Abstract:
:Repeated administration of apomorphine leads to a context-dependent pecking response sensitization. Previously sensitized pigeons (Columba livia) challenged with saline in the same context show a conditioned response (CR). The authors studied the effects of intrastriatal injections of the dopamine (D(1)) antagonist SCH-23390 on both the sensitized response and the CR. When coadministered with apomorphine, SCH-23390 inhibited the initial response to apomorphine, prevented the development of sensitization, and impaired the maintenance of an already developed sensitization. However, SCH-23390 had no effect on the retrieval of a previously established CR. It is concluded that the activation of D(1) receptors in the caudal avian striatum is necessary for the acquisition and maintenance of the sensitization, but not for the expression, of the CR.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Acerbo MJ,Delius JDdoi
10.1037/0735-7044.118.5.1080subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1080-8issue
5eissn
0735-7044issn
1939-0084pii
2004-19432-023journal_volume
118pub_type
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pub_type: 杂志文章
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doi:
更新日期:2000-12-01 00:00:00
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