Morris water maze learning in two rat strains increases the expression of the polysialylated form of the neural cell adhesion molecule in the dentate gyrus but has no effect on hippocampal neurogenesis.

Abstract:

:In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus. Two frequently used rat strains, Wistar and Sprague-Dawley, were trained in the spatial or the nonspatial version of the water maze. Both training paradigms did not have an effect on survival of newly formed cells that were labeled 7-9 days prior to the training or on progenitor proliferation in the subgranular zone. However, the granule cell layer of the spatially trained rats contained significantly more positive cells of the polysialylated form of the NCAM. These data demonstrate that Morris water maze learning causes plastic change in the dentate gyrus without affecting hippocampal neurogenesis.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Van der Borght K,Wallinga AE,Luiten PG,Eggen BJ,Van der Zee EA

doi

10.1037/0735-7044.119.4.926

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

926-32

issue

4

eissn

0735-7044

issn

1939-0084

pii

2005-11024-007

journal_volume

119

pub_type

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