Abstract:
:We used the tail-flick response of rats to study the role of opioid receptors in illness-induced hyperalgesia. An intraperitoneal injection of lithium chloride (LiCl) produced hyperalgesia that was blocked in a dose-dependent manner by subcutaneous injection of the opioid antagonist naloxone. Neither hyperalgesia nor its blockade by naloxone were due to variations in tail-skin temperature induced by LiCl. Hyperalgesia was also blocked when opioid receptor antagonism was restricted to (a) the periphery, by intraperitoneal administration of the quaternary opioid receptor antagonist naloxone methiodide; (b) the brain, by intracerebroventricular microinjection of naloxone; or (c) the spinal cord, by intrathecal microinjection of naloxone. These results document a pain facilitatory role of opioid receptors in both the peripheral and central nervous systems and are discussed with reference to their analgesic and motivational functions.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
McNally GP,Johnston IN,Westbrook RFdoi
10.1037//0735-7044.114.6.1183subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1183-90issue
6eissn
0735-7044issn
1939-0084journal_volume
114pub_type
杂志文章abstract::Two groups of rats were trained on operant discriminations in which the discriminanda were two different sound pressure levels of a 4-kHz tone. The discriminanda were chosen so that the loudness difference between stimuli was equivalent for each group when calculated from a power function with an exponent of .35. Half...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.97.3.392
更新日期:1983-06-01 00:00:00
abstract::This study examined the effects of intense emotional learning on the sleep-wake state-specific electroencephalographic (EEG) activities of the basolateral (BLA) and central (CeA) nuclei of the amygdala. Rats were trained on a passive-avoidance learning (PAL) protocol that was followed by 6 hr of undisturbed polygraphi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.117.4.751
更新日期:2003-08-01 00:00:00
abstract::Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmen...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.1.116
更新日期:1998-02-01 00:00:00
abstract::Plasma corticosterone levels were evaluated during operant conditioning in order to determine the effect of reinforced and nonreinforced responding (extinction) on adrenal activation. The influence of instrumental responding was assessed by comparing trained rats with yoked subjects that received a matched reward sche...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.97.4.654
更新日期:1983-08-01 00:00:00
abstract::Ovariectomized female rats treated with estradiol benzoate (EB) and progesterone (P) were infused intracerebroventricularly with a low (200 ng) or high (1 microgram) dose of oxytocin (OT). The low dose of OT facilitated lordosis behavior only during the dark phase of the light-dark cycle in females that were pretreate...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.3.487
更新日期:1991-06-01 00:00:00
abstract::This study investigated the effect of postnatal tactile stimulation (TS) on juvenile behavior, adult amphetamine (AMPH) sensitization, and the interaction of TS and AMPH on prefrontal cortical (PFC) thickness and striatum size. Pups received TS by stroking daily with a feather duster from birth till weaning and were t...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0022628
更新日期:2011-04-01 00:00:00
abstract::A very high correlation was found in rats between latency to escape on the first trial of an active avoidance task and the rate at which [leu]enkephalin is hydrolyzed in plasma. In addition, the rate of [leu]enkephalin hydrolysis is significantly altered following the first training trial. The results suggest that a r...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.3.404
更新日期:1988-06-01 00:00:00
abstract::Animals and humans are able to predict and synchronize their daily activity to signals present in their environments. Environmental cues are most often associated with signaling the beginning or the end of a daily activity cycle, but they can also be used to time the presentation or availability of scarce resources. I...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0017128
更新日期:2009-10-01 00:00:00
abstract::These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.4.730
更新日期:2004-08-01 00:00:00
abstract::Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.100.4.483
更新日期:1986-08-01 00:00:00
abstract::The role of the hippocampus in associative learning was investigated in 3 experiments with rats as subjects. Hippocampal rats were impaired in the acquisition of conditioned responding both when food was signaled by the insertion of a lever (Experiment 1) and when the presentation of auditory or visual events served a...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.105.4.499
更新日期:1991-08-01 00:00:00
abstract::Gerbils aged 3 months and 24+ months were subjected to 5 min of global forebrain ischemia and tested in a radial arm maze (1 trial/day, 50 days). Compared with age-matched, sham-operated controls, ischemic animals were impaired on measures of both working and reference memory. Aged animals were impaired on working mem...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.4.937
更新日期:1998-08-01 00:00:00
abstract::Novelty seeking refers to the tendency of humans and animals to explore novel and unfamiliar stimuli and environments. The idea that dopamine modulates novelty seeking is supported by evidence that novel stimuli excite dopamine neurons and activate brain regions receiving dopaminergic input. In addition, dopamine is s...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0037128
更新日期:2014-10-01 00:00:00
abstract::Four rhesus monkeys (Macaca mulatta) were trained to learn novel sets of visuomotor associations in 50 trials or less, within single test sessions. After bilateral ablation of the orbital and ventral prefrontal cortex, the monkeys lost the ability to learn these associations within a session, although they could learn...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.115.5.971
更新日期:2001-10-01 00:00:00
abstract::The gustatory rejection response of the cabbage looper, Trichoplusia ni (Lepidoptera: Noctuidae), habituates to antifeedant compounds, allowing for the consumption of deterrent yet nontoxic plant materials. In the present study, we demonstrate that habituation to an antifeedant compound (quinine) persists through the ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0020741
更新日期:2010-10-01 00:00:00
abstract::This study was performed with male rats categorized as sexually naive (SN), sexually active (SA), or sexually inactive (SI). In a first experiment the effects of dopamine (DA) D2 agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA and SI rats were assessed. In a second experiment the DA D2 ago...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.4.802
更新日期:1996-08-01 00:00:00
abstract::The purpose of the present study was to explore the lasting effects of a tactile sensitivity enhancement induced by spike insoles on the control of stance in the elderly. Healthy elderly subjects (n = 19, mean age = 68.8) and young adults (n = 17, mean age = 24.3) were instructed to stand or to walk for 5 minutes with...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0017115
更新日期:2009-10-01 00:00:00
abstract::Rats received kindling stimulations to the perirhinal cortex (PRh), ventral hippocampus (VH), or dorsal hippocampus (DH) in 1 environment and an equivalent number of sham stimulations in a 2nd environment. The PRh-kindled rats displayed rapid kindling and a swift emergence of conditioned interictal defensiveness. In c...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.6.1572
更新日期:2005-12-01 00:00:00
abstract::Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.112.5.1125
更新日期:1998-10-01 00:00:00
abstract::Relations between sleep and memory were examined as a function of aging in rats. Sleep (24 hr), passive avoidance retention, and choline acetyltransferase (CAT) activity were assessed in 3 age-groups (6, 15, and 24 months old). Age-related alterations were evident in sleep, memory, and cortical and striatal CAT activi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.4.755
更新日期:1989-08-01 00:00:00
abstract::Dopamine (DA)-containing neurons in the ventral tegmental area (VTA) are thought to play an important role in fear motivation. The primary objective of the present study was to determine the connection between DA D2, gamma aminobutyric acid (GABA)A, and benzodiazepine receptors in the VTA and footshock-associated emot...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Hindlimb flexion induced by direct stimulation of the hindlimb has been observed subsequent to spinal section if an appropriate time interval was allowed to elapse between onset of flexion and spinal cord section. The present series of experiments was conducted to test the possibility that asymmetry persistence is a p...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.97.6.921
更新日期:1983-12-01 00:00:00
abstract::Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairings to early acquisition (consolidation) or well trained (over...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.5.935
更新日期:1989-10-01 00:00:00
abstract::Contradictory results are found in the literature concerning the role of vision in the perception of space or in spatial navigation, in part because of the lack of murine models of total blindness used so far. The authors evaluated the spatial abilities of anophthalmic transgenic mice. These mice did not differ qualit...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::In humans and some nonhuman vertebrates, a sound containing brief silent gaps can be rendered perceptually continuous by inserting noise into the gaps. This so-called "continuity illusion" arises from a phenomenon known as "auditory induction" and results in the perception of complete auditory objects despite fragment...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000115
更新日期:2016-02-01 00:00:00
abstract::Chorda tympani nerve (CT) transection in rats severely impairs NaCl taste detection. These rats can detect higher concentrations of NaCl, however, suggesting that remaining oral nerves maintain some salt sensibility. Rats were tested in a gustometer with a 2-response operant taste-detection task before and after sham ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.120.3.580
更新日期:2006-06-01 00:00:00
abstract::The female steroid hormone 17beta-estradiol enhances synaptic transmission and the magnitude of longterm potentiation (LTP) in adult rodent hippocampal slices. Long-term depression (LTD), another form of synaptic plasticity, occurs more prominently in hippocampal slices from aged rodents. A decrease in LTP has been re...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.122.2.301
更新日期:2008-04-01 00:00:00
abstract::There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0036964
更新日期:2014-08-01 00:00:00
abstract::Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the authors examined behavior (social and ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000220
更新日期:2017-12-01 00:00:00
abstract::Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.2.331
更新日期:1996-04-01 00:00:00