Abstract:
:The shy-bold continuum is a fundamental behavioral trait conserved across human and nonhuman animals. Individual differences along the shy-bold continuum are presumed to arise from, and are maintained by, differences in the excitability of forebrain limbic areas involved in the evaluation of stimulus saliency. To test this hypothesis, the authors conducted an event-related functional MRI (fMRI) study in which brain scans were acquired on shy and bold adults during the presentation of neutral stranger and personally familiar faces. Shy adults exhibited greater bilateral amygdala activation during the presentation of stranger faces and greater left amygdala activation during personally familiar faces than their bold counterparts. Bold adults exhibited greater bilateral nucleus accumbens activation in response to stranger and personally familiar faces than shy adults. Findings suggest that there are distinct neural substrates underlying and maintaining individual differences along a shy-bold continuum in humans.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Beaton EA,Schmidt LA,Schulkin J,Antony MM,Swinson RP,Hall GBdoi
10.1037/0735-7044.122.3.704subject
Has Abstractpub_date
2008-06-01 00:00:00pages
704-9issue
3eissn
0735-7044issn
1939-0084pii
2008-06403-022journal_volume
122pub_type
杂志文章abstract::To determine whether dopamine signaling in the dorsal striatum is sufficient for performance of goal-directed behaviors, local dopamine production was restored in the dorsal striatum of dopamine-deficient (DD) mice through viral-mediated gene therapy. Virally rescued DD (vrDD) mice were tested for learning of an appet...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.120.1.000
更新日期:2006-02-01 00:00:00
abstract::The acoustic startle response (ASR) of male rats was measured during several sessions over a 24-hr period in both a light-dark cycle and a constant-dark condition. Each session consisted of 10 trials each at 80, 90, 100, 110, and 120 dB white noise. The results indicate robust daily and circadian modulation of ASR amp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.5.846
更新日期:1992-10-01 00:00:00
abstract::Young and aged animals were tested on a spatial alternation task that consisted of two interleaved components: (1) an "outbound" or alternation component (working memory) and (2) an "inbound" component, requiring the animal to remember to return to a central location in space (spatial memory). In the present study, ag...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000269
更新日期:2018-12-01 00:00:00
abstract::The effects of peripherally administered leucine-enkephalin on the acquisition and retention of active avoidance behavior was studied in mice. Mice received 4 training trials on Day 1, 24 test trials on Day 2, and 10 test trials on Day 5. Leucine-enkephalin impaired the aquisition of avoidance behavior when administer...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.100.2.185
更新日期:1986-04-01 00:00:00
abstract::Available evidence indicates that common genes influence alcohol and tobacco abuse in humans. The studies reported here used mouse models to evaluate the hypothesis that genetically determined variability in the alpha4beta2* nicotinic receptor modulates genetically determined variability in the intake of both nicotine...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.1.26
更新日期:2005-02-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is caused by lack of paternally derived gene expression from the imprinted gene cluster on human chromosome 15q11-q13. PWS is characterized by severe hypotonia, a failure to thrive in infancy and, on emerging from infancy, evidence of learning disabilities and overeating behavior due to an ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0028155
更新日期:2012-06-01 00:00:00
abstract::An influential view in the field of spatial cognition is that an obligatory geometric module constrains spatial learning and memory. In this issue, P. M. Jones, J. M. Pearce, V. J. Davies, M. A. Good, and A. McGregor (2007) showed that learning based on the geometry, or shape, of the environment requires the hippocamp...
journal_title:Behavioral neuroscience
pub_type: 评论,杂志文章
doi:10.1037/0735-7044.121.6.1442
更新日期:2007-12-01 00:00:00
abstract::Repeated administration of apomorphine leads to a context-dependent pecking response sensitization. Previously sensitized pigeons (Columba livia) challenged with saline in the same context show a conditioned response (CR). The authors studied the effects of intrastriatal injections of the dopamine (D(1)) antagonist SC...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.5.1080
更新日期:2004-10-01 00:00:00
abstract::Rhesus monkeys were trained to learn a large series of visuomotor conditional associations, each involving the arbitrary coupling of a visual stimulus with 1 of 3 potentially correct forelimb movements. The monkeys then received bilateral aspiration lesions of either the amygdala plus subjacent cortex or the hippocamp...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.6.1261
更新日期:1996-12-01 00:00:00
abstract::Benzodiazepines are known to reduce learning and memory performance, presumably through their facilitation of GABAergic neurotransmission, but the effects of these drugs specifically on memory for emotional material has not been addressed in humans. The effects of a benzodiazepine (triazolam, 0.25 mg) on nonincidental...
journal_title:Behavioral neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1037/0735-7044.117.3.517
更新日期:2003-06-01 00:00:00
abstract::The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.3.504
更新日期:1989-06-01 00:00:00
abstract::A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, altho...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0026180
更新日期:2011-12-01 00:00:00
abstract::Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993). The results presented here provide evidence in humans supporting these hypo...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.1.223
更新日期:2004-02-01 00:00:00
abstract::In infant rats, administration of the alpha2 adrenoceptor agonist clonidine simultaneously evokes ultrasound production and bradycardia. In this study the authors examined in 8-day-old rats whether these 2 responses to clonidine are causally related. In Experiment 1 pups were pretreated with saline or prenalterol (0.1...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::The role of the thalamus in memory is potentially very complex. However, most studies on the memory impairments of thalamic lesions have focused on retrospective memory, rarely on prospective memory. To explore the effect of thalamic lesions on event-based prospective memory (EBPM) and time-based prospective memory (T...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0018306
更新日期:2010-02-01 00:00:00
abstract::This study determined the effects of estrogen loss and replacement therapy on learning and memory function in monkeys (Macaca fascicularis). The ability to learn, remember, and perform reversals of object discriminations and the accuracy on a spatial delayed response task were found to be comparable in young adult sur...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract::In sighted humans, light intensity, timing, exposure duration, and spectral composition of light are important to entrain the endogenous circadian pacemaker to the 24-h day-night cycle. We tested the impact of two realistic office lighting conditions during the afternoon on subjective sleepiness, hormonal secretion, a...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0026702
更新日期:2012-02-01 00:00:00
abstract::The influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and perforant path LTP were assessed in pentobarbital-anesthetized rats. Water deprivation did not affect baseline cell excitabi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.108.1.44
更新日期:1994-02-01 00:00:00
abstract::In the cognitive mapping theory of hippocampal function, currently active place cells represent a rat's spatial location (J. O'Keefe & L. Nadel, 1978). A systematic shift of firing field locations should therefore produce a similar shift in a rat's judgment of its location. A. A. Fenton, G. Csizmadia, and R. U. Muller...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.121.4.751
更新日期:2007-08-01 00:00:00
abstract::The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disorders and schizophrenia. However, the link between α-neurexin deficien...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000108
更新日期:2015-12-01 00:00:00
abstract::Rats were injected with naloxone hydrochloride (3 mg/kg) or saline and subjected to preshock or no preshock prior to receiving a test shock that elicited defensive burying. Preshock was administered in a context different from, or the same as, that in which the test shock was delivered. The combination of naloxone and...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.99.3.436
更新日期:1985-06-01 00:00:00
abstract::Cognitive functions, such as working memory, are disrupted in most psychiatric disorders. Many of these processes are believed to depend on the medial prefrontal cortex (mPFC). Traditionally, maze-based behavioral tasks, which have a strong exploratory component, have been used to study the role of the mPFC in working...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000357
更新日期:2020-06-01 00:00:00
abstract::Fetal and maternal data were monitored serially at 6 gestational ages from 20 to 38 weeks in 195 Peruvian fetuses. Digitized data included fetal heart rate and motor activity, as well as maternal heart rate and electrodermal conductance. Time series analysis evaluated the development of synchrony in 2 streams of fetal...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.120.3.687
更新日期:2006-06-01 00:00:00
abstract::Dopaminergic blocking agents have been known to suppress intracranial self-stimulation, but whether the suppression results from a reduction in the rewarding value of stimulation or from motor deficits has remained controversial. We have resolved this controversy by developing an operant technique minimally dependent ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.101.5.626
更新日期:1987-10-01 00:00:00
abstract::Lesion studies have shown that the avian hippocampus plays a crucial role in homing pigeon (Columba livia) navigation. Using the expression of the immediate early gene protein ZENK in intact pigeons, the authors found regional variation in hippocampal activation as a consequence of homing and, necessarily, the behavio...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.118.4.845
更新日期:2004-08-01 00:00:00
abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000134
更新日期:2016-04-01 00:00:00
abstract::The kinematic parameters of air-stepping induced by 2 methods known to elicit locomotion (olfactory stimulation vs. L-dopa injection) were compared in 3-day-old rats. In the 1st stage, suspended pups were induced to step with an olfactory stimulus of soiled shavings from the nest. In the 2nd stage, they received a sub...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.116.6.1014
更新日期:2002-12-01 00:00:00
abstract::Sustained potential shifts (SPS) were recorded for 10 s from the surface of the optic tectum of toads presented with live prey and moving artificial prey stimuli. On the anterior tectal surface, a negative SPS was followed by a positive wave; the converse was true for the posterior tectum. Some animals were immobilize...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.109.1.150
更新日期:1995-02-01 00:00:00
abstract::In contrast to humans, sodium-replete rats prefer dilute saline to water and do not prefer salted food to plain food. Sodium depletion is known to enhance the intake of and preference for salt provided in water. Here, we examined whether the context of the delivery vehicle for salt could influence salt intake and pref...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.4.565
更新日期:1988-08-01 00:00:00
abstract::Although mnemonic interpretations of hippocampal function in people have been readily accepted for many years, similar interpretations of hippocampal function in animals have received a number of challenges. This article reviews two of these challenges, shows how they were resolved in favor of some kind of mnemonic in...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.1037//0735-7044.100.6.852
更新日期:1986-12-01 00:00:00