulation of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.4.609

    authors: Eberly LB,Pinsker HM

    更新日期:1984-08-01 00:00:00

  • Attenuation of cycloheximide-induced amnesia in mice with strychnine sulfate.

    abstract::Two experiments were conducted to determine the effectiveness of strychnine sulfate in attenuating the amnesia induced in mice by small doses of cycloheximide (CYC). Previously, reversal of CYC-induced amnesia catecholamine agonists has been taken as evidence that protein synthesis inhibitors induce amnesia via an inh...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.97.2.323

    authors: Leccese AP,Quinton EE

    更新日期:1983-04-01 00:00:00

  • Attentional effects of lesions to the anterior cingulate cortex: how prior reinforcement influences distractibility.

    abstract::Morphological changes in the anterior cingulate cortex are found in subjects with schizophrenia, attention deficit hyperactivity disorder, and obsessive-compulsive disorder. These changes are hypothesized to underlie the impairments these individuals show on tasks that require cognitive control. The anterior cingulate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0023250

    authors: Newman LA,McGaughy J

    更新日期:2011-06-01 00:00:00

  • Central administration of cocaine produces age-dependent effects on behavior in the fetal rat.

    abstract::Rat fetuses were exposed to cocaine, lidocaine, or saline on Gestational Day 20 or 21 to provide information about cocaine effects on behavior during prenatal development. Cocaine was administered into the cisterna magna of individual fetal subjects to restrict effects to the CNS. Behavioral effects of cocaine were co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.6.1179

    authors: Simonik DK,Robinson SR,Smotherman WP

    更新日期:1994-12-01 00:00:00

  • Learning and retrieval of concurrently presented spatial discrimination tasks: role of the fornix.

    abstract::In macaque monkeys (Macaco mulatta), memory for scenes presented on touch screens is fornix dependent. However, scene learning is not a purely spatial task, and existing direct evidence for a fornix role in spatial memory comes exclusively from tasks involving learning about food-reward locations. Here the authors dem...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.1.138

    authors: Buckley MJ,Charles DP,Browning PG,Gaffan D

    更新日期:2004-02-01 00:00:00

  • Morris water maze learning in two rat strains increases the expression of the polysialylated form of the neural cell adhesion molecule in the dentate gyrus but has no effect on hippocampal neurogenesis.

    abstract::In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus. Two frequently used rat strains, Wistar and Sprague-Dawley, were trained in the spatial or the nonspatial versi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.4.926

    authors: Van der Borght K,Wallinga AE,Luiten PG,Eggen BJ,Van der Zee EA

    更新日期:2005-08-01 00:00:00

  • Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.

    abstract::The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.5.1006

    authors: Rhodes JS,van Praag H,Jeffrey S,Girard I,Mitchell GS,Garland T Jr,Gage FH

    更新日期:2003-10-01 00:00:00

  • Air-stepping in neonatal rats: A comparison of L-dopa injection and olfactory stimulation.

    abstract::The kinematic parameters of air-stepping induced by 2 methods known to elicit locomotion (olfactory stimulation vs. L-dopa injection) were compared in 3-day-old rats. In the 1st stage, suspended pups were induced to step with an olfactory stimulus of soiled shavings from the nest. In the 2nd stage, they received a sub...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.6.1014

    authors: Jamon M,Maloum I,Riviere G,Bruguerolle B

    更新日期:2002-12-01 00:00:00

  • Muscarinic cholinergic neuromodulation reduces proactive interference between stored odor memories during associative learning in rats.

    abstract::Previous electrophysiological studies and computational modeling suggest the hypothesis that cholinergic neuromodulation may reduce olfactory associative interference during learning (M. E. Hasselmo, B. P. Anderson, & J. M. Bower, 1992; M. E. Hasselmo & J. M. Bower, 1993). These results provide behavioral evidence sup...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: De Rosa E,Hasselmo ME

    更新日期:2000-02-01 00:00:00

  • Reactivation of hippocampal ensemble activity patterns in the aging rat.

    abstract::In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Gerrard JL,Kudrimoti H,McNaughton BL,Barnes CA

    更新日期:2001-12-01 00:00:00

  • Visual asymmetries in Japanese quail (Coturnix japonica) retain a lifelong potential for plasticity.

    abstract::Adult Japanese quail display left-eye/right-hemisphere dominance in visually guided sexual tracking. In 2 experiments, the authors set out to answer if this functional cerebral asymmetry is modifiable by posthatch monocular deprivation. In Experiment 1, the left or the right eye of 2-day old quail were closed for 70 d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016406

    authors: Gülbetekin E,Güntürkün O,Dural S,Cetinkaya H

    更新日期:2009-08-01 00:00:00

  • Long-term study of chronic oral aluminum exposure and spatial working memory in rats.

    abstract::The authors report an effort to advance animal models that mimic the cognitive decline of Alzheimer's disease. Rats were trained and repeatedly tested in a spatial delayed matching-to-position paradigm in the water maze, with the location of the submerged platform changing between, but not within, days. After Trial 1 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.2.351

    authors: von Linstow Roloff E,Platt B,Riedel G

    更新日期:2002-04-01 00:00:00

  • Auditory streaming by phase relations between components of harmonic complexes: a comparative study of human subjects and bird forebrain neurons.

    abstract::Auditory streaming describes a percept in which a sequential series of sounds either is segregated into different streams or is integrated into one stream based on differences in their spectral or temporal characteristics. This phenomenon has been analyzed in human subjects (psychophysics) and European starlings (neur...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0030249

    authors: Dolležal LV,Itatani N,Günther S,Klump GM

    更新日期:2012-12-01 00:00:00

  • Selective sparing after lesions of visual cortex in newborn kittens.

    abstract::Previous findings are discordant regarding the effects of perinatal lesions of Cortical Areas 17 and 18 on visual discrimination learning in cats. Three potential determinants of such sparing were investigated: age at lesion (4 or 181 days), age at testing (3 or 9 months), and stimulus complexity. Age at testing was n...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.6.1176

    authors: Cornwell P,Herbein S,Corso C,Eskew R,Warren JM,Payne B

    更新日期:1989-12-01 00:00:00

  • Amiloride sensitivity in the neonatal rat.

    abstract::Amiloride-sensitive sodium channels in taste buds appear to play a key role in the response to NaCl stimulation, at least in adult rats. The researchers examined whether neonatal rats, which display an exaggerated preference for hypertonic NaCl solutions, lack functional amiloride-sensitive sodium channels. NaCl intak...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.5.981

    authors: Sollars SI,Bernstein IL

    更新日期:1994-10-01 00:00:00

  • Neuroticism and brain responses to anticipatory fear.

    abstract::Personality is known to influence cognitive and affective functioning as well as the risk of psychiatric disorders. Exploration of the neurobiological correlates of personality traits has the potential to enhance understanding of their significance in development of related psychopathological states. The authors exami...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.4.643

    authors: Kumari V,ffytche DH,Das M,Wilson GD,Goswami S,Sharma T

    更新日期:2007-08-01 00:00:00

  • N-methyl-D-aspartate antagonist D-APV selectively disrupts taste-potentiated odor aversion learning.

    abstract::Two experiments examined the effects of the competitive N-methyl-D-aspartate (NMDA) antagonist D-APV (D-2-amino-5-phosphonovalerate) on rats' ability to acquire potentiated aversions to the odor element of a taste-odor compound. In Experiment 1, pretreatment with D-APV (2.5 micrograms/side icv) caused stereospecific d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.2.315

    authors: Willner J,Gallagher M,Graham PW,Crooks GB Jr

    更新日期:1992-04-01 00:00:00

  • Changes in goal selection induced by cue conflicts are in register with predictions from changes in place cell field locations.

    abstract::In the cognitive mapping theory of hippocampal function, currently active place cells represent a rat's spatial location (J. O'Keefe & L. Nadel, 1978). A systematic shift of firing field locations should therefore produce a similar shift in a rat's judgment of its location. A. A. Fenton, G. Csizmadia, and R. U. Muller...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.4.751

    authors: Kubie JL,Fenton A,Novikov N,Touretzky D,Muller RU

    更新日期:2007-08-01 00:00:00

  • Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition.

    abstract::Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice wit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.3.396

    authors: Willott JF,Carlson S

    更新日期:1995-06-01 00:00:00

  • Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.

    abstract::The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mount...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.3.439

    authors: Packard MG,McGaugh JL

    更新日期:1992-06-01 00:00:00

  • The role of central amygdala dopamine in disengagement behavior.

    abstract::Unilateral nigrostriatal dopamine depletion in animals induces contralateral sensorimotor deficits that are like symptoms associated with Parkinson's disease (PD). Unilateral nigrostriatal dopamine depletion also causes a contralateral deficit in disengagement behavior (e.g., ability to stop an ongoing activity to ori...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0031043

    authors: Smith ES,Geissler SA,Schallert T,Lee HJ

    更新日期:2013-04-01 00:00:00