Conditioned cyclosporine effects but not conditioned taste aversion in immunized rats.


:In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that had previously not been paired with drug injections. In contrast to earlier experiments on conditioned cyclophosphamide effects, rats did not avoid the taste that had previously been paired with drug administration. Thus, conditioned immunopharmacologic effects were not confounded with taste aversion. These observations are interpreted as reflecting an associative learning process that affected the development of an autoimmune disease.


Behav Neurosci


Behavioral neuroscience


Klosterhalfen S,Klosterhalfen W




Has Abstract


1990-10-01 00:00:00












  • Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.

    abstract::In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dunnett SB,Ryan CN,Levin PD,Reynolds M,Bunch ST

    更新日期:1987-08-01 00:00:00

  • The behavioral effects of chronic sugar and/or caffeine consumption in adult and adolescent rats.

    abstract::Caffeine is a psychostimulant frequently consumed by adults and children, often in combination with high levels of sugar. Chronic pretreatment with either substance can amplify both amphetamine and cocaine-induced hyperactivity in rodents. The present study sought to elucidate whether age at the time of exposure to su...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Franklin JL,Wearne TA,Homewood J,Cornish JL

    更新日期:2017-08-01 00:00:00

  • Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome.

    abstract::In humans, congenital deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a disorder known as the Lesch-Nyhan syndrome. Patients with this disorder exhibit a prominent neurobehavioral phenotype that results in part from dysfunction of catecholaminergic systems in the striatum. HPR...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Jinnah HA,Gage FH,Friedmann T

    更新日期:1991-12-01 00:00:00

  • Loudness scaling and masking in rats.

    abstract::Two groups of rats were trained on operant discriminations in which the discriminanda were two different sound pressure levels of a 4-kHz tone. The discriminanda were chosen so that the loudness difference between stimuli was equivalent for each group when calculated from a power function with an exponent of .35. Half...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Raslear TG,Pierrel-Sorrentino R,Rudnick F

    更新日期:1983-06-01 00:00:00

  • Reversible lesions of the nucleus of the solitary tract attenuate the memory-modulating effects of posttraining epinephrine.

    abstract::Rats implanted with cannula tips placed above the nucleus of the solitary tract (NTS) were trained to obtain food pellets placed in 2 arms of a Y maze and then given a footshock in 1 arm of the maze. The rats then received bilateral injections of lidocaine or buffer into the NTS and peripheral injections of saline or ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Williams CL,McGaugh JL

    更新日期:1993-12-01 00:00:00

  • Effects of parturition and maternal experience on noradrenaline and acetylcholine release in the olfactory bulb of sheep.

    abstract::Acetylcholine (ACh) and noradrenaline (NA) release in the olfactory bulb (OB) of ewes was monitored using microdialysis. Both ACh and NA release increased at parturition in multiparous but not in primiparous ewes. However, vaginocervical stimulation performed 6 hr postpartum induced an increase of ACh and NA release i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lévy F,Guevara-Guzman R,Hinton MR,Kendrick KM,Keverne EB

    更新日期:1993-08-01 00:00:00

  • Dissociation of conditioned locomotion and Fos induction in response to stimuli formerly paired with cocaine.

    abstract::A discrete stimulus (flashing light) was paired with cocaine (20 mg/kg) to induce conditioned locomotion. To identify brain regions activated during this response, Fos was measured with immunohistochemistry. Although paired subjects displayed robust conditioned locomotion, Fos was not increased in any limbic brain reg...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Hotsenpiller G,Horak BT,Wolf ME

    更新日期:2002-08-01 00:00:00

  • Memory stages and brain asymmetry in chick learning.

    abstract::Stages of formation of memory and the roles of different forebrain structures in memory formation were investigated by injecting various agents into the brains of chicks close to the time of peck-avoidance training. With L-glutamate injected bilaterally into the hyperstriatum 5 min pretraining, retention was good 1 mi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Patterson TA,Alvarado MC,Warner IT,Bennett EL,Rosenzweig MR

    更新日期:1986-12-01 00:00:00

  • Neonatal chorda tympani transection alters adult preference for ammonium chloride in the rat.

    abstract::The immature gustatory system of the neonatal rat is characterized by sensitivity to disruption by early interventions such as receptor or nerve damage. The present studies examined the effect of chorda tympani transection (neoCTX) of neonates on adult preference for salt and nonsalt stimuli. NeoCTX at 10 days of age ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sollars SI,Bernstein IL

    更新日期:1996-06-01 00:00:00

  • Trigeminal lesions and maternal behavior in Norway rats: I. Effects of cutaneous rostral snout denervation on maintenance of nurturance and maternal aggression.

    abstract::Cutaneous desensitization of the upper, rostral snout by bilateral section of the infraorbital nerves in lactating Norway rat dams markedly, but transiently, disrupted retrieval and licking of pups, nursing behavior, and fighting with a strange male intruder. Removal of the mystacial vibrissae, which provide major inp...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Stern JM,Kolunie JM

    更新日期:1991-12-01 00:00:00

  • Delayed spontaneous alternation in intact and cerebellectomized control and lurcher mutant mice: differential role of cerebellar cortex and deep cerebellar nuclei.

    abstract::Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Caston J,Vasseur F,Delhaye-Bouchaud N,Mariani J

    更新日期:1997-02-01 00:00:00

  • Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice.

    abstract::Neuropsin (kallikrein-related peptidase 8) is concentrated in the hippocampus, amygdala, olfactory bulb, and prefrontal cortex. Earlier studies showed that protease deficiency causes a significant impairment of early-phase long-term potentiation in the Schaffer collateral pathway and hippocampus-dependent memory in th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Horii Y,Yamasaki N,Miyakawa T,Shiosaka S

    更新日期:2008-06-01 00:00:00

  • Spatial problem solving in a dual runway task by normal and septal rats.

    abstract::The addition of a dual runway configuration did not disrupt the successful performance of normal animals, nor did it improve the deficit of septal rats on the Maier three-table spatial integration task. Both groups of animals displayed a preference for the outside runway configuration during exploration. During testin...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Herrmann T,Poucet B,Ellen P

    更新日期:1985-08-01 00:00:00

  • What does a pigeon (Columba livia) brain look like during homing? selective examination of ZENK expression.

    abstract::Lesion studies have shown that the avian hippocampus plays a crucial role in homing pigeon (Columba livia) navigation. Using the expression of the immediate early gene protein ZENK in intact pigeons, the authors found regional variation in hippocampal activation as a consequence of homing and, necessarily, the behavio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Shimizu T,Bowers AN,Budzynski CA,Kahn MC,Bingman VP

    更新日期:2004-08-01 00:00:00

  • Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.

    abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robinson-Drummer PA,Dokovna LB,Heroux NA,Stanton ME

    更新日期:2016-04-01 00:00:00

  • Morphine influences on classical aversive conditioned heart rate in rats.

    abstract::The present series of three experiments was concerned with the effects of morphine and the morphine antagonist naloxone on the development of a classical aversive heart rate (HR) conditioned response (CR) to a tone conditioned stimulus (CS) paired with an electric shock unconditioned stimulus (US). In the first study,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Mahalik T,Fitzgerald RD

    更新日期:1988-04-01 00:00:00

  • Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.

    abstract::Previous studies on drug abuse have shown that response to drug-associated cues exist during prolonged abstinence. In succession to previous investigations in our laboratory on morphine dependence and our research on acquisition and expression phases of morphine-conditioned place preference (CPP), in this study we att...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Namvar P,Zarrabian S,Nazari-Serenjeh F,Sadeghzadeh F,Haghparast A

    更新日期:2019-12-01 00:00:00

  • Habituation of the acoustic and the tactile startle responses in mice: two independent sensory processes.

    abstract::To test whether habituation is specific to the stimulus modality, the authors analyzed cross-habituation between the tactile startle response' (TSR) and the acoustic startle response (ASR). The acoustic artifacts of airpuffs used to elicit the TSR were reduced by using a silencer and were effectively masked by backgro...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pilz PK,Carl TD,Plappert CF

    更新日期:2004-10-01 00:00:00

  • Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans.

    abstract::The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with th...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Epstein LH,Temple JL,Neaderhiser BJ,Salis RJ,Erbe RW,Leddy JJ

    更新日期:2007-10-01 00:00:00

  • Role of instrumental learning in tolerance to cathinone hypophagia.

    abstract::The effects of dl-cathinone on milk intake and motor activity were investigated in bottle- and cannula-fed rats. Acute injections of cathinone produced dose-dependent increases in activity in both groups but only produced decreased intake in bottle-fed rats. With chronic injections, tolerance to the suppression of int...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wolgin DL,Munoz JR

    更新日期:2006-04-01 00:00:00

  • Air-stepping in neonatal rats: A comparison of L-dopa injection and olfactory stimulation.

    abstract::The kinematic parameters of air-stepping induced by 2 methods known to elicit locomotion (olfactory stimulation vs. L-dopa injection) were compared in 3-day-old rats. In the 1st stage, suspended pups were induced to step with an olfactory stimulus of soiled shavings from the nest. In the 2nd stage, they received a sub...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Jamon M,Maloum I,Riviere G,Bruguerolle B

    更新日期:2002-12-01 00:00:00

  • One-trial odor-reward association: a form of event memory not dependent on hippocampal function.

    abstract::To examine whether the hippocampus is required for memory for unique experiences independent of their spatial or temporal context, the authors devised a novel task that requires rats to remember odor-reward associations formed within a single training trial. Unlike previous tests of 1-trial memory, in this task new as...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wood ER,Agster KM,Eichenbaum H

    更新日期:2004-06-01 00:00:00

  • Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.

    abstract::The present study examined the effect of lesions of the caudate nucleus or fimbria-fornix on the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual patterns were used as platforms (i.e., cues). The "correct" cue was attached to a submerged rectangular platform and could be mount...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Packard MG,McGaugh JL

    更新日期:1992-06-01 00:00:00

  • Influence of opioid peptides on learning and memory processes in the chick.

    abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Patterson TA,Schulteis G,Alvarado MC,Martinez JL Jr,Bennett EL,Rosenzweig MR,Hruby VJ

    更新日期:1989-04-01 00:00:00

  • Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell-degeneration mutant mice.

    abstract::The authors have previously demonstrated that Purkinje cell-degeneration (pcd) mutant mice are impaired in eyeblink conditioning (L. Chen et al., 1996a). The present study addresses the following 3 questions: (a) whether pcd mice perceive the conditioned and unconditioned stimuli as well as the wild-type mice, (b) whe...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Chen L,Bao S,Thompson RF

    更新日期:1999-02-01 00:00:00

  • Specificity of the cardiac response to conspecific vocalization in chimpanzees.

    abstract::Heart rate measures were used to examine the functional response of young chimpanzees and orangutans to acoustic stimuli, including white noise and chimpanzee vocalizations (threat, stress, and alarm). The initial response of the animals to all stimuli was characterized by a prominent cardiac deceleration and an incre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Berntson GG,Boysen ST

    更新日期:1989-04-01 00:00:00

  • Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.

    abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pratt WE,Kelley AE

    更新日期:2004-08-01 00:00:00

  • Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans.

    abstract::The effects of various doses (40 microg/kg/hr, 300 microg/kg/hr, 600 microg/kg/hr or placebo) of hydrocortisone on tasks assessing working and declarative memory function were measured in 4 groups of 10 young men. During the infusion, participants were given an item-recognition working memory task, a paired-associate ...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lupien SJ,Gillin CJ,Hauger RL

    更新日期:1999-06-01 00:00:00

  • Place navigation in rats with unilateral tetrodotoxin inactivation of the dorsal hippocampus: place but not procedural learning can be lateralized to one hippocampus.

    abstract::Lateralization of the Morris water maze task was examined by injecting 5 ng of tetrodotoxin (TTX) into one dorsal hippocampus (HPC) of chronically cannulated rats (n = 20). The task, acquired (A) during unilateral HPC block, was retrieved (R) during TTX blockade of the ipsi- (I) or contralateral (C) HPC. Escape latenc...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Fenton AA,Bures J

    更新日期:1993-08-01 00:00:00

  • Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory.

    abstract::Preadolescent mice have been shown to be differentially susceptible to the effects of both acute and chronic nicotine exposure on contextual fear learning relative to adults. For this study, we tested the effects of chronic nicotine exposure in preadolescence on adulthood extinction and spontaneous recovery of fear me...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Zeid D,Gould TJ

    更新日期:2018-08-01 00:00:00