The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys (Macaca mulatta).

Abstract:

:Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less, within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn them when given several daily sessions. Thus, relatively slow, across-session visuomotor learning depends on neither the ventral nor orbital prefrontal cortex, but rapid, within-session learning does. The ablations also eliminated at least 2 response strategies, repeat-stay and lose-shift, which might account, in part, for the deficit in rapid learning. The deficit is unlikely to result from a failure of visual discriminative ability or working memory: The monkeys could discriminate similar stimulus material within a session, and reducing the working memory load did not improve within-session learning.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Bussey TJ,Wise SP,Murray EA

doi

10.1037//0735-7044.115.5.971

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

971-82

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

115

pub_type

杂志文章
  • Processing of preconsciously acquired information measured by hemispheric asymmetry and selection accuracy.

    abstract::This study was conducted to investigate the effects of instruction types on hemispheric activation and accurate selection of spatial stimuli that had been previously presented at a subliminal level. Right-handed females randomly received either an "analytic" or a "holistic" instruction. Both groups first saw a series ...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//0735-7044.100.3.343

    authors: Barchas PR,Perlaki KM

    更新日期:1986-06-01 00:00:00

  • Parametric investigation of social place preference in adolescent mice.

    abstract::Social interaction promotes survival by helping animals to form stable and supportive groups. Additionally, maladaptive social behavior is a hallmark of disorders such as autism and schizophrenia. In many different animal species, including humans, social interaction can be inherently rewarding. Lately there has been ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000406

    authors: Cann C,Venniro M,Hope BT,Ramsey LA

    更新日期:2020-10-01 00:00:00

  • Behavioral sensitization to cocaine, but not cocaine-conditioned behavior, is associated with increased dopamine occupation of its receptors in the nucleus accumbens.

    abstract::Rats had repeated treatments with cocaine associated with a specific context (paired group). Evidence for classical conditioning of cocaine's motor-activity effects and context-specific behavioral sensitization to cocaine was obtained, relative to vehicle-treated (control) and pseudoconditioned (unpaired) groups. Only...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.6.1388

    authors: Burechailo L,Martin-Iverson MT

    更新日期:1996-12-01 00:00:00

  • Oral methylphenidate improves spatial learning and memory in pre- and periadolescent rats.

    abstract::Methylphenidate (MPD) is widely prescribed for attention-deficit/hyperactivity disorder in the United States. Patients, mostly school-age children, are taking the drug orally. To simulate the human condition, the authors used a cracker to administer methylphenidate orally (without the stress of handling) from Postnata...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.121.6.1272

    authors: Zhu N,Weedon J,Dow-Edwards DL

    更新日期:2007-12-01 00:00:00

  • Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

    abstract::Chorda tympani nerve (CT) transection (CTX) raises sodium chloride (NaCl) taste detection threshold, but the effect of CT regeneration on NaCl threshold is unknown. This experiment examined whether CT regeneration supports normal NaCl threshold in the rat. Thresholds were measured with a 2-lever operant procedure. Thr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Kopka SL,Spector AC

    更新日期:2001-10-01 00:00:00

  • Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD).

    abstract::Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.6.1475

    authors: Szechtman H,Sulis W,Eilam D

    更新日期:1998-12-01 00:00:00

  • Behavioral sensitization to apomorphine in pigeons (Columba livia): blockade by the D1 dopamine antagonist SCH-23390.

    abstract::Repeated administration of apomorphine leads to a context-dependent pecking response sensitization. Previously sensitized pigeons (Columba livia) challenged with saline in the same context show a conditioned response (CR). The authors studied the effects of intrastriatal injections of the dopamine (D(1)) antagonist SC...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.5.1080

    authors: Acerbo MJ,Delius JD

    更新日期:2004-10-01 00:00:00

  • Mnemonic theories of hippocampal function.

    abstract::Although mnemonic interpretations of hippocampal function in people have been readily accepted for many years, similar interpretations of hippocampal function in animals have received a number of challenges. This article reviews two of these challenges, shows how they were resolved in favor of some kind of mnemonic in...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审

    doi:10.1037//0735-7044.100.6.852

    authors: Olton DS,Wible CG,Shapiro ML

    更新日期:1986-12-01 00:00:00

  • Behavioral thermoregulation, core temperature, and motor activity: simultaneous quantitative assessment in rats after dopamine and prostaglandin E1.

    abstract::These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.5.858

    authors: Marques PR,Spencer RL,Burks TF,McDougal JN

    更新日期:1984-10-01 00:00:00

  • Pelvic and pudendal nerves influence the display of paced mating behavior in response to estrogen and progesterone in the female rat.

    abstract::Two experiments examined whether the pudendal and pelvic autonomic nerves are important for pacing behavior shown by the female rat during mating. Ovariectomized female rats received bilateral transection of the pudendal (Pux), pelvic (Pex), or pudendal and pelvic (Pu + Pex) nerves or were sham-operated (Shx). Lordoti...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.4.690

    authors: Erskine MS

    更新日期:1992-08-01 00:00:00

  • Tonic and phasic activation and arousal effects as a function of feedback in repetitive-choice reaction time tasks.

    abstract::This study examines the effects of positive and negative feedback on performance during choice reaction time tasks to assess whether they differentially affect phasic arousal and tonic activation. Participants (N = 96) received either no feedback or signals of reward, punishment, or both during a semantic and a visuos...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.116.3.397

    authors: De Brabander B,Declerck CH,Boone C

    更新日期:2002-06-01 00:00:00

  • Either main or accessory olfactory system signaling can mediate the rewarding effects of estrous female chemosignals in sexually naive male mice.

    abstract::A long-held view has been that interest of male mice in female body odors reflects an activation of reward circuits in the male brain following their detection by the vomeronasal organ (VNO) and processing via the accessory olfactory system. We found that adult, sexually naive male mice acquired a conditioned place pr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0033945

    authors: Korzan WJ,Freamat M,Johnson AG,Cherry JA,Baum MJ

    更新日期:2013-10-01 00:00:00

  • Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice.

    abstract::Neuromuscular impairment by ethanol likely involves complex effects on balance, gait, muscle strength, and other features of motor coordination. The present experiments showed that relative sensitivity to ethanol-induced motor impairment in serotonin 1B (5-HT(1B)) null mutant and control mice was task dependent. We fo...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Boehm SL 2nd,Schafer GL,Phillips TJ,Browman KE,Crabbe JC

    更新日期:2000-04-01 00:00:00

  • A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preference.

    abstract::Previous work has demonstrated an important role for adrenergic receptors in memory processes in fear and drug conditioning paradigms. Recent studies have also demonstrated alterations in extinction in these paradigms using drug treatments targeting beta- and alpha2-adrenergic receptors, but little is known about the ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0018909

    authors: Bernardi RE,Lattal KM

    更新日期:2010-04-01 00:00:00

  • The lasting effects of spike insoles on postural control in the elderly.

    abstract::The purpose of the present study was to explore the lasting effects of a tactile sensitivity enhancement induced by spike insoles on the control of stance in the elderly. Healthy elderly subjects (n = 19, mean age = 68.8) and young adults (n = 17, mean age = 24.3) were instructed to stand or to walk for 5 minutes with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0017115

    authors: Palluel E,Olivier I,Nougier V

    更新日期:2009-10-01 00:00:00

  • Does intranasal application of zinc sulfate produce anosmia in the rat?

    abstract::Transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from olfactory sensory neurons to the olfactory bulb as well as odor detection and discrimination were examined in rats in which each nasal epithelium had been irrigated with 0.1-0.5 ml 5% zinc sulfate. After treatment, rats showed few or no deficits ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Slotnick B,Glover P,Bodyak N

    更新日期:2000-08-01 00:00:00

  • Functional consequences of embryonic neocortex transplanted to rats with prefrontal cortex lesions.

    abstract::In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.4.489

    authors: Dunnett SB,Ryan CN,Levin PD,Reynolds M,Bunch ST

    更新日期:1987-08-01 00:00:00

  • Habituation of the acoustic and the tactile startle responses in mice: two independent sensory processes.

    abstract::To test whether habituation is specific to the stimulus modality, the authors analyzed cross-habituation between the tactile startle response' (TSR) and the acoustic startle response (ASR). The acoustic artifacts of airpuffs used to elicit the TSR were reduced by using a silencer and were effectively masked by backgro...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.5.975

    authors: Pilz PK,Carl TD,Plappert CF

    更新日期:2004-10-01 00:00:00

  • Conditioning and contextual retrieval in hippocampal rats.

    abstract::The role of the hippocampus in associative learning was investigated in 3 experiments with rats as subjects. Hippocampal rats were impaired in the acquisition of conditioned responding both when food was signaled by the insertion of a lever (Experiment 1) and when the presentation of auditory or visual events served a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.4.499

    authors: Good M,Honey RC

    更新日期:1991-08-01 00:00:00

  • Head direction, place, and movement correlates for cells in the rat retrosplenial cortex.

    abstract::The retrosplenial cortex is strongly connected with brain regions involved in spatial signaling. To test whether it also codes space, single cells were recorded while rats navigated in an open field. As in earlier work (L. L. Chen, L. H. Lin, C. A. Barnes, & B. L. McNaughton, 1994; L. L. Chen, L. H. Lin, E. J. Green, ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.115.1.3

    authors: Cho J,Sharp PE

    更新日期:2001-02-01 00:00:00

  • Premotor cortex in the rat.

    abstract::Donoghue and Wise (1982) identified an area AGm in the rat that they take to be a nonprimary motor area. In the present experiments, therefore, this area was removed bilaterally in rats. The animals were poor at relearning a visual conditional motor task but were able to learn spatial delayed alternation as rapidly as...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.1.101

    authors: Passingham RE,Myers C,Rawlins N,Lightfoot V,Fearn S

    更新日期:1988-02-01 00:00:00

  • Footshock-induced sensitization of electrically elicited startle reflexes.

    abstract::The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.3.504

    authors: Boulis NM,Davis M

    更新日期:1989-06-01 00:00:00

  • Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala.

    abstract::The cAMP-responsive element binding protein (CREB) is a transcription factor that regulates synaptic plasticity and memory formation. Studies that have used conditioned fear models have established that CREB is important for the acquisition and consolidation of fear learning. The authors demonstrate that overexpressio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.4.1125

    authors: Jasnow AM,Shi C,Israel JE,Davis M,Huhman KL

    更新日期:2005-08-01 00:00:00

  • Conditioned place preference for mating is preserved in rats with pelvic nerve transection.

    abstract::Female rats exhibit a conditioned place preference (CPP) for a context paired with mating. The present experiment tested the hypothesis that the activation of the pelvic nerve mediates the reinforcing effects of mating for female rats. Rats underwent bilateral pelvic nerve or sham transection and then received paced m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0015267

    authors: Meerts SH,Clark AS

    更新日期:2009-06-01 00:00:00

  • Environmental enrichment as a therapy for autism: A clinical trial replication and extension.

    abstract::Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/bne0000068

    authors: Woo CC,Donnelly JH,Steinberg-Epstein R,Leon M

    更新日期:2015-08-01 00:00:00

  • Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine.

    abstract::Large neocortical injuries can interfere with the initial performance of many previously learned behaviors. This dysfunction, however, may not be attributable to the loss of the memories of learned behaviors but to a failure to access memories that are spared. The results of this experiment support this hypothesis by ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.3.561

    authors: LeVere TE,Brugler T,Sandin M,Gray-Silva S

    更新日期:1989-06-01 00:00:00

  • Dissociations between appetitive and consummatory responses by pharmacological manipulations of reward-relevant brain regions.

    abstract::Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.110.2.331

    authors: Ikemoto S,Panksepp J

    更新日期:1996-04-01 00:00:00

  • Involvement of serotonin and oxytocin in neural mechanism regulating amicable social signal in male mice: Implication for impaired recognition of amicable cues in BALB/c strain.

    abstract::Social signals play a primary role in regulating social relationships among male mice. The present series of experiments investigated the neural mechanisms underlying an induction of amicable cues that facilitate social approach in male mice of the C57BL/6 (B6) and BALB/c (BALB) strains. Male mice exhibit approach beh...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000191

    authors: Arakawa H

    更新日期:2017-04-01 00:00:00

  • Interaction between recovery from behavioral asymmetries induced by hemivibrissotomy in the rat and the effects of apomorphine and amphetamine.

    abstract::Spontaneous and drug-induced turning behavior and thigmotactic scanning were tested either acutely (4-6 hr) or chronically (9 days) after unilateral removal of vibrissae in rats. Rats that were tested acutely scanned more with the intact vibrissae side. This asymmetry was reduced in rats that were tested chronically, ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.3.470

    authors: Milani H,Schwarting RK,Kumpf S,Steiner H,Huston JP

    更新日期:1990-06-01 00:00:00

  • Frontal cortex lesions block the opioid and nonopioid hypoalgesia elicited by brief shocks but not the nonopioid hypoalgesia elicited by long shocks.

    abstract::Previous research (Grau, 1987a, 1987b) suggests that forebrain systems play an essential role in the hypoalgesia observed after brief shock but not long shock. Additional research has shown that pentobarbital anesthesia and decerebration block the hypoalgesia observed after 3 brief (0.75-s) shocks but not the hypoalge...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.6.1366

    authors: Meagher MW,Grau JW,King RA

    更新日期:1989-12-01 00:00:00