Behavioral effects of methylazoxymethanol-induced micrencephaly.

Abstract:

:This study was prompted by reports of functionally normal humans with micrencephaly or cortical hypoplasia. Methylazoxymethanol acetate (MAM) treatment, which induces micrencephaly in rats, was administered by injection (20 mg/kg) on gestational day 14. Prior to weaning and into adulthood, offspring were assessed on many behavioral tests. There were 3 findings. First, MAM rats (forebrain weight less than 2/3 of controls) were not profoundly hyperactive. Increased activity was seen only on prolonged tests or after amphetamine administration. Second, MAM rats were hypoactive in some conditions. These rats were light shy and less likely to explore lighted areas. MAM rats appeared hyperreactive to environmental stimuli, but not hyperactive. Finally, no MAM effect on behavior was as large as that on brain weight. Thus, as with clinical findings, rat micrencephalics are more remarkable for functional sparing than for behavioral abnormalities.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Ferguson SA,Racey FD,Paule MG,Holson RR

doi

10.1037//0735-7044.107.6.1067

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

1067-76

issue

6

eissn

0735-7044

issn

1939-0084

journal_volume

107

pub_type

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