Conditioned cyclosporine effects but not conditioned taste aversion in immunized rats.

Abstract:

:In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that had previously not been paired with drug injections. In contrast to earlier experiments on conditioned cyclophosphamide effects, rats did not avoid the taste that had previously been paired with drug administration. Thus, conditioned immunopharmacologic effects were not confounded with taste aversion. These observations are interpreted as reflecting an associative learning process that affected the development of an autoimmune disease.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Klosterhalfen S,Klosterhalfen W

doi

10.1037//0735-7044.104.5.716

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

716-24

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

104

pub_type

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