Abstract:
:In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that had previously not been paired with drug injections. In contrast to earlier experiments on conditioned cyclophosphamide effects, rats did not avoid the taste that had previously been paired with drug administration. Thus, conditioned immunopharmacologic effects were not confounded with taste aversion. These observations are interpreted as reflecting an associative learning process that affected the development of an autoimmune disease.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Klosterhalfen S,Klosterhalfen Wdoi
10.1037//0735-7044.104.5.716subject
Has Abstractpub_date
1990-10-01 00:00:00pages
716-24issue
5eissn
0735-7044issn
1939-0084journal_volume
104pub_type
杂志文章abstract::Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less, within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.115.5.971
更新日期:2001-10-01 00:00:00
abstract::Similar to elderly humans, aged Long-Evans rats exhibit individual differences in performance on tasks that critically depend on the medial temporal lobe memory system. Although reduced memory performance is common, close to half of aged rats in this outbred rodent population perform within the range of young subjects...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000332
更新日期:2019-10-01 00:00:00
abstract::An influential view in the field of spatial cognition is that an obligatory geometric module constrains spatial learning and memory. In this issue, P. M. Jones, J. M. Pearce, V. J. Davies, M. A. Good, and A. McGregor (2007) showed that learning based on the geometry, or shape, of the environment requires the hippocamp...
journal_title:Behavioral neuroscience
pub_type: 评论,杂志文章
doi:10.1037/0735-7044.121.6.1442
更新日期:2007-12-01 00:00:00
abstract::The role of the thalamus in memory is potentially very complex. However, most studies on the memory impairments of thalamic lesions have focused on retrospective memory, rarely on prospective memory. To explore the effect of thalamic lesions on event-based prospective memory (EBPM) and time-based prospective memory (T...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0018306
更新日期:2010-02-01 00:00:00
abstract::The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.3.504
更新日期:1989-06-01 00:00:00
abstract::This study examines the effects of positive and negative feedback on performance during choice reaction time tasks to assess whether they differentially affect phasic arousal and tonic activation. Participants (N = 96) received either no feedback or signals of reward, punishment, or both during a semantic and a visuos...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.116.3.397
更新日期:2002-06-01 00:00:00
abstract::The sensitivity of several inbred strains of mice was assessed for ethanol's effects on activity, body temperature, ataxia, balance, and the righting reflex. Genotypic correlations among the mean responses for the strains were estimated as indexes of pleiotropic influences of genes on drug responses. Three major group...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.97.2.280
更新日期:1983-04-01 00:00:00
abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0016328
更新日期:2009-08-01 00:00:00
abstract::Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmen...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.1.116
更新日期:1998-02-01 00:00:00
abstract::The primate dorsolateral prefrontal cortex is implicated in diverse aspects of behavioral regulation, cognitive control, and memory. However, direct neuropsychological evidence supporting a requirement of this area in functions other than spatial working memory has been scarce. T. L. Moore, S. P. Schettler, R. J. Kill...
journal_title:Behavioral neuroscience
pub_type: 评论,杂志文章
doi:10.1037/a0015236
更新日期:2009-04-01 00:00:00
abstract::Acute mid-thoracic spinal cord transection eliminates hindlimb air-stepping in neonatal rats suspended in harnesses and administered L-DOPA. Because spinal cord transection eliminates all descending inputs to the hindlimb locomotor circuits, this experiment determined if coadministration of L-DOPA and quipazine (serot...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.111.4.825
更新日期:1997-08-01 00:00:00
abstract::Sniffing, a behavior that enhances detection and localization of odorants, is typically assumed to require behavioral arousal. In an effort to determine whether sniffing and arousal are dissociable, dimethyl disulfide (DMDS) was presented to 8-day-old rats while respiration and behavioral state were monitored. Pups sn...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.2.267
更新日期:2004-04-01 00:00:00
abstract::PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-behavioral deficits and whether these deficits occur before or after a...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.113.5.982
更新日期:1999-10-01 00:00:00
abstract::Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.6.1475
更新日期:1998-12-01 00:00:00
abstract::The hippocampus is important for the acquisition of new memories. It is also one of the few regions in the adult mammalian brain that can generate new nerve cells. The authors tested the hypothesis that voluntary exercise increases neurogenesis and enhances spatial learning in mice selectively bred for high levels of ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.117.5.1006
更新日期:2003-10-01 00:00:00
abstract::Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the authors examined behavior (social and ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000220
更新日期:2017-12-01 00:00:00
abstract::Lesions of either the dorsomedial thalamus (DMT) or the parafascicular region of the thalamus (PFA) reduced rough-and-tumble social play in juvenile rats, as measured by frequency of pinning. Pinning was reduced by 33% in pups with DMT lesions and by 73% in pups with PFA lesions. Although PFA lesions had minimal effec...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.99.6.1103
更新日期:1985-12-01 00:00:00
abstract::Mild traumatic brain injuries are known to cause a host of symptoms, including headaches, nausea, and depression, that when persistent, are known as postconcussive syndrome. In addition to these overt symptomologies, individuals may experience changes in day-to-day behavior or temperament, which although not meeting c...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000413
更新日期:2020-10-01 00:00:00
abstract::Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1037/bne0000068
更新日期:2015-08-01 00:00:00
abstract::These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.98.5.858
更新日期:1984-10-01 00:00:00
abstract::The rat's willingness to ingest glucose after an initial intraoral intake test was probed by beginning a 2nd intraoral intake test at variable durations (1-120 min). In Experiment 1, after an initial meal of 12.5% glucose solution averaging 26.9 +/- 1.7 ml (SEM, n = 10), the size of the 2nd (probe) meal of the same st...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Animals with sham operations, hippocampal formation, or small and large parietal cortex lesions were trained in a task that required memory for short or long lists of items (spatial locations). More specifically, on any one trial, a rat is presented with 2, 4, 6, 8, or 10 items (spatial locations) on a 12-arm radial m...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.1.84
更新日期:1989-02-01 00:00:00
abstract::When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the response to a dang...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.5.1139
更新日期:1989-10-01 00:00:00
abstract::Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to noc...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.6.1418
更新日期:2004-12-01 00:00:00
abstract::Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little examination of the influences that serotonin receptors may play in modula...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0016882
更新日期:2009-10-01 00:00:00
abstract::Environmental cues associated with drug administration elicit neural activation in circuits involved in cognitive processes and emotional regulation. An important question is whether the neural activation observed is specific to the drug-paired environment or is due to a generalized activation induced by previous drug...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.116.4.727
更新日期:2002-08-01 00:00:00
abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.4.730
更新日期:2004-08-01 00:00:00
abstract::The effects of lesions of the medial dorsal thalamic nucleus (MD) on blocking and latent inhibition (LI) of the rat eyeblink response were examined in the present study. Previous work has demonstrated that the cingulate cortex and related thalamic areas are involved in processing conditioning stimuli throughout traini...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.116.2.276
更新日期:2002-04-01 00:00:00
abstract::Guinea pig pups that were separated from their mothers and placed into a novel environment for 90 min showed an increase in dopamine (DA) turnover (ratio of metabolites to DA) in the septum compared with undisturbed baseline controls. Pups placed into the novel environment with their mothers exhibited an intermediate ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.104.4.607
更新日期:1990-08-01 00:00:00
abstract::Adult male rats consumed 50-150% more 0.5 M NaCl solution than females did during a 7-hr drinking test when robust salt appetite was elicited by dietary sodium deprivation for 8 days, daily injections of deoxycorticosterone, or adrenalectomy followed by 2 days of sodium deprivation. In contrast, male rats drank much l...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00