Abstract:
:Social interaction promotes survival by helping animals to form stable and supportive groups. Additionally, maladaptive social behavior is a hallmark of disorders such as autism and schizophrenia. In many different animal species, including humans, social interaction can be inherently rewarding. Lately there has been growing interest in studying the neurobiological underpinnings of social interaction and learned social behavior in rodent behavioral models. One common procedure is conditioned place preference (CPP) to measure the rewarding effects of social interaction and social reward learning. Social CPP was originally used in rats but has been adapted recently for use in mice, enabling use of the vast array of genetic tools available in mice. Here we studied the role of age, sex, bedding, and prior social isolation on the expression of social CPP in male and female mice. We found that without social deprivation male mice display moderate and temporary social CPP during early adolescence but not adulthood. Early life social isolation increased social CPP in female but not male mice. In contrast, cocaine CPP was robust and long-lasting in male and female mice. Our results demonstrate that social CPP in mice is variable, occurring under only specific conditions, and that social isolation promotes social reward in female but not male mice. We discuss potential methodological and interpretive issues of the mouse social CPP model. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Cann C,Venniro M,Hope BT,Ramsey LAdoi
10.1037/bne0000406subject
Has Abstractpub_date
2020-10-01 00:00:00pages
435-443issue
5eissn
0735-7044issn
1939-0084pii
2020-51968-001journal_volume
134pub_type
杂志文章abstract::The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...
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