Operant conditioning of hippocampal theta: dissociating reward from performance deficits.

Abstract:

:Dopaminergic blocking agents have been known to suppress intracranial self-stimulation, but whether the suppression results from a reduction in the rewarding value of stimulation or from motor deficits has remained controversial. We have resolved this controversy by developing an operant technique minimally dependent on motor activity: Rats were trained to perform a bar-holding response for 3s or to produce hippocampal theta waves for 3s when the bar was retracted. Decamethonium bromide (a muscle relaxant) reduced bar holding without affecting theta production for brain stimulation. Pimozide (a dopaminergic blocking-agent) reduced both bar holding and theta production for stimulation, though rats were still capable of making the theta response at a rate comparable to the preinjection rate. Dopaminergic blocking at low doses reduces the rewarding value of brain stimulation at the level of the lateral hypothalamus. The method described in this report has wide applicability.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Fantie BD,Nakajima S

doi

10.1037//0735-7044.101.5.626

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

626-33

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

101

pub_type

杂志文章
  • Differential effects of postingestive feedback on the reward value of sucrose and lateral hypothalamic stimulation in rats.

    abstract::The effects of postingestive feedback on the value of intraoral sucrose and lateral hypothalamic (LH) stimulation were compared. Rats chose between a fixed LH stimulation train or a compound reward composed of the same stimulation train and an oral infusion of 1 M sucrose. The rats preferred the compound reward when p...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.3.559

    authors: Conover KL,Shizgal P

    更新日期:1994-06-01 00:00:00

  • Dopamine-stimulated sexual behavior is testosterone dependent in mice.

    abstract::Mice unable to synthesize dopamine (DA) in dopaminergic neurons were generated by gene-targeting techniques (Q.-Y. Zhou & R. D. Palmiter, 1995). These dopamine-deficient (DA-/-) mice required daily administration of 3,4-dihydroxyphenylalanine (L-DOPA) for survival beyond 2 to 3 weeks of age. This treatment stimulated ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.5.1229

    authors: Szczypka MS,Zhou QY,Palmiter RD

    更新日期:1998-10-01 00:00:00

  • Postnatal choline supplementation in preweanling mice: sexually dimorphic behavioral and neurochemical effects.

    abstract::The aim of this study was to investigate the effects of postnatal choline supplementation on neurochemical and behavioral parameters in preweanling BALB/cByJ mice. Mouse pups were injected daily subcutaneously with choline chloride (0.85 mM/g body weight) from Postnatal Day (PND) 1 to PND 16. Pups performed a passive ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Ricceri L,Berger-Sweeney J

    更新日期:1998-12-01 00:00:00

  • Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).

    abstract::Female songbirds use male songs as an important criterion for mate selection. Several studies have reported that female songbirds prefer complex songs to other song types. In a recent study, the authors found that song responsiveness in female zebra finches (Taeniopygia guttata) is strongly modulated by circulating es...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.5.1148

    authors: Vyas A,Harding C,McGowan J,Snare R,Bogdan D

    更新日期:2008-10-01 00:00:00

  • Strychnine increases acoustic startle amplitude but does not alter short-term or long-term habituation.

    abstract::Theories of habituation have included an increase in postsynaptic inhibition as one possible mechanism underlying response decrement following repetitive stimulus presentation. In this study, the glycine antagonist strychnine (1.0 mg/kg, ip, 10 min pretreatment) was used to investigate the involvement of glycinergic n...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.6.955

    authors: Kehne JH,Davis M

    更新日期:1984-12-01 00:00:00

  • Does shape matter? Theoretical comment on Jones, Pearce, Davies, Good, and McGregor (2007).

    abstract::An influential view in the field of spatial cognition is that an obligatory geometric module constrains spatial learning and memory. In this issue, P. M. Jones, J. M. Pearce, V. J. Davies, M. A. Good, and A. McGregor (2007) showed that learning based on the geometry, or shape, of the environment requires the hippocamp...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/0735-7044.121.6.1442

    authors: Dudchenko PA

    更新日期:2007-12-01 00:00:00

  • Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition.

    abstract::Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice wit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.3.396

    authors: Willott JF,Carlson S

    更新日期:1995-06-01 00:00:00

  • Nonlinear temporal integration of brain stimulation reward.

    abstract::A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, altho...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026180

    authors: Hawkins RD

    更新日期:2011-12-01 00:00:00

  • Stimulation of 5-HT2A receptors recovers sensory responsiveness in acute spinal neonatal rats.

    abstract::Quipazine is a 5-HT2A-receptor agonist that has been used to induce motor activity and promote recovery of function after spinal cord injury in neonatal and adult rodents. Sensory stimulation also activates sensory and motor circuits and promotes recovery after spinal cord injury. In rats, tail pinching is an effectiv...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000176

    authors: Swann HE,Kauer SD,Allmond JT,Brumley MR

    更新日期:2017-02-01 00:00:00

  • Fat substitutes promote weight gain in rats consuming high-fat diets.

    abstract::The use of food products designed to mimic the sensory properties of sweet and fat while providing fewer calories has been promoted as a method for reducing food intake and body weight. However, such products may interfere with a learned relationship between the sensory properties of food and the caloric consequences ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0024404

    authors: Swithers SE,Ogden SB,Davidson TL

    更新日期:2011-08-01 00:00:00

  • Reinnervation of the dentate gyrus and recovery of alternation behavior following entorhinal cortex lesions.

    abstract::Adult male rats were implanted with chronically indwelling recording electrodes in the dentate hilus of one hemisphere and bipolar stimulating electrodes in the contralateral entorhinal cortex (EC). Daily measurements were then made of the amplitude of responses, evoked through the crossed temporodentate (CTD) pathway...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.101.2.179

    authors: Reeves TM,Smith DC

    更新日期:1987-04-01 00:00:00

  • Morphine influences on classical aversive conditioned heart rate in rats.

    abstract::The present series of three experiments was concerned with the effects of morphine and the morphine antagonist naloxone on the development of a classical aversive heart rate (HR) conditioned response (CR) to a tone conditioned stimulus (CS) paired with an electric shock unconditioned stimulus (US). In the first study,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.2.244

    authors: Mahalik T,Fitzgerald RD

    更新日期:1988-04-01 00:00:00

  • Developmental exposure to methimazole increases anxiety behavior in zebrafish.

    abstract::The role of thyroid hormones in vertebrate development has been well documented for several decades. As hypothyroidism during critical periods of development can cause defects to the development of every major organ system, including brain, eye, and general morphology, we hypothesized that hypothyroidism would affect ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000087

    authors: Reider M,Connaughton VP

    更新日期:2015-10-01 00:00:00

  • Strain differences in patterns of drug-intake during prolonged access to cocaine self-administration.

    abstract::The current study examined possible interactions between genetic factors and prolonged drug access by testing the Fischer (F344), Lewis (LEW), and Wistar rat strains in a prolonged access cocaine self-administration (SA) procedure. Before prolonged access, the strains did not differ in breakpoints for food or cocaine ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0013727

    authors: Freeman KB,Kearns DN,Kohut SJ,Riley AL

    更新日期:2009-02-01 00:00:00

  • Reinforcing properties of ejaculation in the male rat: role of opioids and dopamine.

    abstract::Ejaculation-induced reward in the male rat was evaluated by the conditioned place-preference paradigm. It was supposed that ejaculation induces a reward state such that it can be conditioned to environmental stimuli. Males were allowed to ejaculate once and were then immediately transferred to a place-preference cage....

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.1.177

    authors: Agmo A,Berenfeld R

    更新日期:1990-02-01 00:00:00

  • The role of the cerebellar interpositus nucleus in short and long term memory for trace eyeblink conditioning.

    abstract::In previous studies the cerebellar interpositus (IP) nucleus, but not the hippocampus, was shown to be necessary both for initial learning and retention and for long-term retention of the standard delay eyeblink conditioned response (CR). However, in the trace eyeblink CR procedure, the hippocampus is also necessary f...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0014263

    authors: Pakaprot N,Kim S,Thompson RF

    更新日期:2009-02-01 00:00:00

  • Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of rats.

    abstract::In male rats with food and water freely available, the specific dopamine D2 antagonist YM-09151-2 had little effect on total food or water intake across a 24-hr period. However, it produced a substantial dose-related decrease in feeding rate during meals and an enhancement of both meal size and duration. The equivalen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.2.272

    authors: Clifton PG,Rusk IN,Cooper SJ

    更新日期:1991-04-01 00:00:00

  • Environmental enrichment as a therapy for autism: A clinical trial replication and extension.

    abstract::Based on work done in animal models showing that autism-like symptoms are ameliorated following exposure to an enriched sensorimotor environment, we attempted to develop a comparable therapy for children with autism. In an initial randomized controlled trial, children with autism who received sensorimotor enrichment a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/bne0000068

    authors: Woo CC,Donnelly JH,Steinberg-Epstein R,Leon M

    更新日期:2015-08-01 00:00:00

  • Functional recovery of taste sensitivity to sodium chloride depends on regeneration of the chorda tympani nerve after transection in the rat.

    abstract::Chorda tympani nerve (CT) transection (CTX) raises sodium chloride (NaCl) taste detection threshold, but the effect of CT regeneration on NaCl threshold is unknown. This experiment examined whether CT regeneration supports normal NaCl threshold in the rat. Thresholds were measured with a 2-lever operant procedure. Thr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Kopka SL,Spector AC

    更新日期:2001-10-01 00:00:00

  • The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference.

    abstract::There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0036964

    authors: Shen F,Wang N,Qi C,Li YJ,Cui CL

    更新日期:2014-08-01 00:00:00

  • Adult rats stressed as neonates show exaggerated behavioral responses to both pharmacological and environmental challenges.

    abstract::Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.112.1.116

    authors: Kehoe P,Shoemaker WJ,Triano L,Callahan M,Rappolt G

    更新日期:1998-02-01 00:00:00

  • Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

    abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026461

    authors: Chisholm NC,Juraska JM

    更新日期:2012-02-01 00:00:00

  • Dopaminergic activity modulation via aggression, status, and a visual social signal.

    abstract::Social interaction may elicit aggression, establish social rank, and be influenced by changes in central dopaminergic activity. In the lizard Anolis carolinensis, a sign stimulus (darkening of postorbital skin or eyespots) inhibits aggressive response from opponents, in part because it forms more rapidly in dominant m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.1.93

    authors: Korzan WJ,Forster GL,Watt MJ,Summers CH

    更新日期:2006-02-01 00:00:00

  • Modulation of memory consolidation for olfactory learning by reversible inactivation of the basolateral amygdala.

    abstract::The role of the basolateral amygdala (BLA) in the consolidation of an association between an olfactory stimulus and footshock was investigated with a reversible lesion technique of post-training intra-BLA infusions of tetrodotoxin. Rats receiving tetrodotoxin infusions following paired odor-shock presentations spent m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.117.1.184

    authors: Kilpatrick L,Cahill L

    更新日期:2003-02-01 00:00:00

  • Configurational and nonconfigurational interactions between odorants in binary mixtures.

    abstract::Studies on odor mixture perception suggest that although odor components can often be identified in mixtures, mixtures can also give rise to novel perceptual qualities that are not present in the components. Using an olfactory habituation task, the authors evaluated how the perceptual similarity between components in ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.117.2.236

    authors: Wiltrout C,Dogra S,Linster C

    更新日期:2003-04-01 00:00:00

  • An accessory sex gland aggression-promoting chemosignal in male mice.

    abstract::The present study investigated male murine accessory sex glands as potential sources of a urinary aggression-promoting chemosignal. Experiments 1-4 were designed to determine whether the removal of the following glands would eliminate voided urine chemosignal activity: vesicular and coagulating glands, Cowper's gland,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.5.777

    authors: Ingersoll DW,Morley KT,Benvenga M,Hands C

    更新日期:1986-10-01 00:00:00

  • Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.

    abstract::Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta-agonist, isoproterenol, or the alpha1-agonist, phen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.115.1.165

    authors: Berridge CW,O'Neill J

    更新日期:2001-02-01 00:00:00

  • Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

    abstract::The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disorders and schizophrenia. However, the link between α-neurexin deficien...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000108

    authors: Dachtler J,Ivorra JL,Rowland TE,Lever C,Rodgers RJ,Clapcote SJ

    更新日期:2015-12-01 00:00:00

  • A peripheral, intracerebral, or intrathecal administration of an opioid receptor antagonist blocks illness-induced hyperalgesia in the rat.

    abstract::We used the tail-flick response of rats to study the role of opioid receptors in illness-induced hyperalgesia. An intraperitoneal injection of lithium chloride (LiCl) produced hyperalgesia that was blocked in a dose-dependent manner by subcutaneous injection of the opioid antagonist naloxone. Neither hyperalgesia nor ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.114.6.1183

    authors: McNally GP,Johnston IN,Westbrook RF

    更新日期:2000-12-01 00:00:00

  • The ontogeny of human learning in delay, long-delay, and trace eyeblink conditioning.

    abstract::The ontogeny of associative learning in delay (750-ms conditional stimulus [CS], 650-ms interstimulus interval [ISI]), long-delay (1,350-ms CS, 1,250-ms ISI), and trace (750-ms CS, 500-ms trace interval, 1,250-ms ISI) eyeblink conditioning was examined in 5-month-old human infants and adults. Infants and adults showed...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1037/0735-7044.117.6.1196

    authors: Herbert JS,Eckerman CO,Stanton ME

    更新日期:2003-12-01 00:00:00