Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity.

Abstract:

:Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to nociception. The induction of a spinally mediated antinociception was accompanied by an increase in latency to vocalize to a noxious thermal stimulus, suggesting pain inhibition. Physiological manipulations that eliminated the inhibition of the tail-flick reflex restored vocalization to thermal stimulation and revealed a concurrent sensitization that generally heightened behavioral reactivity. The results suggest that net pain is regulated by 2 opposing processes, a selective inhibition of nociceptive signals within the spinal cord and a general sensitization that heightens stimulus processing.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Crown ED,Grau JW,Meagher MW

doi

10.1037/0735-7044.118.6.1418

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1418-26

issue

6

eissn

0735-7044

issn

1939-0084

pii

2004-21410-028

journal_volume

118

pub_type

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