Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape.

Abstract:

:Exercise can reduce symptoms of depression and anxiety in humans, but therapeutic effects of exercise in an animal model of stress-related mood disorders have yet to be demonstrated. In the current study, the authors investigated the ability of wheel running to reverse a long-lasting interference with shuttle box escape produced by uncontrollable stress. Rats who remained sedentary following uncontrollable foot shock demonstrated robust conditioned freezing behavior to the stressor environment and deficits in shuttle box escape learning. Voluntary access to running wheels for 6 weeks, but not 2 weeks, following uncontrollable foot shock reduced the expression of conditioned freezing and reversed the escape deficit. Results demonstrate a long-lasting interference with shuttle box escape that can be reversed by exercise in a duration-dependent fashion.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Greenwood BN,Strong PV,Dorey AA,Fleshner M

doi

10.1037/0735-7044.121.5.992

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

992-1000

issue

5

eissn

0735-7044

issn

1939-0084

pii

2007-13974-017

journal_volume

121

pub_type

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