Abstract:
:Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to nociception. The induction of a spinally mediated antinociception was accompanied by an increase in latency to vocalize to a noxious thermal stimulus, suggesting pain inhibition. Physiological manipulations that eliminated the inhibition of the tail-flick reflex restored vocalization to thermal stimulation and revealed a concurrent sensitization that generally heightened behavioral reactivity. The results suggest that net pain is regulated by 2 opposing processes, a selective inhibition of nociceptive signals within the spinal cord and a general sensitization that heightens stimulus processing.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Crown ED,Grau JW,Meagher MWdoi
10.1037/0735-7044.118.6.1418subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1418-26issue
6eissn
0735-7044issn
1939-0084pii
2004-21410-028journal_volume
118pub_type
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