A peripheral, intracerebral, or intrathecal administration of an opioid receptor antagonist blocks illness-induced hyperalgesia in the rat.


:We used the tail-flick response of rats to study the role of opioid receptors in illness-induced hyperalgesia. An intraperitoneal injection of lithium chloride (LiCl) produced hyperalgesia that was blocked in a dose-dependent manner by subcutaneous injection of the opioid antagonist naloxone. Neither hyperalgesia nor its blockade by naloxone were due to variations in tail-skin temperature induced by LiCl. Hyperalgesia was also blocked when opioid receptor antagonism was restricted to (a) the periphery, by intraperitoneal administration of the quaternary opioid receptor antagonist naloxone methiodide; (b) the brain, by intracerebroventricular microinjection of naloxone; or (c) the spinal cord, by intrathecal microinjection of naloxone. These results document a pain facilitatory role of opioid receptors in both the peripheral and central nervous systems and are discussed with reference to their analgesic and motivational functions.


Behav Neurosci


Behavioral neuroscience


McNally GP,Johnston IN,Westbrook RF




Has Abstract


2000-12-01 00:00:00












  • Mapping the substrate for brain stimulation reward by means of current-number trade-off functions.

    abstract::In previous studies using moveable electrodes to map the substrate for brain stimulation reward, reward effectiveness was estimated by varying either the current or the number of pulses per train. The resulting relationship between reward effectiveness and stimulation site is independent of the fixed parameter only if...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Forgie ML,Shizgal P

    更新日期:1993-06-01 00:00:00

  • Opioid action on response level to a danger stimulus in the crab (Chasmagnathus granulatus).

    abstract::When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the response to a dang...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Maldonado H,Romano A,Lozada M

    更新日期:1989-10-01 00:00:00

  • Click-evoked otoacoustic emissions: response amplitude is associated with circulating testosterone levels in men.

    abstract::In rhesus monkeys, the magnitude of the cochlear response to auditory stimuli (click-evoked otoacoustic emissions, [CEOAEs]) is correlated with seasonal changes in circulating testosterone levels. The present study investigated the association between circulating testosterone and CEOAE production in men. CEOAEs were m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Snihur AW,Hampson E

    更新日期:2012-04-01 00:00:00

  • Tactile stimulation during development attenuates amphetamine sensitization and structurally reorganizes prefrontal cortex and striatum in a sex-dependent manner.

    abstract::This study investigated the effect of postnatal tactile stimulation (TS) on juvenile behavior, adult amphetamine (AMPH) sensitization, and the interaction of TS and AMPH on prefrontal cortical (PFC) thickness and striatum size. Pups received TS by stroking daily with a feather duster from birth till weaning and were t...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Muhammad A,Hossain S,Pellis SM,Kolb B

    更新日期:2011-04-01 00:00:00

  • Nonlinear temporal integration of brain stimulation reward.

    abstract::A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, altho...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Hawkins RD

    更新日期:2011-12-01 00:00:00

  • Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).

    abstract::Female songbirds use male songs as an important criterion for mate selection. Several studies have reported that female songbirds prefer complex songs to other song types. In a recent study, the authors found that song responsiveness in female zebra finches (Taeniopygia guttata) is strongly modulated by circulating es...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Vyas A,Harding C,McGowan J,Snare R,Bogdan D

    更新日期:2008-10-01 00:00:00

  • Selective immunotoxic lesions of basal forebrain cholinergic neurons: twenty years of research and new directions.

    abstract::The advent of the selective cholinergic toxin, 192 IgG-saporin, dramatically shaped subsequent research on the role of the basal forebrain in learning and memory. In particular, several articles (including the authors' 1995 Behavioral Neuroscience paper; M. G. Baxter, D. J. Bucci, L. K., Gorman, R. G. Wiley, & M. Gall...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Baxter MG,Bucci DJ

    更新日期:2013-10-01 00:00:00

  • Overt orienting in the rat: parametric studies of cued detection of visual targets.

    abstract::Covert shifts of visual attention in space have been quantified by measuring the effects of visual cues on the detection of visual targets in humans and monkeys maintaining visual fixation. These observations of "covert orienting" have provided important information regarding the neurobiology of visual attention in pr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Bushnell PJ

    更新日期:1995-12-01 00:00:00

  • Neonatal hind-paw injury disrupts acquisition of an instrumental response in adult spinal rats.

    abstract::The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Young EE,Baumbauer KM,Elliot A,Joynes RL

    更新日期:2007-10-01 00:00:00

  • What does a pigeon (Columba livia) brain look like during homing? selective examination of ZENK expression.

    abstract::Lesion studies have shown that the avian hippocampus plays a crucial role in homing pigeon (Columba livia) navigation. Using the expression of the immediate early gene protein ZENK in intact pigeons, the authors found regional variation in hippocampal activation as a consequence of homing and, necessarily, the behavio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Shimizu T,Bowers AN,Budzynski CA,Kahn MC,Bingman VP

    更新日期:2004-08-01 00:00:00

  • Behavioral sensitization to apomorphine in pigeons (Columba livia): blockade by the D1 dopamine antagonist SCH-23390.

    abstract::Repeated administration of apomorphine leads to a context-dependent pecking response sensitization. Previously sensitized pigeons (Columba livia) challenged with saline in the same context show a conditioned response (CR). The authors studied the effects of intrastriatal injections of the dopamine (D(1)) antagonist SC...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Acerbo MJ,Delius JD

    更新日期:2004-10-01 00:00:00

  • Does shape matter? Theoretical comment on Jones, Pearce, Davies, Good, and McGregor (2007).

    abstract::An influential view in the field of spatial cognition is that an obligatory geometric module constrains spatial learning and memory. In this issue, P. M. Jones, J. M. Pearce, V. J. Davies, M. A. Good, and A. McGregor (2007) showed that learning based on the geometry, or shape, of the environment requires the hippocamp...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Dudchenko PA

    更新日期:2007-12-01 00:00:00

  • Delayed spontaneous alternation in intact and cerebellectomized control and lurcher mutant mice: differential role of cerebellar cortex and deep cerebellar nuclei.

    abstract::Lurcher mutant (+/Lc) mice exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nucleus while deep cerebellar nuclei are essentially intact. To discriminate the respective participation of the cerebellar cortex and deep structures in learning and memory, the authors subjected 3- to 6-...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Caston J,Vasseur F,Delhaye-Bouchaud N,Mariani J

    更新日期:1997-02-01 00:00:00

  • Effects of exposure to stressors of varying predictability on adrenal function in rats.

    abstract::For 5 days, rats were exposed to shocks that were signalled by a light 0, 33, 66, or 100% of the time. Basal hormone levels and responses to a light-shock pair were measured daily. Greater predictability was associated with higher basal plasma corticosterone and norepinephrine levels indicative of chronic stress. Habi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pitman DL,Natelson BH,Ottenweller JE,McCarty R,Pritzel T,Tapp WN

    更新日期:1995-08-01 00:00:00

  • L-DOPA and quipazine elicit air-stepping in neonatal rats with spinal cord transections.

    abstract::Acute mid-thoracic spinal cord transection eliminates hindlimb air-stepping in neonatal rats suspended in harnesses and administered L-DOPA. Because spinal cord transection eliminates all descending inputs to the hindlimb locomotor circuits, this experiment determined if coadministration of L-DOPA and quipazine (serot...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: McEwen ML,Van Hartesveldt C,Stehouwer DJ

    更新日期:1997-08-01 00:00:00

  • Pattern of [14C]2-deoxyglucose concentration associated with potentiation of reproductive behavior by prostaglandin E2.

    abstract::One indication of receptive behavior of the female leopard frog, Rana pipiens, is absence of a release call during tactile stimulation of the trunk. Prostaglandin E2 (PGE2) inhibits this call. This experiment demonstrates a different pattern of [14C]2-deoxyglucose concentration in brains of 5 receptive females silence...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Diakow C,Woicyk W,McEachron DL,Adler NT

    更新日期:1989-10-01 00:00:00

  • Associative retuning in the thalamic source of input to the amygdala and auditory cortex: receptive field plasticity in the medial division of the medial geniculate body.

    abstract::The medial division of the medial geniculate body (MGm) projects to the lateral amygdala and the upper layer of auditory cortex and develops physiological plasticity rapidly during classical conditioning. The effects of learning on frequency receptive fields (RFs) in the MGm of the guinea pig have been determined. Cla...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Edeline JM,Weinberger NM

    更新日期:1992-02-01 00:00:00

  • Dissociable properties of memory systems: differences in the flexibility of declarative and nondeclarative knowledge.

    abstract::Amnesic patients (n = 8), who have severely impaired declarative memory, learned a probabilistic classification task at the same rate as normal subjects (n = 16) but subsequently were impaired on transfer tests that required flexible use of their task knowledge. A second group of controls (n = 20) rated the questions ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Reber PJ,Knowlton BJ,Squire LR

    更新日期:1996-10-01 00:00:00

  • The role of hippocampal regions CA3 and CA1 in matching entorhinal input with retrieval of associations between objects and context: theoretical comment on Lee et al. (2005).

    abstract::Models of hippocampal function have proposed different functions for hippocampal regions CA3 and CA1, commonly proposing that CA1 performs a match-mismatch comparison of memory retrieval with sensory input. The study by I. Lee, M. R. Hunsaker, and R. P. Kesner (2005) tested these models using selective lesions of hipp...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章


    authors: Hasselmo ME

    更新日期:2005-02-01 00:00:00

  • Long-term effects of leucine-enkephalin on active avoidance responding in mice.

    abstract::The effects of peripherally administered leucine-enkephalin on the acquisition and retention of active avoidance behavior was studied in mice. Mice received 4 training trials on Day 1, 24 test trials on Day 2, and 10 test trials on Day 5. Leucine-enkephalin impaired the aquisition of avoidance behavior when administer...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dana RC,Martinez JL Jr

    更新日期:1986-04-01 00:00:00

  • The role of hippocampal subregions in detecting spatial novelty.

    abstract::Previous literature suggests that the hippocampus subserves processes associated with the encoding of novel information. To investigate the role of different subregions of the hippocampus, the authors made neurotoxic lesions in different subregions of the dorsal hippocampus (i.e., CA1, dentate gyrus [DG], or CA3) of r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lee I,Hunsaker MR,Kesner RP

    更新日期:2005-02-01 00:00:00

  • Sustained attention in the mouse: a study of the relationship with the cerebellum.

    abstract::To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Martin LA,Goldowitz D,Mittleman G

    更新日期:2006-04-01 00:00:00

  • Behavior of rat fetuses following chemical or tactile stimulation.

    abstract::The behavior of fetal rats was examined on Day 19 of gestation with procedures that enabled chemical stimulation and direct observation of fetuses. Rat fetuses are sensitive to both tactile stroking and intraoral infusion of chemical solutions, but the pattern and amount of activity depend upon the modality of stimula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Smotherman WP,Robinson SR

    更新日期:1988-02-01 00:00:00

  • The role of central amygdala dopamine in disengagement behavior.

    abstract::Unilateral nigrostriatal dopamine depletion in animals induces contralateral sensorimotor deficits that are like symptoms associated with Parkinson's disease (PD). Unilateral nigrostriatal dopamine depletion also causes a contralateral deficit in disengagement behavior (e.g., ability to stop an ongoing activity to ori...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Smith ES,Geissler SA,Schallert T,Lee HJ

    更新日期:2013-04-01 00:00:00

  • Central nervous system regulation of finicky feeding by the blowfly.

    abstract::Finicky feeding refers to an animal's tendency to become more particular in accepting and choosing food as satiation is approached. We tested the hypothesis that finickiness in the blowfly is related to the balance between internal inhibition, generated by a full crop, and external sensory information, generated by or...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Moss CF,Dethier VG

    更新日期:1983-08-01 00:00:00

  • Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

    abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

    更新日期:2009-08-01 00:00:00

  • Attenuation of cycloheximide-induced amnesia in mice with strychnine sulfate.

    abstract::Two experiments were conducted to determine the effectiveness of strychnine sulfate in attenuating the amnesia induced in mice by small doses of cycloheximide (CYC). Previously, reversal of CYC-induced amnesia catecholamine agonists has been taken as evidence that protein synthesis inhibitors induce amnesia via an inh...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Leccese AP,Quinton EE

    更新日期:1983-04-01 00:00:00

  • Behavioral depression during cocaine withdrawal is associated with decreased spontaneous activity of ventral tegmental area dopamine neurons.

    abstract::Withdrawal from an escalating-dose, bingelike regimen of cocaine administration in rats produced significantly depressed levels of locomotor activity during the nocturnal portion of the day-night cycle. This effect was observed during the first 48 hr of testing. Extracellular single-unit recordings of ventral tegmenta...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Koeltzow TE,White FJ

    更新日期:2003-08-01 00:00:00

  • The union of the state: myoclonic twitching is coupled with nuchal muscle atonia in infant rats.

    abstract::Active sleep (AS), as measured by the occurrence of myoclonic twitching (MT), is the most prevalent behavioral state in newborn rats. Historically, AS has been considered a developmental precursor of REM sleep, but recently this idea has been questioned. In the present study, the authors assess, in 2-, 5-, and 8-day-o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Karlsson KA,Blumberg MS

    更新日期:2002-10-01 00:00:00

  • Neonatal hypoxia-ischemia induces attention-deficit hyperactivity disorder-like behavior in rats.

    abstract::Attention-deficit hyperactivity disorder (ADHD) may be caused by genetic or environmental factors. Among environmental factors, perinatal complications are related, such as neonatal hypoxia-ischemia (HI). Thus, the aim of this study was to investigate whether HI contributes to the development of characteristics relate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Miguel PM,Schuch CP,Rojas JJ,Carletti JV,Deckmann I,Martinato LH,Pires AV,Bizarro L,Pereira LO

    更新日期:2015-06-01 00:00:00