Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits.

Abstract:

:Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairings to early acquisition (consolidation) or well trained (overtraining); retention was tested. Two effects were observed: 1) Rabbits with hippocampal lesions showed less retention in the consolidation experiment than controls. Previous studies may not have found this because initial training was more complete. Overtrained hippocampal rabbits showed more retention, which agrees with this suggestion. 2) Hippocampectomized rabbits showed larger CR amplitudes in the overtraining experiment. The complementary roles of hippocampus in the consolidation process during early learning and in modulating the expression of the amplitude/time course of behavioral conditioned responses after associations are well learned are discussed.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Akase E,Alkon DL,Disterhoft JF

doi

10.1037//0735-7044.103.5.935

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

935-43

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

103

pub_type

杂志文章
  • Pineal transplantation to the brain of pinealectomized lizards: effects on circadian rhythms of locomotor activity.

    abstract::Pinealectomized lizards (Podarcis sicula) whose locomotor rhythms were recorded in constant temperature (29 degrees C) and darkness were subdivided into 2 groups of hosts: Each belonging to the 1st group (experimentals) received from a donor a pineal gland, and each belonging to the 2nd one (controls) received a piece...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.5.1123

    authors: Foà A,Bertolucci C,Marsanich A,Innocenti A

    更新日期:1997-10-01 00:00:00

  • Olfactory associative learning in Caenorhabditis elegans is impaired in lrn-1 and lrn-2 mutants.

    abstract::The C. elegans mutants, lrn-1 and lrn-2, are impaired in associative learning using conditioned taste cues. Both mutants are defective in associative learning about appetitive and aversive events, indicating that lrn-1 and lrn-2 exert effects across motivational boundaries. In a new olfactory associative learning para...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.2.358

    authors: Morrison GE,Wen JY,Runciman S,van der Kooy D

    更新日期:1999-04-01 00:00:00

  • Effects of hydrocortisone on false memory recognition in healthy men and women.

    abstract::Most of the studies focusing on the effect of stress on false memories by using psychosocial and physiological stressors yielded diverse results. In the present study, we systematically tested the effect of exogenous hydrocortisone using a false memory paradigm. In this placebo-controlled study, 37 healthy men and 38 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000170

    authors: Duesenberg M,Weber J,Schaeuffele C,Fleischer J,Hellmann-Regen J,Roepke S,Moritz S,Otte C,Wingenfeld K

    更新日期:2016-12-01 00:00:00

  • Selective immunotoxic lesions of basal forebrain cholinergic neurons: twenty years of research and new directions.

    abstract::The advent of the selective cholinergic toxin, 192 IgG-saporin, dramatically shaped subsequent research on the role of the basal forebrain in learning and memory. In particular, several articles (including the authors' 1995 Behavioral Neuroscience paper; M. G. Baxter, D. J. Bucci, L. K., Gorman, R. G. Wiley, & M. Gall...

    journal_title:Behavioral neuroscience

    pub_type: 评论,杂志文章

    doi:10.1037/a0033781

    authors: Baxter MG,Bucci DJ

    更新日期:2013-10-01 00:00:00

  • Auditory streaming by phase relations between components of harmonic complexes: a comparative study of human subjects and bird forebrain neurons.

    abstract::Auditory streaming describes a percept in which a sequential series of sounds either is segregated into different streams or is integrated into one stream based on differences in their spectral or temporal characteristics. This phenomenon has been analyzed in human subjects (psychophysics) and European starlings (neur...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0030249

    authors: Dolležal LV,Itatani N,Günther S,Klump GM

    更新日期:2012-12-01 00:00:00

  • Muscarinic cholinergic neuromodulation reduces proactive interference between stored odor memories during associative learning in rats.

    abstract::Previous electrophysiological studies and computational modeling suggest the hypothesis that cholinergic neuromodulation may reduce olfactory associative interference during learning (M. E. Hasselmo, B. P. Anderson, & J. M. Bower, 1992; M. E. Hasselmo & J. M. Bower, 1993). These results provide behavioral evidence sup...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: De Rosa E,Hasselmo ME

    更新日期:2000-02-01 00:00:00

  • Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory.

    abstract::Preadolescent mice have been shown to be differentially susceptible to the effects of both acute and chronic nicotine exposure on contextual fear learning relative to adults. For this study, we tested the effects of chronic nicotine exposure in preadolescence on adulthood extinction and spontaneous recovery of fear me...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000247

    authors: Zeid D,Gould TJ

    更新日期:2018-08-01 00:00:00

  • Dietary self-selection in intact, ovariectomized, and estradiol-treated female rats.

    abstract::The effects of estrogenic stimulation on diet selection were examined in intact, estrous cycling rats, ovariectomized (OVX) rats, and OVX rats given estradiol benzoate (EB) hormone replacement therapy. In Experiment 1, OVX was associated with the nearly exclusive choice of the more calorically dense diet of a pair of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.1.125

    authors: Bartness TJ,Waldbillig RJ

    更新日期:1984-02-01 00:00:00

  • Does intranasal application of zinc sulfate produce anosmia in the rat?

    abstract::Transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from olfactory sensory neurons to the olfactory bulb as well as odor detection and discrimination were examined in rats in which each nasal epithelium had been irrigated with 0.1-0.5 ml 5% zinc sulfate. After treatment, rats showed few or no deficits ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:

    authors: Slotnick B,Glover P,Bodyak N

    更新日期:2000-08-01 00:00:00

  • Stress and adenosine: II. Adenosine analogs mimic the effect of inescapable shock on shuttle-escape performance in rats.

    abstract::In 3 experiments, the authors examined the role of adenosine regulation in escape deficits produced by earlier exposure to inescapable shock in rats (learned helplessness). Adenosine analogs injected before escape testing mimicked the effect of earlier inescapable shock, with the magnitude of the deficit varying with ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.108.2.265

    authors: Minor TR,Winslow JL,Chang WC

    更新日期:1994-04-01 00:00:00

  • Fimbria-fornix transections disrupt the ontogeny of delayed alternation but not position discrimination in the rat.

    abstract::In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the P...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.3.386

    authors: Freeman JH Jr,Stanton ME

    更新日期:1991-06-01 00:00:00

  • Effect of social isolation on anxiety-related behaviors, cortisol, and monoamines in adult zebrafish.

    abstract::Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the authors examined behavior (social and ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000220

    authors: Shams S,Seguin D,Facciol A,Chatterjee D,Gerlai R

    更新日期:2017-12-01 00:00:00

  • Central dopamine turnover in guinea pig pups during separation from their mothers in a novel environment.

    abstract::Guinea pig pups that were separated from their mothers and placed into a novel environment for 90 min showed an increase in dopamine (DA) turnover (ratio of metabolites to DA) in the septum compared with undisturbed baseline controls. Pups placed into the novel environment with their mothers exhibited an intermediate ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.104.4.607

    authors: Tamborski A,Lucot JB,Hennessy MB

    更新日期:1990-08-01 00:00:00

  • Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster).

    abstract::Male prairie voles (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP V1a receptor antagonist in the lateral se...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.115.4.910

    authors: Liu Y,Curtis JT,Wang Z

    更新日期:2001-08-01 00:00:00

  • Neuron production, neuron number, and structure size are seasonally stable in the hippocampus of the food-storing black-capped chickadee (Poecile atricapillus).

    abstract::Neuronal recruitment in the black-capped chickadee (Poecile atricapillus) hippocampus occurs at a higher rate in the fall than at other times of the year. As a means of determining whether this increase in recruitment results from greater neuron production, chickadees were caught in the wild between October and March ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.2.345

    authors: Hoshooley JS,Sherry DF

    更新日期:2004-04-01 00:00:00

  • Noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4), treatment eliminates estrogenic effects on song responsiveness in female zebra finches (Taeniopygia guttata).

    abstract::Female songbirds use male songs as an important criterion for mate selection. Several studies have reported that female songbirds prefer complex songs to other song types. In a recent study, the authors found that song responsiveness in female zebra finches (Taeniopygia guttata) is strongly modulated by circulating es...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.5.1148

    authors: Vyas A,Harding C,McGowan J,Snare R,Bogdan D

    更新日期:2008-10-01 00:00:00

  • Fixation of spinal reflex alterations in spinal rats by sensory nerve stimulation.

    abstract::Two preparations in which sensory nerve stimulation was used to obtain peripherally induced spinal fixation in spinal rats are described. In the first preparation, proportionally greater amounts of persisting poststimulation flexor muscle contraction, as measured by a force displacement transducer, were produced as st...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/h0092460

    authors: Steinmetz JE,Patterson MM

    更新日期:1985-02-01 00:00:00

  • Androgens and imprinting: differential effects of testosterone on filial preference in the domestic chick.

    abstract::The relation between testosterone and imprinting was investigated in domestic chicks. After hatching, chicks received either testosterone enanthate in oil or oil alone (controls). The chicks were then trained by exposing them to a rotating imprinting stimulus, either a red box or a stuffed jungle fowl. A preference sc...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.100.1.51

    authors: Bolhuis JJ,McCabe BJ,Horn G

    更新日期:1986-02-01 00:00:00

  • Morphine influences on classical aversive conditioned heart rate in rats.

    abstract::The present series of three experiments was concerned with the effects of morphine and the morphine antagonist naloxone on the development of a classical aversive heart rate (HR) conditioned response (CR) to a tone conditioned stimulus (CS) paired with an electric shock unconditioned stimulus (US). In the first study,...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.2.244

    authors: Mahalik T,Fitzgerald RD

    更新日期:1988-04-01 00:00:00

  • Behavioral effects of methylazoxymethanol-induced micrencephaly.

    abstract::This study was prompted by reports of functionally normal humans with micrencephaly or cortical hypoplasia. Methylazoxymethanol acetate (MAM) treatment, which induces micrencephaly in rats, was administered by injection (20 mg/kg) on gestational day 14. Prior to weaning and into adulthood, offspring were assessed on m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.107.6.1067

    authors: Ferguson SA,Racey FD,Paule MG,Holson RR

    更新日期:1993-12-01 00:00:00

  • Associative retuning in the thalamic source of input to the amygdala and auditory cortex: receptive field plasticity in the medial division of the medial geniculate body.

    abstract::The medial division of the medial geniculate body (MGm) projects to the lateral amygdala and the upper layer of auditory cortex and develops physiological plasticity rapidly during classical conditioning. The effects of learning on frequency receptive fields (RFs) in the MGm of the guinea pig have been determined. Cla...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.1.81

    authors: Edeline JM,Weinberger NM

    更新日期:1992-02-01 00:00:00

  • 17beta-estradiol modifies stress-induced and age-related changes in hippocampal synaptic plasticity.

    abstract::The female steroid hormone 17beta-estradiol enhances synaptic transmission and the magnitude of longterm potentiation (LTP) in adult rodent hippocampal slices. Long-term depression (LTD), another form of synaptic plasticity, occurs more prominently in hippocampal slices from aged rodents. A decrease in LTP has been re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.122.2.301

    authors: Foy MR,Baudry M,Foy JG,Thompson RF

    更新日期:2008-04-01 00:00:00

  • Effects of postretrieval-extinction learning on return of contextually controlled cued fear.

    abstract::Reactivation of an already consolidated memory makes it labile for a period of several hrs, which are required for its reconsolidation. Evidence suggests that the return of conditioned fear through spontaneous recovery, reinstatement, or renewal can be prevented by blockading this reconsolidation process using pharmac...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0036688

    authors: Meir Drexler S,Merz CJ,Hamacher-Dang TC,Marquardt V,Fritsch N,Otto T,Wolf OT

    更新日期:2014-08-01 00:00:00

  • The impact of napping on memory for future-relevant stimuli: Prioritization among multiple salience cues.

    abstract::Prior research has demonstrated that sleep enhances memory for future-relevant information, including memory for information that is salient due to emotion, reward, or knowledge of a later memory test. Although sleep has been shown to prioritize information with any of these characteristics, the present study investig...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000142

    authors: Bennion KA,Payne JD,Kensinger EA

    更新日期:2016-06-01 00:00:00

  • Effects of 4-hydroxyamphetamine on in vivo brown adipose tissue thermogenesis and feeding behavior in the rat.

    abstract::The influence of 4-hydroxyamphetamine (4-OHAM) on food and water intake and in vivo brown adipose thermogenesis was examined in two experiments. In Experiment 1, female rats were treated with 0.00, 0.25, 0.50, 1.00, or 2.00 mg/kg 4-OHAM (ip) prior to assessment of interscapular brown adipose tissue (IBAT) thermogenesi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.6.1060

    authors: Wellman PJ,Watkins-Freeman PA

    更新日期:1984-12-01 00:00:00

  • Neuroethological studies of reflex plasticity in intact Aplysia.

    abstract::Multi-unit recording of siphon nerve activity in intact Aplysia california with chronically implanted cuff electrodes provided a monitor of activity in a central pattern generator, the Interneuron II (Int II) network, which produces large siphon and gill contractions both spontaneously and after tactile stimulation of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.4.609

    authors: Eberly LB,Pinsker HM

    更新日期:1984-08-01 00:00:00

  • Behavior of rat fetuses following chemical or tactile stimulation.

    abstract::The behavior of fetal rats was examined on Day 19 of gestation with procedures that enabled chemical stimulation and direct observation of fetuses. Rat fetuses are sensitive to both tactile stroking and intraoral infusion of chemical solutions, but the pattern and amount of activity depend upon the modality of stimula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.1.24

    authors: Smotherman WP,Robinson SR

    更新日期:1988-02-01 00:00:00

  • Drug discrimination training during chronic drug treatment affects the development of tolerance.

    abstract::The purpose of this experiment was to evaluate the extent to which continued drug discrimination training during chronic drug treatment affects the development of tolerance. Rats were trained to discriminate distilled water from 0.75 mg/kg amphetamine in a two-lever drug discrimination task. Two groups were then given...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.2.373

    authors: Caul WF,Burgin KL,Barrett RJ

    更新日期:1989-04-01 00:00:00

  • Bilateral nature of the conditioned eyeblink response in the rabbit: behavioral characteristics and potential mechanisms.

    abstract::In Pavlovian eyeblink conditioning, the conditioned response (CR) is highly lateralized to the eye to which the unconditioned stimulus (US) has been directed. However, the initial conditioning of one eye can facilitate subsequent conditioning of the other eye, a phenomenon known as the intereye transfer (IET) effect. ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0013591

    authors: Lee T,Kim JJ,Wagner AR

    更新日期:2008-12-01 00:00:00

  • Preferential use of the landmark navigational system by head direction cells in rats.

    abstract::Previous studies have identified a population of cells recorded in the postsubiculum and the anterior thalamic nucleus (ATN) that discharge as a function of an animal's head direction (HD) in the horizontal plane. The present experiments monitored HD cell activity when rats were confronted with a situation in which di...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.1.49

    authors: Goodridge JP,Taube JS

    更新日期:1995-02-01 00:00:00