Abstract:
:Dopaminergic blocking agents have been known to suppress intracranial self-stimulation, but whether the suppression results from a reduction in the rewarding value of stimulation or from motor deficits has remained controversial. We have resolved this controversy by developing an operant technique minimally dependent on motor activity: Rats were trained to perform a bar-holding response for 3s or to produce hippocampal theta waves for 3s when the bar was retracted. Decamethonium bromide (a muscle relaxant) reduced bar holding without affecting theta production for brain stimulation. Pimozide (a dopaminergic blocking-agent) reduced both bar holding and theta production for stimulation, though rats were still capable of making the theta response at a rate comparable to the preinjection rate. Dopaminergic blocking at low doses reduces the rewarding value of brain stimulation at the level of the lateral hypothalamus. The method described in this report has wide applicability.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Fantie BD,Nakajima Sdoi
10.1037//0735-7044.101.5.626subject
Has Abstractpub_date
1987-10-01 00:00:00pages
626-33issue
5eissn
0735-7044issn
1939-0084journal_volume
101pub_type
杂志文章abstract::The effects of postingestive feedback on the value of intraoral sucrose and lateral hypothalamic (LH) stimulation were compared. Rats chose between a fixed LH stimulation train or a compound reward composed of the same stimulation train and an oral infusion of 1 M sucrose. The rats preferred the compound reward when p...
journal_title:Behavioral neuroscience
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pub_type: 杂志文章,随机对照试验
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