Air-stepping in neonatal rats: A comparison of L-dopa injection and olfactory stimulation.

Abstract:

:The kinematic parameters of air-stepping induced by 2 methods known to elicit locomotion (olfactory stimulation vs. L-dopa injection) were compared in 3-day-old rats. In the 1st stage, suspended pups were induced to step with an olfactory stimulus of soiled shavings from the nest. In the 2nd stage, they received a subcutaneous injection of L-dopa. Their movements were faster, with a larger amplitude and a phase delay in ipsilateral coupling. Third, the olfactory stimulus was presented in conjunction with L-dopa. The characteristics of locomotion returned to the same level as with the olfactory stimulus alone. These results suggest that olfactory stimulation involves higher nerve centers able to modulate the dopaminergic pathways. They are discussed in relation to the neural structure involved in locomotion.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Jamon M,Maloum I,Riviere G,Bruguerolle B

doi

10.1037//0735-7044.116.6.1014

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1014-21

issue

6

eissn

0735-7044

issn

1939-0084

journal_volume

116

pub_type

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