Abstract:
:The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with the TaqI A1 allele. Energy intake was greater for individuals high in food reinforcement and greatest in those high in food reinforcement with the TaqI A1 allele. No effect of the DAT1 genotype was observed. These data show that individual differences in food reinforcement may be important for obesity and that the DRD2 genotype may interact with food reinforcement to influence energy intake.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Epstein LH,Temple JL,Neaderhiser BJ,Salis RJ,Erbe RW,Leddy JJdoi
10.1037/0735-7044.121.5.877subject
Has Abstractpub_date
2007-10-01 00:00:00pages
877-86issue
5eissn
0735-7044issn
1939-0084pii
2007-13974-007journal_volume
121pub_type
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